diff --git a/CMakeLists.txt b/CMakeLists.txt
index e8d484e68a..37e4f14f5e 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -6,8 +6,12 @@ cmake_minimum_required(VERSION 2.6)
 # Update compiler before calling project()
 if (APPLE)
 	# Use clang compiler
-	set(CMAKE_C_COMPILER "clang")
-	set(CMAKE_CXX_COMPILER "clang++")
+	set(CMAKE_C_COMPILER "/Applications/Xcode.app/Contents/Developer/Toolchains/XcodeDefault.xctoolchain/usr/bin/clang")
+	set(CMAKE_CXX_COMPILER "/Applications/Xcode.app/Contents/Developer/Toolchains/XcodeDefault.xctoolchain/usr/bin/clang++")
+	if (NOT EXISTS "${CMAKE_CXX_COMPILER}")
+		set(CMAKE_C_COMPILER "clang")
+		set(CMAKE_CXX_COMPILER "clang++")
+	endif()
 endif()
 project(dolphin-emu)
 set(CMAKE_MODULE_PATH ${CMAKE_MODULE_PATH} ${CMAKE_SOURCE_DIR}/CMakeTests)
@@ -122,6 +126,10 @@ if(UNIX AND NOT APPLE)
 endif()
 
 if(APPLE)
+	# Ignore MacPorts and Fink and any other locally installed packages that
+	# might prevent building a distributable binary.
+	set(CMAKE_SYSTEM_PREFIX_PATH /usr)
+	set(ENV{PATH} /usr/bin:/bin:/usr/sbin:/sbin)
 
 	# Some of our code contains Objective C constructs.
 	set(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -x objective-c")
@@ -136,7 +144,7 @@ if(APPLE)
 	# This is inserted into the Info.plist as well.
 	# Note that the SDK determines the maximum version of which optional
 	# features can be used, not the minimum required version to run.
-	set(OSX_MIN_VERSION "10.6")
+	set(OSX_MIN_VERSION "10.5.4")
 	set(TARGET_FLAGS "${TARGET_FLAGS} -mmacosx-version-min=${OSX_MIN_VERSION}")
 	set(SYSROOT_LEGACY_PATH "/Developer/SDKs/MacOSX10.6.sdk")
 	set(SYSROOT_PATH "/Applications/Xcode.app/Contents/Developer/Platforms/MacOSX.platform/Developer/SDKs/MacOSX10.6.sdk")
@@ -145,9 +153,9 @@ if(APPLE)
 	elseif(EXISTS "${SYSROOT_LEGACY_PATH}/")
         set(TARGET_SYSROOT ${SYSROOT_LEGACY_PATH})
 	endif()
-	if(TARGET_SYSROOT)
+	if(${TARGET_SYSROOT})
         set(TARGET_FLAGS "${TARGET_FLAGS} -isysroot ${TARGET_SYSROOT}")
-        set(CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -mmacosx-version-min=${OSX_MIN_VERSION} -Wl,-syslibroot,${TARGET_SYSROOT}")
+        set(CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -Wl,-syslibroot,${TARGET_SYSROOT}")
 	endif()
 	# Do not warn about frameworks that are not available on all architectures.
 	# This avoids a warning when linking with QuickTime.
@@ -480,7 +488,7 @@ endif()
 option(DISABLE_WX "Disable wxWidgets (use CLI interface)" OFF)
 if(NOT DISABLE_WX)
 	include(FindwxWidgets OPTIONAL)
-	FIND_PACKAGE(wxWidgets COMPONENTS core aui adv gl)
+	FIND_PACKAGE(wxWidgets COMPONENTS core aui adv)
 
 	if(wxWidgets_FOUND)
 		EXECUTE_PROCESS(