diff --git a/Source/Core/VideoBackends/D3D/TextureCache.h b/Source/Core/VideoBackends/D3D/TextureCache.h
index 85cc641812..9fc5d0876c 100644
--- a/Source/Core/VideoBackends/D3D/TextureCache.h
+++ b/Source/Core/VideoBackends/D3D/TextureCache.h
@@ -58,7 +58,7 @@ private:
                u32 memory_stride, PEControl::PixelFormat srcFormat, const EFBRectangle& srcRect,
                bool isIntensity, bool scaleByHalf) override;
 
-  void CompileShaders() override {}
+  bool CompileShaders() override { return true; }
   void DeleteShaders() override {}
   ID3D11Buffer* palette_buf;
   ID3D11ShaderResourceView* palette_buf_srv;
diff --git a/Source/Core/VideoBackends/D3D12/TextureCache.h b/Source/Core/VideoBackends/D3D12/TextureCache.h
index 4cce8a75b0..d8b20a4911 100644
--- a/Source/Core/VideoBackends/D3D12/TextureCache.h
+++ b/Source/Core/VideoBackends/D3D12/TextureCache.h
@@ -65,7 +65,7 @@ private:
                u32 memory_stride, PEControl::PixelFormat src_format, const EFBRectangle& src_rect,
                bool is_intensity, bool scale_by_half) override;
 
-  void CompileShaders() override {}
+  bool CompileShaders() override { return true; }
   void DeleteShaders() override {}
   std::unique_ptr<D3DStreamBuffer> m_palette_stream_buffer;
 
diff --git a/Source/Core/VideoBackends/Null/TextureCache.h b/Source/Core/VideoBackends/Null/TextureCache.h
index d6ee5b3b7c..7c51133c6a 100644
--- a/Source/Core/VideoBackends/Null/TextureCache.h
+++ b/Source/Core/VideoBackends/Null/TextureCache.h
@@ -13,7 +13,7 @@ class TextureCache : public TextureCacheBase
 public:
   TextureCache() {}
   ~TextureCache() {}
-  void CompileShaders() override {}
+  bool CompileShaders() override { return true; }
   void DeleteShaders() override {}
   void ConvertTexture(TCacheEntryBase* entry, TCacheEntryBase* unconverted, void* palette,
                       TlutFormat format) override
diff --git a/Source/Core/VideoBackends/OGL/TextureCache.cpp b/Source/Core/VideoBackends/OGL/TextureCache.cpp
index 6643e6b9cd..dc9d290f3e 100644
--- a/Source/Core/VideoBackends/OGL/TextureCache.cpp
+++ b/Source/Core/VideoBackends/OGL/TextureCache.cpp
@@ -314,7 +314,7 @@ void TextureCache::SetStage()
     glActiveTexture(GL_TEXTURE0 + s_ActiveTexture);
 }
 
-void TextureCache::CompileShaders()
+bool TextureCache::CompileShaders()
 {
   constexpr const char* color_copy_program = "SAMPLER_BINDING(9) uniform sampler2DArray samp9;\n"
                                              "in vec3 f_uv0;\n"
@@ -398,15 +398,18 @@ void TextureCache::CompileShaders()
   const char* prefix = geo_program.empty() ? "f" : "v";
   const char* depth_layer = g_ActiveConfig.bStereoEFBMonoDepth ? "0.0" : "f_uv0.z";
 
-  ProgramShaderCache::CompileShader(s_ColorCopyProgram,
-                                    StringFromFormat(vertex_program, prefix, prefix),
-                                    color_copy_program, geo_program);
-  ProgramShaderCache::CompileShader(s_ColorMatrixProgram,
-                                    StringFromFormat(vertex_program, prefix, prefix),
-                                    color_matrix_program, geo_program);
-  ProgramShaderCache::CompileShader(
-      s_DepthMatrixProgram, StringFromFormat(vertex_program, prefix, prefix),
-      StringFromFormat(depth_matrix_program, depth_layer), geo_program);
+  if (!ProgramShaderCache::CompileShader(s_ColorCopyProgram,
+                                         StringFromFormat(vertex_program, prefix, prefix),
+                                         color_copy_program, geo_program) ||
+      !ProgramShaderCache::CompileShader(s_ColorMatrixProgram,
+                                         StringFromFormat(vertex_program, prefix, prefix),
+                                         color_matrix_program, geo_program) ||
+      !ProgramShaderCache::CompileShader(
+          s_DepthMatrixProgram, StringFromFormat(vertex_program, prefix, prefix),
+          StringFromFormat(depth_matrix_program, depth_layer), geo_program))
+  {
+    return false;
+  }
 
   s_ColorMatrixUniform = glGetUniformLocation(s_ColorMatrixProgram.glprogid, "colmat");
   s_DepthMatrixUniform = glGetUniformLocation(s_DepthMatrixProgram.glprogid, "colmat");
@@ -500,9 +503,12 @@ void TextureCache::CompileShaders()
 
   if (g_ActiveConfig.backend_info.bSupportsPaletteConversion)
   {
-    ProgramShaderCache::CompileShader(
-        s_palette_pixel_shader[GX_TL_IA8], StringFromFormat(vertex_program, prefix, prefix),
-        "#define DECODE DecodePixel_IA8" + palette_shader, geo_program);
+    if (!ProgramShaderCache::CompileShader(
+            s_palette_pixel_shader[GX_TL_IA8], StringFromFormat(vertex_program, prefix, prefix),
+            "#define DECODE DecodePixel_IA8" + palette_shader, geo_program))
+    {
+      return false;
+    }
     s_palette_buffer_offset_uniform[GX_TL_IA8] =
         glGetUniformLocation(s_palette_pixel_shader[GX_TL_IA8].glprogid, "texture_buffer_offset");
     s_palette_multiplier_uniform[GX_TL_IA8] =
@@ -510,9 +516,12 @@ void TextureCache::CompileShaders()
     s_palette_copy_position_uniform[GX_TL_IA8] =
         glGetUniformLocation(s_palette_pixel_shader[GX_TL_IA8].glprogid, "copy_position");
 
-    ProgramShaderCache::CompileShader(
-        s_palette_pixel_shader[GX_TL_RGB565], StringFromFormat(vertex_program, prefix, prefix),
-        "#define DECODE DecodePixel_RGB565" + palette_shader, geo_program);
+    if (!ProgramShaderCache::CompileShader(
+            s_palette_pixel_shader[GX_TL_RGB565], StringFromFormat(vertex_program, prefix, prefix),
+            "#define DECODE DecodePixel_RGB565" + palette_shader, geo_program))
+    {
+      return false;
+    }
     s_palette_buffer_offset_uniform[GX_TL_RGB565] = glGetUniformLocation(
         s_palette_pixel_shader[GX_TL_RGB565].glprogid, "texture_buffer_offset");
     s_palette_multiplier_uniform[GX_TL_RGB565] =
@@ -520,9 +529,12 @@ void TextureCache::CompileShaders()
     s_palette_copy_position_uniform[GX_TL_RGB565] =
         glGetUniformLocation(s_palette_pixel_shader[GX_TL_RGB565].glprogid, "copy_position");
 
-    ProgramShaderCache::CompileShader(
-        s_palette_pixel_shader[GX_TL_RGB5A3], StringFromFormat(vertex_program, prefix, prefix),
-        "#define DECODE DecodePixel_RGB5A3" + palette_shader, geo_program);
+    if (!ProgramShaderCache::CompileShader(
+            s_palette_pixel_shader[GX_TL_RGB5A3], StringFromFormat(vertex_program, prefix, prefix),
+            "#define DECODE DecodePixel_RGB5A3" + palette_shader, geo_program))
+    {
+      return false;
+    }
     s_palette_buffer_offset_uniform[GX_TL_RGB5A3] = glGetUniformLocation(
         s_palette_pixel_shader[GX_TL_RGB5A3].glprogid, "texture_buffer_offset");
     s_palette_multiplier_uniform[GX_TL_RGB5A3] =
@@ -530,6 +542,8 @@ void TextureCache::CompileShaders()
     s_palette_copy_position_uniform[GX_TL_RGB5A3] =
         glGetUniformLocation(s_palette_pixel_shader[GX_TL_RGB5A3].glprogid, "copy_position");
   }
+
+  return true;
 }
 
 void TextureCache::DeleteShaders()
diff --git a/Source/Core/VideoBackends/OGL/TextureCache.h b/Source/Core/VideoBackends/OGL/TextureCache.h
index ecd9056127..0007cf1deb 100644
--- a/Source/Core/VideoBackends/OGL/TextureCache.h
+++ b/Source/Core/VideoBackends/OGL/TextureCache.h
@@ -57,7 +57,7 @@ private:
                u32 memory_stride, PEControl::PixelFormat srcFormat, const EFBRectangle& srcRect,
                bool isIntensity, bool scaleByHalf) override;
 
-  void CompileShaders() override;
+  bool CompileShaders() override;
   void DeleteShaders() override;
 };
 
diff --git a/Source/Core/VideoBackends/Software/SWmain.cpp b/Source/Core/VideoBackends/Software/SWmain.cpp
index 47bfa694bf..ebac32de3a 100644
--- a/Source/Core/VideoBackends/Software/SWmain.cpp
+++ b/Source/Core/VideoBackends/Software/SWmain.cpp
@@ -47,10 +47,12 @@ public:
 class TextureCache : public TextureCacheBase
 {
 public:
-  void CompileShaders() override{};
-  void DeleteShaders() override{};
+  bool CompileShaders() override { return true; }
+  void DeleteShaders() override {}
   void ConvertTexture(TCacheEntryBase* entry, TCacheEntryBase* unconverted, void* palette,
-                      TlutFormat format) override{};
+                      TlutFormat format) override
+  {
+  }
   void CopyEFB(u8* dst, u32 format, u32 native_width, u32 bytes_per_row, u32 num_blocks_y,
                u32 memory_stride, PEControl::PixelFormat srcFormat, const EFBRectangle& srcRect,
                bool isIntensity, bool scaleByHalf) override
diff --git a/Source/Core/VideoCommon/TextureCacheBase.cpp b/Source/Core/VideoCommon/TextureCacheBase.cpp
index ab260aedd7..39af7f155c 100644
--- a/Source/Core/VideoCommon/TextureCacheBase.cpp
+++ b/Source/Core/VideoCommon/TextureCacheBase.cpp
@@ -133,7 +133,8 @@ void TextureCacheBase::OnConfigChanged(VideoConfig& config)
         config.bStereoEFBMonoDepth != backup_config.s_efb_mono_depth)
     {
       g_texture_cache->DeleteShaders();
-      g_texture_cache->CompileShaders();
+      if (!g_texture_cache->CompileShaders())
+        PanicAlert("Failed to recompile one or more texture conversion shaders.");
     }
   }
 
diff --git a/Source/Core/VideoCommon/TextureCacheBase.h b/Source/Core/VideoCommon/TextureCacheBase.h
index b3bde3bb0d..e10a0439f1 100644
--- a/Source/Core/VideoCommon/TextureCacheBase.h
+++ b/Source/Core/VideoCommon/TextureCacheBase.h
@@ -160,8 +160,8 @@ public:
                        u32 memory_stride, PEControl::PixelFormat srcFormat,
                        const EFBRectangle& srcRect, bool isIntensity, bool scaleByHalf) = 0;
 
-  virtual void CompileShaders() = 0;  // currently only implemented by OGL
-  virtual void DeleteShaders() = 0;   // currently only implemented by OGL
+  virtual bool CompileShaders() = 0;
+  virtual void DeleteShaders() = 0;
 
   static TCacheEntryBase* Load(const u32 stage);
   static void UnbindTextures();