diff --git a/Source/Core/Common/StringUtil.cpp b/Source/Core/Common/StringUtil.cpp
index a752ab0e10..c498e261fd 100644
--- a/Source/Core/Common/StringUtil.cpp
+++ b/Source/Core/Common/StringUtil.cpp
@@ -335,6 +335,23 @@ bool SplitPath(std::string_view full_path, std::string* path, std::string* filen
   return true;
 }
 
+void UnifyPathSeparators(std::string& path)
+{
+#ifdef _WIN32
+  for (char& c : path)
+  {
+    if (c == '\\')
+      c = '/';
+  }
+#endif
+}
+
+std::string WithUnifiedPathSeparators(std::string path)
+{
+  UnifyPathSeparators(path);
+  return path;
+}
+
 std::string PathToFileName(std::string_view path)
 {
   std::string file_name, extension;
diff --git a/Source/Core/Common/StringUtil.h b/Source/Core/Common/StringUtil.h
index 56fa756a46..5db7cbfa37 100644
--- a/Source/Core/Common/StringUtil.h
+++ b/Source/Core/Common/StringUtil.h
@@ -157,9 +157,17 @@ std::vector<std::string> SplitString(const std::string& str, char delim);
 std::string JoinStrings(const std::vector<std::string>& strings, const std::string& delimiter);
 
 // "C:/Windows/winhelp.exe" to "C:/Windows/", "winhelp", ".exe"
+// This requires forward slashes to be used for the path separators, even on Windows.
 bool SplitPath(std::string_view full_path, std::string* path, std::string* filename,
                std::string* extension);
 
+// Converts the path separators of a path into forward slashes on Windows, which is assumed to be
+// true for paths at various places in the codebase.
+void UnifyPathSeparators(std::string& path);
+std::string WithUnifiedPathSeparators(std::string path);
+
+// Extracts just the filename (including extension) from a full path.
+// This requires forward slashes to be used for the path separators, even on Windows.
 std::string PathToFileName(std::string_view path);
 
 bool StringBeginsWith(std::string_view str, std::string_view begin);
diff --git a/Source/Core/Core/Boot/Boot.cpp b/Source/Core/Core/Boot/Boot.cpp
index 0ad7f6ec12..4e2844c95b 100644
--- a/Source/Core/Core/Boot/Boot.cpp
+++ b/Source/Core/Core/Boot/Boot.cpp
@@ -311,8 +311,8 @@ std::unique_ptr<BootParameters> BootParameters::GenerateFromFile(std::vector<std
 
 BootParameters::IPL::IPL(DiscIO::Region region_) : region(region_)
 {
-  const std::string directory = SConfig::GetInstance().GetDirectoryForRegion(region);
-  path = SConfig::GetInstance().GetBootROMPath(directory);
+  const std::string directory = Config::GetDirectoryForRegion(region);
+  path = Config::GetBootROMPath(directory);
 }
 
 BootParameters::IPL::IPL(DiscIO::Region region_, Disc&& disc_) : IPL(region_)
@@ -434,7 +434,7 @@ bool CBoot::Load_BS2(const std::string& boot_rom_filename)
   if (known_ipl && pal_ipl != (boot_region == DiscIO::Region::PAL))
   {
     PanicAlertFmtT("{0} IPL found in {1} directory. The disc might not be recognized",
-                   pal_ipl ? "PAL" : "NTSC", SConfig::GetDirectoryForRegion(boot_region));
+                   pal_ipl ? "PAL" : "NTSC", Config::GetDirectoryForRegion(boot_region));
   }
 
   // Run the descrambler over the encrypted section containing BS1/BS2
diff --git a/Source/Core/Core/Config/MainSettings.cpp b/Source/Core/Core/Config/MainSettings.cpp
index 42d1e9fe18..d7d146e3e2 100644
--- a/Source/Core/Core/Config/MainSettings.cpp
+++ b/Source/Core/Core/Config/MainSettings.cpp
@@ -12,6 +12,7 @@
 #include "Common/CommonPaths.h"
 #include "Common/Config/Config.h"
 #include "Common/EnumMap.h"
+#include "Common/FileUtil.h"
 #include "Common/Logging/Log.h"
 #include "Common/MathUtil.h"
 #include "Common/StringUtil.h"
@@ -19,6 +20,7 @@
 #include "Core/Config/DefaultLocale.h"
 #include "Core/HW/EXI/EXI.h"
 #include "Core/HW/EXI/EXI_Device.h"
+#include "Core/HW/GCMemcard/GCMemcard.h"
 #include "Core/HW/HSP/HSP_Device.h"
 #include "Core/HW/Memmap.h"
 #include "Core/HW/SI/SI_Device.h"
@@ -523,4 +525,97 @@ void SetUSBDeviceWhitelist(const std::set<std::pair<u16, u16>>& devices)
 {
   Config::SetBase(Config::MAIN_USB_PASSTHROUGH_DEVICES, SaveUSBWhitelistToString(devices));
 }
+
+// The reason we need this function is because some memory card code
+// expects to get a non-NTSC-K region even if we're emulating an NTSC-K Wii.
+DiscIO::Region ToGameCubeRegion(DiscIO::Region region)
+{
+  if (region != DiscIO::Region::NTSC_K)
+    return region;
+
+  // GameCube has no NTSC-K region. No choice of replacement value is completely
+  // non-arbitrary, but let's go with NTSC-J since Korean GameCubes are NTSC-J.
+  return DiscIO::Region::NTSC_J;
+}
+
+const char* GetDirectoryForRegion(DiscIO::Region region)
+{
+  if (region == DiscIO::Region::Unknown)
+    region = ToGameCubeRegion(Config::Get(Config::MAIN_FALLBACK_REGION));
+
+  switch (region)
+  {
+  case DiscIO::Region::NTSC_J:
+    return JAP_DIR;
+
+  case DiscIO::Region::NTSC_U:
+    return USA_DIR;
+
+  case DiscIO::Region::PAL:
+    return EUR_DIR;
+
+  case DiscIO::Region::NTSC_K:
+    ASSERT_MSG(BOOT, false, "NTSC-K is not a valid GameCube region");
+    return JAP_DIR;  // See ToGameCubeRegion
+
+  default:
+    ASSERT_MSG(BOOT, false, "Default case should not be reached");
+    return EUR_DIR;
+  }
+}
+
+std::string GetBootROMPath(const std::string& region_directory)
+{
+  const std::string path =
+      File::GetUserPath(D_GCUSER_IDX) + DIR_SEP + region_directory + DIR_SEP GC_IPL;
+  if (!File::Exists(path))
+    return File::GetSysDirectory() + GC_SYS_DIR + DIR_SEP + region_directory + DIR_SEP GC_IPL;
+  return path;
+}
+
+std::string GetMemcardPath(ExpansionInterface::Slot slot, DiscIO::Region region, u16 size_mb)
+{
+  return GetMemcardPath(Config::Get(GetInfoForMemcardPath(slot)), slot, region, size_mb);
+}
+
+std::string GetMemcardPath(std::string configured_filename, ExpansionInterface::Slot slot,
+                           DiscIO::Region region, u16 size_mb)
+{
+  const std::string region_dir = Config::GetDirectoryForRegion(Config::ToGameCubeRegion(region));
+  const std::string blocks_string = size_mb < Memcard::MBIT_SIZE_MEMORY_CARD_2043 ?
+                                        fmt::format(".{}", Memcard::MbitToFreeBlocks(size_mb)) :
+                                        "";
+
+  if (configured_filename.empty())
+  {
+    // Use default memcard path if there is no user defined one.
+    const bool is_slot_a = slot == ExpansionInterface::Slot::A;
+    return fmt::format("{}{}.{}{}.raw", File::GetUserPath(D_GCUSER_IDX),
+                       is_slot_a ? GC_MEMCARDA : GC_MEMCARDB, region_dir, blocks_string);
+  }
+
+  // Custom path is expected to be stored in the form of
+  // "/path/to/file.{region_code}.raw"
+  // with an arbitrary but supported region code.
+  // Try to extract and replace that region code.
+  // If there's no region code just insert one before the extension.
+
+  std::string dir;
+  std::string name;
+  std::string ext;
+  UnifyPathSeparators(configured_filename);
+  SplitPath(configured_filename, &dir, &name, &ext);
+
+  constexpr std::string_view us_region = "." USA_DIR;
+  constexpr std::string_view jp_region = "." JAP_DIR;
+  constexpr std::string_view eu_region = "." EUR_DIR;
+  if (StringEndsWith(name, us_region))
+    name = name.substr(0, name.size() - us_region.size());
+  else if (StringEndsWith(name, jp_region))
+    name = name.substr(0, name.size() - jp_region.size());
+  else if (StringEndsWith(name, eu_region))
+    name = name.substr(0, name.size() - eu_region.size());
+
+  return fmt::format("{}{}.{}{}{}", dir, name, region_dir, blocks_string, ext);
+}
 }  // namespace Config
diff --git a/Source/Core/Core/Config/MainSettings.h b/Source/Core/Core/Config/MainSettings.h
index 4ed43a79da..e1b538f2b6 100644
--- a/Source/Core/Core/Config/MainSettings.h
+++ b/Source/Core/Core/Config/MainSettings.h
@@ -331,4 +331,15 @@ extern const Info<std::string> MAIN_USB_PASSTHROUGH_DEVICES;
 std::set<std::pair<u16, u16>> GetUSBDeviceWhitelist();
 void SetUSBDeviceWhitelist(const std::set<std::pair<u16, u16>>& devices);
 
+// GameCube path utility functions
+
+// Replaces NTSC-K with some other region, and doesn't replace non-NTSC-K regions
+DiscIO::Region ToGameCubeRegion(DiscIO::Region region);
+// The region argument must be valid for GameCube (i.e. must not be NTSC-K)
+const char* GetDirectoryForRegion(DiscIO::Region region);
+std::string GetBootROMPath(const std::string& region_directory);
+std::string GetMemcardPath(ExpansionInterface::Slot slot, DiscIO::Region region,
+                           u16 size_mb = 0x80);
+std::string GetMemcardPath(std::string configured_filename, ExpansionInterface::Slot slot,
+                           DiscIO::Region region, u16 size_mb = 0x80);
 }  // namespace Config
diff --git a/Source/Core/Core/ConfigManager.cpp b/Source/Core/Core/ConfigManager.cpp
index 2d90207601..497d938f76 100644
--- a/Source/Core/Core/ConfigManager.cpp
+++ b/Source/Core/Core/ConfigManager.cpp
@@ -220,53 +220,6 @@ std::string SConfig::MakeGameID(std::string_view file_name)
   return "ID-" + std::string(file_name.substr(0, lastdot));
 }
 
-// The reason we need this function is because some memory card code
-// expects to get a non-NTSC-K region even if we're emulating an NTSC-K Wii.
-DiscIO::Region SConfig::ToGameCubeRegion(DiscIO::Region region)
-{
-  if (region != DiscIO::Region::NTSC_K)
-    return region;
-
-  // GameCube has no NTSC-K region. No choice of replacement value is completely
-  // non-arbitrary, but let's go with NTSC-J since Korean GameCubes are NTSC-J.
-  return DiscIO::Region::NTSC_J;
-}
-
-const char* SConfig::GetDirectoryForRegion(DiscIO::Region region)
-{
-  if (region == DiscIO::Region::Unknown)
-    region = ToGameCubeRegion(GetFallbackRegion());
-
-  switch (region)
-  {
-  case DiscIO::Region::NTSC_J:
-    return JAP_DIR;
-
-  case DiscIO::Region::NTSC_U:
-    return USA_DIR;
-
-  case DiscIO::Region::PAL:
-    return EUR_DIR;
-
-  case DiscIO::Region::NTSC_K:
-    ASSERT_MSG(BOOT, false, "NTSC-K is not a valid GameCube region");
-    return JAP_DIR;  // See ToGameCubeRegion
-
-  default:
-    ASSERT_MSG(BOOT, false, "Default case should not be reached");
-    return EUR_DIR;
-  }
-}
-
-std::string SConfig::GetBootROMPath(const std::string& region_directory) const
-{
-  const std::string path =
-      File::GetUserPath(D_GCUSER_IDX) + DIR_SEP + region_directory + DIR_SEP GC_IPL;
-  if (!File::Exists(path))
-    return File::GetSysDirectory() + GC_SYS_DIR + DIR_SEP + region_directory + DIR_SEP GC_IPL;
-  return path;
-}
-
 struct SetGameMetadata
 {
   SetGameMetadata(SConfig* config_, DiscIO::Region* region_) : config(config_), region(region_) {}
@@ -375,21 +328,16 @@ bool SConfig::SetPathsAndGameMetadata(const BootParameters& boot)
     return false;
 
   if (m_region == DiscIO::Region::Unknown)
-    m_region = GetFallbackRegion();
+    m_region = Config::Get(Config::MAIN_FALLBACK_REGION);
 
   // Set up paths
-  const std::string region_dir = GetDirectoryForRegion(ToGameCubeRegion(m_region));
+  const std::string region_dir = Config::GetDirectoryForRegion(Config::ToGameCubeRegion(m_region));
   m_strSRAM = File::GetUserPath(F_GCSRAM_IDX);
-  m_strBootROM = GetBootROMPath(region_dir);
+  m_strBootROM = Config::GetBootROMPath(region_dir);
 
   return true;
 }
 
-DiscIO::Region SConfig::GetFallbackRegion()
-{
-  return Config::Get(Config::MAIN_FALLBACK_REGION);
-}
-
 DiscIO::Language SConfig::GetCurrentLanguage(bool wii) const
 {
   DiscIO::Language language;
diff --git a/Source/Core/Core/ConfigManager.h b/Source/Core/Core/ConfigManager.h
index bb0b165249..6a6045c0f8 100644
--- a/Source/Core/Core/ConfigManager.h
+++ b/Source/Core/Core/ConfigManager.h
@@ -72,13 +72,7 @@ struct SConfig
 
   void LoadDefaults();
   static std::string MakeGameID(std::string_view file_name);
-  // Replaces NTSC-K with some other region, and doesn't replace non-NTSC-K regions
-  static DiscIO::Region ToGameCubeRegion(DiscIO::Region region);
-  // The region argument must be valid for GameCube (i.e. must not be NTSC-K)
-  static const char* GetDirectoryForRegion(DiscIO::Region region);
-  std::string GetBootROMPath(const std::string& region_directory) const;
   bool SetPathsAndGameMetadata(const BootParameters& boot);
-  static DiscIO::Region GetFallbackRegion();
   DiscIO::Language GetCurrentLanguage(bool wii) const;
   DiscIO::Language GetLanguageAdjustedForRegion(bool wii, DiscIO::Region region) const;
 
diff --git a/Source/Core/Core/HW/EXI/EXI.cpp b/Source/Core/Core/HW/EXI/EXI.cpp
index eb1d99e81e..c480e09235 100644
--- a/Source/Core/Core/HW/EXI/EXI.cpp
+++ b/Source/Core/Core/HW/EXI/EXI.cpp
@@ -117,7 +117,7 @@ void Init()
     if (size_override >= 0 && size_override <= 4)
       size_mbits = Memcard::MBIT_SIZE_MEMORY_CARD_59 << size_override;
     const bool shift_jis =
-        SConfig::ToGameCubeRegion(SConfig::GetInstance().m_region) == DiscIO::Region::NTSC_J;
+        Config::ToGameCubeRegion(SConfig::GetInstance().m_region) == DiscIO::Region::NTSC_J;
     const CardFlashId& flash_id = g_SRAM.settings_ex.flash_id[Memcard::SLOT_A];
     const u32 rtc_bias = g_SRAM.settings.rtc_bias;
     const u32 sram_language = static_cast<u32>(g_SRAM.settings.language);
diff --git a/Source/Core/Core/HW/EXI/EXI_DeviceMemoryCard.cpp b/Source/Core/Core/HW/EXI/EXI_DeviceMemoryCard.cpp
index c7538ceae2..83263ed04d 100644
--- a/Source/Core/Core/HW/EXI/EXI_DeviceMemoryCard.cpp
+++ b/Source/Core/Core/HW/EXI/EXI_DeviceMemoryCard.cpp
@@ -162,8 +162,8 @@ CEXIMemoryCard::GetGCIFolderPath(Slot card_slot, AllowMovieFolder allow_movie_fo
   if (use_movie_folder)
     path += "Movie" DIR_SEP;
 
-  const DiscIO::Region region = SConfig::ToGameCubeRegion(SConfig::GetInstance().m_region);
-  path = path + SConfig::GetDirectoryForRegion(region) + DIR_SEP +
+  const DiscIO::Region region = Config::ToGameCubeRegion(SConfig::GetInstance().m_region);
+  path = path + Config::GetDirectoryForRegion(region) + DIR_SEP +
          fmt::format("Card {}", s_card_short_names[card_slot]);
   return {std::move(path), !use_movie_folder};
 }
@@ -188,7 +188,7 @@ void CEXIMemoryCard::SetupGciFolder(const Memcard::HeaderData& header_data)
   if (!file_info.Exists())
   {
     if (migrate)  // first use of memcard folder, migrate automatically
-      MigrateFromMemcardFile(dir_path + DIR_SEP, m_card_slot);
+      MigrateFromMemcardFile(dir_path + DIR_SEP, m_card_slot, SConfig::GetInstance().m_region);
     else
       File::CreateFullPath(dir_path + DIR_SEP);
   }
@@ -198,7 +198,7 @@ void CEXIMemoryCard::SetupGciFolder(const Memcard::HeaderData& header_data)
     {
       PanicAlertFmtT("{0} was not a directory, moved to *.original", dir_path);
       if (migrate)
-        MigrateFromMemcardFile(dir_path + DIR_SEP, m_card_slot);
+        MigrateFromMemcardFile(dir_path + DIR_SEP, m_card_slot, SConfig::GetInstance().m_region);
       else
         File::CreateFullPath(dir_path + DIR_SEP);
     }
@@ -218,22 +218,16 @@ void CEXIMemoryCard::SetupGciFolder(const Memcard::HeaderData& header_data)
 
 void CEXIMemoryCard::SetupRawMemcard(u16 size_mb)
 {
-  std::string filename = Config::Get(Config::GetInfoForMemcardPath(m_card_slot));
+  std::string filename;
   if (Movie::IsPlayingInput() && Movie::IsConfigSaved() && Movie::IsUsingMemcard(m_card_slot) &&
       Movie::IsStartingFromClearSave())
   {
     filename = File::GetUserPath(D_GCUSER_IDX) +
                fmt::format("Movie{}.raw", s_card_short_names[m_card_slot]);
   }
-
-  const std::string region_dir =
-      SConfig::GetDirectoryForRegion(SConfig::ToGameCubeRegion(SConfig::GetInstance().m_region));
-  MemoryCard::CheckPath(filename, region_dir, m_card_slot);
-
-  if (size_mb < Memcard::MBIT_SIZE_MEMORY_CARD_2043)
+  else
   {
-    filename.insert(filename.find_last_of('.'),
-                    fmt::format(".{}", Memcard::MbitToFreeBlocks(size_mb)));
+    filename = Config::GetMemcardPath(m_card_slot, SConfig::GetInstance().m_region, size_mb);
   }
 
   m_memory_card = std::make_unique<MemoryCard>(filename, m_card_slot, size_mb);
diff --git a/Source/Core/Core/HW/GCMemcard/GCMemcardDirectory.cpp b/Source/Core/Core/HW/GCMemcard/GCMemcardDirectory.cpp
index b65d7f0d03..f5a46046c0 100644
--- a/Source/Core/Core/HW/GCMemcard/GCMemcardDirectory.cpp
+++ b/Source/Core/Core/HW/GCMemcard/GCMemcardDirectory.cpp
@@ -705,10 +705,11 @@ void GCMemcardDirectory::DoState(PointerWrap& p)
   }
 }
 
-void MigrateFromMemcardFile(const std::string& directory_name, ExpansionInterface::Slot card_slot)
+void MigrateFromMemcardFile(const std::string& directory_name, ExpansionInterface::Slot card_slot,
+                            DiscIO::Region region)
 {
   File::CreateFullPath(directory_name);
-  std::string ini_memcard = Config::Get(Config::GetInfoForMemcardPath(card_slot));
+  const std::string ini_memcard = Config::GetMemcardPath(card_slot, region);
   if (File::Exists(ini_memcard))
   {
     auto [error_code, memcard] = Memcard::GCMemcard::Open(ini_memcard.c_str());
diff --git a/Source/Core/Core/HW/GCMemcard/GCMemcardDirectory.h b/Source/Core/Core/HW/GCMemcard/GCMemcardDirectory.h
index fa9ae44110..5b02700a61 100644
--- a/Source/Core/Core/HW/GCMemcard/GCMemcardDirectory.h
+++ b/Source/Core/Core/HW/GCMemcard/GCMemcardDirectory.h
@@ -12,10 +12,12 @@
 #include "Core/HW/GCMemcard/GCIFile.h"
 #include "Core/HW/GCMemcard/GCMemcard.h"
 #include "Core/HW/GCMemcard/GCMemcardBase.h"
+#include "DiscIO/Enums.h"
 
 // Uncomment this to write the system data of the memorycard from directory to disc
 //#define _WRITE_MC_HEADER 1
-void MigrateFromMemcardFile(const std::string& directory_name, ExpansionInterface::Slot card_slot);
+void MigrateFromMemcardFile(const std::string& directory_name, ExpansionInterface::Slot card_slot,
+                            DiscIO::Region region);
 
 class GCMemcardDirectory : public MemoryCardBase
 {
diff --git a/Source/Core/Core/HW/GCMemcard/GCMemcardRaw.cpp b/Source/Core/Core/HW/GCMemcard/GCMemcardRaw.cpp
index 923f88bc69..23bca41df1 100644
--- a/Source/Core/Core/HW/GCMemcard/GCMemcardRaw.cpp
+++ b/Source/Core/Core/HW/GCMemcard/GCMemcardRaw.cpp
@@ -90,55 +90,6 @@ MemoryCard::~MemoryCard()
   }
 }
 
-void MemoryCard::CheckPath(std::string& memcardPath, const std::string& gameRegion,
-                           ExpansionInterface::Slot card_slot)
-{
-  bool is_slot_a = card_slot == ExpansionInterface::Slot::A;
-  std::string ext("." + gameRegion + ".raw");
-  if (memcardPath.empty())
-  {
-    // Use default memcard path if there is no user defined name
-    std::string defaultFilename = is_slot_a ? GC_MEMCARDA : GC_MEMCARDB;
-    memcardPath = File::GetUserPath(D_GCUSER_IDX) + defaultFilename + ext;
-  }
-  else
-  {
-    std::string filename = memcardPath;
-    std::string region = filename.substr(filename.size() - 7, 3);
-    bool hasregion = false;
-    hasregion |= region.compare(USA_DIR) == 0;
-    hasregion |= region.compare(JAP_DIR) == 0;
-    hasregion |= region.compare(EUR_DIR) == 0;
-    if (!hasregion)
-    {
-      // filename doesn't have region in the extension
-      if (File::Exists(filename))
-      {
-        // If the old file exists we are polite and ask if we should copy it
-        std::string oldFilename = filename;
-        filename.replace(filename.size() - 4, 4, ext);
-        if (PanicYesNoFmtT("Memory Card filename in Slot {0} is incorrect\n"
-                           "Region not specified\n\n"
-                           "Slot {1} path was changed to\n"
-                           "{2}\n"
-                           "Would you like to copy the old file to this new location?\n",
-                           is_slot_a ? 'A' : 'B', is_slot_a ? 'A' : 'B', filename))
-        {
-          if (!File::Copy(oldFilename, filename))
-            PanicAlertFmtT("Copy failed");
-        }
-      }
-      memcardPath = filename;  // Always correct the path!
-    }
-    else if (region.compare(gameRegion) != 0)
-    {
-      // filename has region, but it's not == gameRegion
-      // Just set the correct filename, the EXI Device will create it if it doesn't exist
-      memcardPath = filename.replace(filename.size() - ext.size(), ext.size(), ext);
-    }
-  }
-}
-
 void MemoryCard::FlushThread()
 {
   if (!Config::Get(Config::SESSION_SAVE_DATA_WRITABLE))
diff --git a/Source/Core/Core/HW/GCMemcard/GCMemcardRaw.h b/Source/Core/Core/HW/GCMemcard/GCMemcardRaw.h
index b8486c13a3..c6c85313e8 100644
--- a/Source/Core/Core/HW/GCMemcard/GCMemcardRaw.h
+++ b/Source/Core/Core/HW/GCMemcard/GCMemcardRaw.h
@@ -20,8 +20,6 @@ public:
   MemoryCard(const std::string& filename, ExpansionInterface::Slot card_slot,
              u16 size_mbits = Memcard::MBIT_SIZE_MEMORY_CARD_2043);
   ~MemoryCard();
-  static void CheckPath(std::string& memcardPath, const std::string& gameRegion,
-                        ExpansionInterface::Slot slot);
   void FlushThread();
   void MakeDirty();
 
diff --git a/Source/Core/Core/Movie.cpp b/Source/Core/Core/Movie.cpp
index 938a17f2eb..f988fc7e65 100644
--- a/Source/Core/Core/Movie.cpp
+++ b/Source/Core/Core/Movie.cpp
@@ -1479,6 +1479,9 @@ void GetSettings()
   }
   else
   {
+    const auto raw_memcard_exists = [](ExpansionInterface::Slot card_slot) {
+      return File::Exists(Config::GetMemcardPath(card_slot, SConfig::GetInstance().m_region));
+    };
     const auto gci_folder_has_saves = [](ExpansionInterface::Slot card_slot) {
       const auto [path, migrate] = ExpansionInterface::CEXIMemoryCard::GetGCIFolderPath(
           card_slot, ExpansionInterface::AllowMovieFolder::No);
@@ -1486,11 +1489,10 @@ void GetSettings()
       return number_of_saves > 0;
     };
 
-    s_bClearSave =
-        !(slot_a_has_raw_memcard && File::Exists(Config::Get(Config::MAIN_MEMCARD_A_PATH))) &&
-        !(slot_b_has_raw_memcard && File::Exists(Config::Get(Config::MAIN_MEMCARD_B_PATH))) &&
-        !(slot_a_has_gci_folder && gci_folder_has_saves(ExpansionInterface::Slot::A)) &&
-        !(slot_b_has_gci_folder && gci_folder_has_saves(ExpansionInterface::Slot::B));
+    s_bClearSave = !(slot_a_has_raw_memcard && raw_memcard_exists(ExpansionInterface::Slot::A)) &&
+                   !(slot_b_has_raw_memcard && raw_memcard_exists(ExpansionInterface::Slot::B)) &&
+                   !(slot_a_has_gci_folder && gci_folder_has_saves(ExpansionInterface::Slot::A)) &&
+                   !(slot_b_has_gci_folder && gci_folder_has_saves(ExpansionInterface::Slot::B));
   }
   s_memcards |= (slot_a_has_raw_memcard || slot_a_has_gci_folder) << 0;
   s_memcards |= (slot_b_has_raw_memcard || slot_b_has_gci_folder) << 1;
diff --git a/Source/Core/Core/NetPlayServer.cpp b/Source/Core/Core/NetPlayServer.cpp
index 30a0311910..0ed2290b0d 100644
--- a/Source/Core/Core/NetPlayServer.cpp
+++ b/Source/Core/Core/NetPlayServer.cpp
@@ -1470,8 +1470,8 @@ bool NetPlayServer::StartGame()
 
   const sf::Uint64 initial_rtc = GetInitialNetPlayRTC();
 
-  const std::string region = SConfig::GetDirectoryForRegion(
-      SConfig::ToGameCubeRegion(m_dialog->FindGameFile(m_selected_game_identifier)->GetRegion()));
+  const std::string region = Config::GetDirectoryForRegion(
+      Config::ToGameCubeRegion(m_dialog->FindGameFile(m_selected_game_identifier)->GetRegion()));
 
   // sync GC SRAM with clients
   if (!g_SRAM_netplay_initialized)
@@ -1665,8 +1665,8 @@ bool NetPlayServer::SyncSaveData()
   if (save_count == 0)
     return true;
 
-  const std::string region =
-      SConfig::GetDirectoryForRegion(SConfig::ToGameCubeRegion(game->GetRegion()));
+  const auto game_region = game->GetRegion();
+  const std::string region = Config::GetDirectoryForRegion(Config::ToGameCubeRegion(game_region));
 
   for (ExpansionInterface::Slot slot : ExpansionInterface::MEMCARD_SLOTS)
   {
@@ -1674,17 +1674,12 @@ bool NetPlayServer::SyncSaveData()
 
     if (m_settings.m_EXIDevice[slot] == ExpansionInterface::EXIDeviceType::MemoryCard)
     {
-      std::string path = Config::Get(Config::GetInfoForMemcardPath(slot));
-
-      MemoryCard::CheckPath(path, region, slot);
-
       const int size_override = m_settings.m_MemcardSizeOverride;
-      if (size_override >= 0 && size_override <= 4)
-      {
-        path.insert(path.find_last_of('.'),
-                    fmt::format(".{}", Memcard::MbitToFreeBlocks(Memcard::MBIT_SIZE_MEMORY_CARD_59
-                                                                 << size_override)));
-      }
+      const u16 card_size_mbits =
+          size_override >= 0 && size_override <= 4 ?
+              static_cast<u16>(Memcard::MBIT_SIZE_MEMORY_CARD_59 << size_override) :
+              Memcard::MBIT_SIZE_MEMORY_CARD_2043;
+      const std::string path = Config::GetMemcardPath(slot, game_region, card_size_mbits);
 
       sf::Packet pac;
       pac << MessageID::SyncSaveData;
diff --git a/Source/Core/DolphinQt/GCMemcardManager.cpp b/Source/Core/DolphinQt/GCMemcardManager.cpp
index 83a6b231c3..ebfb919777 100644
--- a/Source/Core/DolphinQt/GCMemcardManager.cpp
+++ b/Source/Core/DolphinQt/GCMemcardManager.cpp
@@ -228,7 +228,8 @@ void GCMemcardManager::LoadDefaultMemcards()
       continue;
     }
 
-    const QString path = QString::fromStdString(Config::Get(Config::GetInfoForMemcardPath(slot)));
+    const QString path = QString::fromStdString(
+        Config::GetMemcardPath(slot, Config::Get(Config::MAIN_FALLBACK_REGION)));
     SetSlotFile(slot, path);
   }
 }
diff --git a/Source/Core/DolphinQt/GameList/GameList.cpp b/Source/Core/DolphinQt/GameList/GameList.cpp
index 03bc60e7b2..b2fdb46df2 100644
--- a/Source/Core/DolphinQt/GameList/GameList.cpp
+++ b/Source/Core/DolphinQt/GameList/GameList.cpp
@@ -713,7 +713,7 @@ void GameList::OpenGCSaveFolder()
     case ExpansionInterface::EXIDeviceType::MemoryCardFolder:
     {
       std::string path = StringFromFormat("%s/%s/%s", File::GetUserPath(D_GCUSER_IDX).c_str(),
-                                          SConfig::GetDirectoryForRegion(game->GetRegion()),
+                                          Config::GetDirectoryForRegion(game->GetRegion()),
                                           slot == Slot::A ? "Card A" : "Card B");
 
       std::string override_path = Config::Get(Config::GetInfoForGCIPathOverride(slot));
@@ -734,7 +734,7 @@ void GameList::OpenGCSaveFolder()
     }
     case ExpansionInterface::EXIDeviceType::MemoryCard:
     {
-      std::string memcard_path = Config::Get(Config::GetInfoForMemcardPath(slot));
+      const std::string memcard_path = Config::GetMemcardPath(slot, game->GetRegion());
 
       std::string memcard_dir;
 
diff --git a/Source/Core/DolphinQt/MenuBar.cpp b/Source/Core/DolphinQt/MenuBar.cpp
index 1ace1276b8..a5b0adca99 100644
--- a/Source/Core/DolphinQt/MenuBar.cpp
+++ b/Source/Core/DolphinQt/MenuBar.cpp
@@ -1001,12 +1001,9 @@ void MenuBar::UpdateToolsMenu(bool emulation_started)
 {
   m_boot_sysmenu->setEnabled(!emulation_started);
   m_perform_online_update_menu->setEnabled(!emulation_started);
-  m_ntscj_ipl->setEnabled(!emulation_started &&
-                          File::Exists(SConfig::GetInstance().GetBootROMPath(JAP_DIR)));
-  m_ntscu_ipl->setEnabled(!emulation_started &&
-                          File::Exists(SConfig::GetInstance().GetBootROMPath(USA_DIR)));
-  m_pal_ipl->setEnabled(!emulation_started &&
-                        File::Exists(SConfig::GetInstance().GetBootROMPath(EUR_DIR)));
+  m_ntscj_ipl->setEnabled(!emulation_started && File::Exists(Config::GetBootROMPath(JAP_DIR)));
+  m_ntscu_ipl->setEnabled(!emulation_started && File::Exists(Config::GetBootROMPath(USA_DIR)));
+  m_pal_ipl->setEnabled(!emulation_started && File::Exists(Config::GetBootROMPath(EUR_DIR)));
   m_import_backup->setEnabled(!emulation_started);
   m_check_nand->setEnabled(!emulation_started);
 
diff --git a/Source/Core/DolphinQt/Settings/GameCubePane.cpp b/Source/Core/DolphinQt/Settings/GameCubePane.cpp
index 208535b8ae..82aea64a23 100644
--- a/Source/Core/DolphinQt/Settings/GameCubePane.cpp
+++ b/Source/Core/DolphinQt/Settings/GameCubePane.cpp
@@ -303,66 +303,89 @@ void GameCubePane::BrowseMemcard(ExpansionInterface::Slot slot)
 {
   ASSERT(ExpansionInterface::IsMemcardSlot(slot));
 
-  QString filename = DolphinFileDialog::getSaveFileName(
-      this, tr("Choose a file to open"), QString::fromStdString(File::GetUserPath(D_GCUSER_IDX)),
+  const QString filename = DolphinFileDialog::getSaveFileName(
+      this, tr("Choose a file to open or create"),
+      QString::fromStdString(File::GetUserPath(D_GCUSER_IDX)),
       tr("GameCube Memory Cards (*.raw *.gcp)"), 0, QFileDialog::DontConfirmOverwrite);
 
   if (filename.isEmpty())
     return;
 
-  QString path_abs = QFileInfo(filename).absoluteFilePath();
+  const std::string raw_path =
+      WithUnifiedPathSeparators(QFileInfo(filename).absoluteFilePath().toStdString());
 
-  // Memcard validity checks
-  if (File::Exists(filename.toStdString()))
+  // Figure out if the user selected a card that has a valid region specifier in the filename.
+  const std::string jp_path = Config::GetMemcardPath(raw_path, slot, DiscIO::Region::NTSC_J);
+  const std::string us_path = Config::GetMemcardPath(raw_path, slot, DiscIO::Region::NTSC_U);
+  const std::string eu_path = Config::GetMemcardPath(raw_path, slot, DiscIO::Region::PAL);
+  const bool raw_path_valid = raw_path == jp_path || raw_path == us_path || raw_path == eu_path;
+
+  if (!raw_path_valid)
   {
-    auto [error_code, mc] = Memcard::GCMemcard::Open(filename.toStdString());
-
-    if (error_code.HasCriticalErrors() || !mc || !mc->IsValid())
-    {
-      ModalMessageBox::critical(
-          this, tr("Error"),
-          tr("The file\n%1\nis either corrupted or not a GameCube memory card file.\n%2")
-              .arg(filename)
-              .arg(GCMemcardManager::GetErrorMessagesForErrorCode(error_code)));
-      return;
-    }
+    // TODO: We could try to autodetect the card region here and offer automatic renaming.
+    ModalMessageBox::critical(this, tr("Error"),
+                              tr("The filename %1 does not conform to Dolphin's region code format "
+                                 "for memory cards. Please rename this file to either %2, %3, or "
+                                 "%4, matching the region of the save files that are on it.")
+                                  .arg(QString::fromStdString(PathToFileName(raw_path)))
+                                  .arg(QString::fromStdString(PathToFileName(us_path)))
+                                  .arg(QString::fromStdString(PathToFileName(eu_path)))
+                                  .arg(QString::fromStdString(PathToFileName(jp_path))));
+    return;
   }
 
-  for (ExpansionInterface::Slot other_slot : ExpansionInterface::MEMCARD_SLOTS)
+  // Memcard validity checks
+  for (const std::string& path : {jp_path, us_path, eu_path})
   {
-    if (other_slot == slot)
-      continue;
-
-    bool other_slot_memcard = m_slot_combos[other_slot]->currentData().toInt() ==
-                              static_cast<int>(ExpansionInterface::EXIDeviceType::MemoryCard);
-    if (other_slot_memcard)
+    if (File::Exists(path))
     {
-      QString path_other =
-          QFileInfo(QString::fromStdString(Config::Get(Config::GetInfoForMemcardPath(other_slot))))
-              .absoluteFilePath();
+      auto [error_code, mc] = Memcard::GCMemcard::Open(path);
 
-      if (path_abs == path_other)
+      if (error_code.HasCriticalErrors() || !mc || !mc->IsValid())
       {
         ModalMessageBox::critical(
             this, tr("Error"),
-            tr("The same file can't be used in multiple slots; it is already used by %1.")
-                .arg(QString::fromStdString(fmt::to_string(other_slot))));
+            tr("The file\n%1\nis either corrupted or not a GameCube memory card file.\n%2")
+                .arg(QString::fromStdString(path))
+                .arg(GCMemcardManager::GetErrorMessagesForErrorCode(error_code)));
         return;
       }
     }
   }
 
-  QString path_old =
-      QFileInfo(QString::fromStdString(Config::Get(Config::GetInfoForMemcardPath(slot))))
-          .absoluteFilePath();
-
-  Config::SetBase(Config::GetInfoForMemcardPath(slot), path_abs.toStdString());
-
-  if (Core::IsRunning() && path_abs != path_old)
+  // Check if the other slot has the same memory card configured and refuse to use this card if so.
+  // The EU path is compared here, but it doesn't actually matter which one we compare since they
+  // follow a known pattern, so if the EU path matches the other match too and vice-versa.
+  for (ExpansionInterface::Slot other_slot : ExpansionInterface::MEMCARD_SLOTS)
   {
-    // ChangeDevice unplugs the device for 1 second, which means that games should notice that
-    // the path has changed and thus the memory card contents have changed
-    ExpansionInterface::ChangeDevice(slot, ExpansionInterface::EXIDeviceType::MemoryCard);
+    if (other_slot == slot)
+      continue;
+
+    const std::string other_eu_path = Config::GetMemcardPath(other_slot, DiscIO::Region::PAL);
+    if (eu_path == other_eu_path)
+    {
+      ModalMessageBox::critical(
+          this, tr("Error"),
+          tr("The same file can't be used in multiple slots; it is already used by %1.")
+              .arg(QString::fromStdString(fmt::to_string(other_slot))));
+      return;
+    }
+  }
+
+  Config::SetBase(Config::GetInfoForMemcardPath(slot), raw_path);
+
+  if (Core::IsRunning())
+  {
+    // If emulation is running and the new card is different from the old one, notify the system to
+    // eject the old and insert the new card.
+    // TODO: This should probably done by a config change callback instead.
+    const std::string old_eu_path = Config::GetMemcardPath(slot, DiscIO::Region::PAL);
+    if (eu_path != old_eu_path)
+    {
+      // ChangeDevice unplugs the device for 1 second, which means that games should notice that
+      // the path has changed and thus the memory card contents have changed
+      ExpansionInterface::ChangeDevice(slot, ExpansionInterface::EXIDeviceType::MemoryCard);
+    }
   }
 }