diff --git a/Source/Core/VideoBackends/D3D/DXTexture.cpp b/Source/Core/VideoBackends/D3D/DXTexture.cpp
index 4f0dec113f..127a922146 100644
--- a/Source/Core/VideoBackends/D3D/DXTexture.cpp
+++ b/Source/Core/VideoBackends/D3D/DXTexture.cpp
@@ -49,6 +49,8 @@ DXGI_FORMAT GetDXGIFormatForHostFormat(AbstractTextureFormat format)
     return DXGI_FORMAT_R32_FLOAT;
   case AbstractTextureFormat::D16:
     return DXGI_FORMAT_R16_TYPELESS;
+  case AbstractTextureFormat::D24_S8:
+    return DXGI_FORMAT_R24G8_TYPELESS;
   case AbstractTextureFormat::D32F:
     return DXGI_FORMAT_R32_TYPELESS;
   case AbstractTextureFormat::D32F_S8:
@@ -64,6 +66,8 @@ DXGI_FORMAT GetSRVFormatForHostFormat(AbstractTextureFormat format)
   {
   case AbstractTextureFormat::D16:
     return DXGI_FORMAT_R16_UNORM;
+  case AbstractTextureFormat::D24_S8:
+    return DXGI_FORMAT_R24_UNORM_X8_TYPELESS;
   case AbstractTextureFormat::D32F:
     return DXGI_FORMAT_R32_FLOAT;
   case AbstractTextureFormat::D32F_S8:
@@ -78,6 +82,8 @@ DXGI_FORMAT GetDSVFormatForHostFormat(AbstractTextureFormat format)
   {
   case AbstractTextureFormat::D16:
     return DXGI_FORMAT_D16_UNORM;
+  case AbstractTextureFormat::D24_S8:
+    return DXGI_FORMAT_D24_UNORM_S8_UINT;
   case AbstractTextureFormat::D32F:
     return DXGI_FORMAT_D32_FLOAT;
   case AbstractTextureFormat::D32F_S8:
diff --git a/Source/Core/VideoBackends/OGL/OGLTexture.cpp b/Source/Core/VideoBackends/OGL/OGLTexture.cpp
index 4ce9aa398c..5399a11d04 100644
--- a/Source/Core/VideoBackends/OGL/OGLTexture.cpp
+++ b/Source/Core/VideoBackends/OGL/OGLTexture.cpp
@@ -41,6 +41,8 @@ GLenum GetGLInternalFormatForTextureFormat(AbstractTextureFormat format, bool st
     return GL_R32F;
   case AbstractTextureFormat::D16:
     return GL_DEPTH_COMPONENT16;
+  case AbstractTextureFormat::D24_S8:
+    return GL_DEPTH24_STENCIL8;
   case AbstractTextureFormat::D32F:
     return GL_DEPTH_COMPONENT32F;
   case AbstractTextureFormat::D32F_S8:
@@ -65,6 +67,7 @@ GLenum GetGLFormatForTextureFormat(AbstractTextureFormat format)
   case AbstractTextureFormat::D16:
   case AbstractTextureFormat::D32F:
     return GL_DEPTH_COMPONENT;
+  case AbstractTextureFormat::D24_S8:
   case AbstractTextureFormat::D32F_S8:
     return GL_DEPTH_STENCIL;
   // Compressed texture formats don't use this parameter.
@@ -86,6 +89,8 @@ GLenum GetGLTypeForTextureFormat(AbstractTextureFormat format)
     return GL_FLOAT;
   case AbstractTextureFormat::D16:
     return GL_UNSIGNED_SHORT;
+  case AbstractTextureFormat::D24_S8:
+    return GL_UNSIGNED_INT_24_8;
   case AbstractTextureFormat::D32F:
     return GL_FLOAT;
   case AbstractTextureFormat::D32F_S8:
diff --git a/Source/Core/VideoBackends/Vulkan/FramebufferManager.cpp b/Source/Core/VideoBackends/Vulkan/FramebufferManager.cpp
index 1713b0c514..27eeeb58ba 100644
--- a/Source/Core/VideoBackends/Vulkan/FramebufferManager.cpp
+++ b/Source/Core/VideoBackends/Vulkan/FramebufferManager.cpp
@@ -142,12 +142,12 @@ bool FramebufferManager::Initialize()
 
 bool FramebufferManager::CreateEFBRenderPasses()
 {
-  m_efb_load_render_pass =
-      g_object_cache->GetRenderPass(EFB_COLOR_TEXTURE_FORMAT, EFB_DEPTH_TEXTURE_FORMAT,
-                                    g_ActiveConfig.iMultisamples, VK_ATTACHMENT_LOAD_OP_LOAD);
-  m_efb_clear_render_pass =
-      g_object_cache->GetRenderPass(EFB_COLOR_TEXTURE_FORMAT, EFB_DEPTH_TEXTURE_FORMAT,
-                                    g_ActiveConfig.iMultisamples, VK_ATTACHMENT_LOAD_OP_CLEAR);
+  m_efb_load_render_pass = g_object_cache->GetRenderPass(
+      EFB_COLOR_TEXTURE_FORMAT, Util::GetVkFormatForHostTextureFormat(GetEFBDepthFormat()),
+      g_ActiveConfig.iMultisamples, VK_ATTACHMENT_LOAD_OP_LOAD);
+  m_efb_clear_render_pass = g_object_cache->GetRenderPass(
+      EFB_COLOR_TEXTURE_FORMAT, Util::GetVkFormatForHostTextureFormat(GetEFBDepthFormat()),
+      g_ActiveConfig.iMultisamples, VK_ATTACHMENT_LOAD_OP_CLEAR);
   m_depth_resolve_render_pass = g_object_cache->GetRenderPass(
       EFB_DEPTH_AS_COLOR_TEXTURE_FORMAT, VK_FORMAT_UNDEFINED, 1, VK_ATTACHMENT_LOAD_OP_DONT_CARE);
   return m_efb_load_render_pass != VK_NULL_HANDLE && m_efb_clear_render_pass != VK_NULL_HANDLE &&
@@ -181,7 +181,8 @@ bool FramebufferManager::CreateEFBFramebuffer()
                             VK_IMAGE_USAGE_COLOR_ATTACHMENT_BIT | VK_IMAGE_USAGE_SAMPLED_BIT);
 
   m_efb_depth_texture = Texture2D::Create(
-      efb_width, efb_height, 1, efb_layers, EFB_DEPTH_TEXTURE_FORMAT, efb_samples,
+      efb_width, efb_height, 1, efb_layers,
+      Util::GetVkFormatForHostTextureFormat(GetEFBDepthFormat()), efb_samples,
       VK_IMAGE_VIEW_TYPE_2D_ARRAY, VK_IMAGE_TILING_OPTIMAL,
       VK_IMAGE_USAGE_TRANSFER_SRC_BIT | VK_IMAGE_USAGE_TRANSFER_DST_BIT |
           VK_IMAGE_USAGE_DEPTH_STENCIL_ATTACHMENT_BIT | VK_IMAGE_USAGE_SAMPLED_BIT);
diff --git a/Source/Core/VideoBackends/Vulkan/Texture2D.cpp b/Source/Core/VideoBackends/Vulkan/Texture2D.cpp
index 39eb9bfcd8..96bfba6538 100644
--- a/Source/Core/VideoBackends/Vulkan/Texture2D.cpp
+++ b/Source/Core/VideoBackends/Vulkan/Texture2D.cpp
@@ -169,9 +169,8 @@ void Texture2D::TransitionToLayout(VkCommandBuffer command_buffer, VkImageLayout
       VK_QUEUE_FAMILY_IGNORED,                 // uint32_t                   srcQueueFamilyIndex
       VK_QUEUE_FAMILY_IGNORED,                 // uint32_t                   dstQueueFamilyIndex
       m_image,                                 // VkImage                    image
-      {static_cast<VkImageAspectFlags>(Util::IsDepthFormat(m_format) ? VK_IMAGE_ASPECT_DEPTH_BIT :
-                                                                       VK_IMAGE_ASPECT_COLOR_BIT),
-       0, m_levels, 0, m_layers}  // VkImageSubresourceRange    subresourceRange
+      {Util::GetImageAspectForFormat(m_format), 0, m_levels, 0,
+       m_layers}  // VkImageSubresourceRange    subresourceRange
   };
 
   // srcStageMask -> Stages that must complete before the barrier
@@ -316,9 +315,8 @@ void Texture2D::TransitionToLayout(VkCommandBuffer command_buffer, ComputeImageL
       VK_QUEUE_FAMILY_IGNORED,                 // uint32_t                   srcQueueFamilyIndex
       VK_QUEUE_FAMILY_IGNORED,                 // uint32_t                   dstQueueFamilyIndex
       m_image,                                 // VkImage                    image
-      {static_cast<VkImageAspectFlags>(Util::IsDepthFormat(m_format) ? VK_IMAGE_ASPECT_DEPTH_BIT :
-                                                                       VK_IMAGE_ASPECT_COLOR_BIT),
-       0, m_levels, 0, m_layers}  // VkImageSubresourceRange    subresourceRange
+      {Util::GetImageAspectForFormat(m_format), 0, m_levels, 0,
+       m_layers}  // VkImageSubresourceRange    subresourceRange
   };
 
   VkPipelineStageFlags srcStageMask, dstStageMask;
diff --git a/Source/Core/VideoBackends/Vulkan/Util.cpp b/Source/Core/VideoBackends/Vulkan/Util.cpp
index 9e9060c5a3..4ffa5c0146 100644
--- a/Source/Core/VideoBackends/Vulkan/Util.cpp
+++ b/Source/Core/VideoBackends/Vulkan/Util.cpp
@@ -118,6 +118,9 @@ VkFormat GetVkFormatForHostTextureFormat(AbstractTextureFormat format)
   case AbstractTextureFormat::D16:
     return VK_FORMAT_D16_UNORM;
 
+  case AbstractTextureFormat::D24_S8:
+    return VK_FORMAT_D24_UNORM_S8_UINT;
+
   case AbstractTextureFormat::R32F:
     return VK_FORMAT_R32_SFLOAT;
 
@@ -133,6 +136,24 @@ VkFormat GetVkFormatForHostTextureFormat(AbstractTextureFormat format)
   }
 }
 
+VkImageAspectFlags GetImageAspectForFormat(VkFormat format)
+{
+  switch (format)
+  {
+  case VK_FORMAT_D16_UNORM_S8_UINT:
+  case VK_FORMAT_D24_UNORM_S8_UINT:
+  case VK_FORMAT_D32_SFLOAT_S8_UINT:
+    return VK_IMAGE_ASPECT_DEPTH_BIT | VK_IMAGE_ASPECT_STENCIL_BIT;
+
+  case VK_FORMAT_D16_UNORM:
+  case VK_FORMAT_D32_SFLOAT:
+    return VK_IMAGE_ASPECT_DEPTH_BIT;
+
+  default:
+    return VK_IMAGE_ASPECT_COLOR_BIT;
+  }
+}
+
 u32 GetTexelSize(VkFormat format)
 {
   // Only contains pixel formats we use.
diff --git a/Source/Core/VideoBackends/Vulkan/Util.h b/Source/Core/VideoBackends/Vulkan/Util.h
index 56d8d58ff0..ced63ef06b 100644
--- a/Source/Core/VideoBackends/Vulkan/Util.h
+++ b/Source/Core/VideoBackends/Vulkan/Util.h
@@ -29,6 +29,7 @@ bool IsDepthFormat(VkFormat format);
 bool IsCompressedFormat(VkFormat format);
 VkFormat GetLinearFormat(VkFormat format);
 VkFormat GetVkFormatForHostTextureFormat(AbstractTextureFormat format);
+VkImageAspectFlags GetImageAspectForFormat(VkFormat format);
 u32 GetTexelSize(VkFormat format);
 u32 GetBlockSize(VkFormat format);
 
diff --git a/Source/Core/VideoBackends/Vulkan/VKTexture.cpp b/Source/Core/VideoBackends/Vulkan/VKTexture.cpp
index cee60012a8..b3c111d5a2 100644
--- a/Source/Core/VideoBackends/Vulkan/VKTexture.cpp
+++ b/Source/Core/VideoBackends/Vulkan/VKTexture.cpp
@@ -94,8 +94,8 @@ std::unique_ptr<VKTexture> VKTexture::Create(const TextureConfig& tex_config)
     {
       // Clear render targets before use to prevent reading uninitialized memory.
       VkClearDepthStencilValue clear_value = {0.0f, 0};
-      VkImageSubresourceRange clear_range = {VK_IMAGE_ASPECT_DEPTH_BIT, 0, tex_config.levels, 0,
-                                             tex_config.layers};
+      VkImageSubresourceRange clear_range = {Util::GetImageAspectForFormat(vk_format), 0,
+                                             tex_config.levels, 0, tex_config.layers};
       texture->TransitionToLayout(g_command_buffer_mgr->GetCurrentInitCommandBuffer(),
                                   VK_IMAGE_LAYOUT_TRANSFER_DST_OPTIMAL);
       vkCmdClearDepthStencilImage(g_command_buffer_mgr->GetCurrentInitCommandBuffer(),
diff --git a/Source/Core/VideoCommon/AbstractTexture.cpp b/Source/Core/VideoCommon/AbstractTexture.cpp
index b01fbce085..6190f0e51b 100644
--- a/Source/Core/VideoCommon/AbstractTexture.cpp
+++ b/Source/Core/VideoCommon/AbstractTexture.cpp
@@ -69,6 +69,7 @@ bool AbstractTexture::IsDepthFormat(AbstractTextureFormat format)
   switch (format)
   {
   case AbstractTextureFormat::D16:
+  case AbstractTextureFormat::D24_S8:
   case AbstractTextureFormat::D32F:
   case AbstractTextureFormat::D32F_S8:
     return true;
@@ -80,7 +81,7 @@ bool AbstractTexture::IsDepthFormat(AbstractTextureFormat format)
 
 bool AbstractTexture::IsStencilFormat(AbstractTextureFormat format)
 {
-  return format == AbstractTextureFormat::D32F_S8;
+  return format == AbstractTextureFormat::D24_S8 || format == AbstractTextureFormat::D32F_S8;
 }
 
 size_t AbstractTexture::CalculateStrideForFormat(AbstractTextureFormat format, u32 row_length)
@@ -100,6 +101,7 @@ size_t AbstractTexture::CalculateStrideForFormat(AbstractTextureFormat format, u
   case AbstractTextureFormat::BGRA8:
   case AbstractTextureFormat::R32F:
   case AbstractTextureFormat::D32F:
+  case AbstractTextureFormat::D24_S8:
     return static_cast<size_t>(row_length) * 4;
   case AbstractTextureFormat::D32F_S8:
     return static_cast<size_t>(row_length) * 8;
@@ -124,6 +126,7 @@ size_t AbstractTexture::GetTexelSizeForFormat(AbstractTextureFormat format)
     return 2;
   case AbstractTextureFormat::RGBA8:
   case AbstractTextureFormat::BGRA8:
+  case AbstractTextureFormat::D24_S8:
   case AbstractTextureFormat::R32F:
   case AbstractTextureFormat::D32F:
     return 4;
diff --git a/Source/Core/VideoCommon/DriverDetails.cpp b/Source/Core/VideoCommon/DriverDetails.cpp
index 1626e24d18..301c73d89f 100644
--- a/Source/Core/VideoCommon/DriverDetails.cpp
+++ b/Source/Core/VideoCommon/DriverDetails.cpp
@@ -108,7 +108,8 @@ static BugInfo m_known_bugs[] = {
      -1.0, true},
     {API_VULKAN, OS_ALL, VENDOR_IMGTEC, DRIVER_IMGTEC, Family::UNKNOWN,
      BUG_BROKEN_CLEAR_LOADOP_RENDERPASS, -1.0, -1.0, true},
-};
+    {API_VULKAN, OS_ALL, VENDOR_QUALCOMM, DRIVER_QUALCOMM, Family::UNKNOWN, BUG_BROKEN_D32F_CLEAR,
+     -1.0, -1.0, true}};
 
 static std::map<Bug, BugInfo> m_bugs;
 
diff --git a/Source/Core/VideoCommon/DriverDetails.h b/Source/Core/VideoCommon/DriverDetails.h
index 65b6c89fcb..9ace5f83b4 100644
--- a/Source/Core/VideoCommon/DriverDetails.h
+++ b/Source/Core/VideoCommon/DriverDetails.h
@@ -269,6 +269,13 @@ enum Bug
   // Started Version: 1.7
   // Ended Version: 1.10
   BUG_BROKEN_CLEAR_LOADOP_RENDERPASS,
+
+  // BUG: 32-bit depth clears are broken in the Adreno Vulkan driver, and have no effect.
+  // To work around this, we use a D24_S8 buffer instead, which results in a loss of accuracy.
+  // We still resolve this to a R32F texture, as there is no 24-bit format.
+  // Started version: -1
+  // Ended version: -1
+  BUG_BROKEN_D32F_CLEAR,
 };
 
 // Initializes our internal vendor, device family, and driver version
diff --git a/Source/Core/VideoCommon/FramebufferManagerBase.cpp b/Source/Core/VideoCommon/FramebufferManagerBase.cpp
index af8ad87256..530aac7584 100644
--- a/Source/Core/VideoCommon/FramebufferManagerBase.cpp
+++ b/Source/Core/VideoCommon/FramebufferManagerBase.cpp
@@ -6,6 +6,8 @@
 
 #include <memory>
 
+#include "VideoCommon/AbstractTexture.h"
+#include "VideoCommon/DriverDetails.h"
 #include "VideoCommon/RenderBase.h"
 
 std::unique_ptr<FramebufferManagerBase> g_framebuffer_manager;
@@ -13,3 +15,14 @@ std::unique_ptr<FramebufferManagerBase> g_framebuffer_manager;
 unsigned int FramebufferManagerBase::m_EFBLayers = 1;
 
 FramebufferManagerBase::~FramebufferManagerBase() = default;
+
+AbstractTextureFormat FramebufferManagerBase::GetEFBDepthFormat()
+{
+  // 32-bit depth clears are broken in the Adreno Vulkan driver, and have no effect.
+  // To work around this, we use a D24_S8 buffer instead, which results in a loss of accuracy.
+  // We still resolve this to a R32F texture, as there is no 24-bit format.
+  if (DriverDetails::HasBug(DriverDetails::BUG_BROKEN_D32F_CLEAR))
+    return AbstractTextureFormat::D24_S8;
+  else
+    return AbstractTextureFormat::D32F;
+}
diff --git a/Source/Core/VideoCommon/FramebufferManagerBase.h b/Source/Core/VideoCommon/FramebufferManagerBase.h
index c77b741e41..ff9ff0cc2e 100644
--- a/Source/Core/VideoCommon/FramebufferManagerBase.h
+++ b/Source/Core/VideoCommon/FramebufferManagerBase.h
@@ -8,6 +8,8 @@
 
 #include "Common/CommonTypes.h"
 
+enum class AbstractTextureFormat : u32;
+
 inline bool AddressRangesOverlap(u32 aLower, u32 aUpper, u32 bLower, u32 bUpper)
 {
   return !((aLower >= bUpper) || (bLower >= aUpper));
@@ -19,6 +21,7 @@ public:
   virtual ~FramebufferManagerBase();
 
   static unsigned int GetEFBLayers() { return m_EFBLayers; }
+  static AbstractTextureFormat GetEFBDepthFormat();
 
 protected:
   static unsigned int m_EFBLayers;
diff --git a/Source/Core/VideoCommon/ShaderCache.cpp b/Source/Core/VideoCommon/ShaderCache.cpp
index 13b1bfc0fc..f369118962 100644
--- a/Source/Core/VideoCommon/ShaderCache.cpp
+++ b/Source/Core/VideoCommon/ShaderCache.cpp
@@ -10,6 +10,7 @@
 #include "Core/ConfigManager.h"
 #include "Core/Host.h"
 
+#include "VideoCommon/FramebufferManagerBase.h"
 #include "VideoCommon/RenderBase.h"
 #include "VideoCommon/Statistics.h"
 #include "VideoCommon/VertexLoaderManager.h"
@@ -26,6 +27,7 @@ bool ShaderCache::Initialize()
 {
   m_api_type = g_ActiveConfig.backend_info.api_type;
   m_host_config = ShaderHostConfig::GetCurrent();
+  m_efb_depth_format = FramebufferManagerBase::GetEFBDepthFormat();
   m_efb_multisamples = g_ActiveConfig.iMultisamples;
 
   // Create the async compiler, and start the worker threads.
@@ -441,7 +443,7 @@ AbstractPipelineConfig ShaderCache::GetGXPipelineConfig(
   config.depth_state = depth_state;
   config.blending_state = blending_state;
   config.framebuffer_state.color_texture_format = AbstractTextureFormat::RGBA8;
-  config.framebuffer_state.depth_texture_format = AbstractTextureFormat::D32F;
+  config.framebuffer_state.depth_texture_format = m_efb_depth_format;
   config.framebuffer_state.per_sample_shading = m_host_config.ssaa;
   config.framebuffer_state.samples = m_efb_multisamples;
   return config;
diff --git a/Source/Core/VideoCommon/ShaderCache.h b/Source/Core/VideoCommon/ShaderCache.h
index c1a8b06367..a91559c965 100644
--- a/Source/Core/VideoCommon/ShaderCache.h
+++ b/Source/Core/VideoCommon/ShaderCache.h
@@ -30,6 +30,7 @@
 #include "VideoCommon/VertexShaderGen.h"
 
 class NativeVertexFormat;
+enum class AbstractTextureFormat : u32;
 
 namespace VideoCommon
 {
@@ -129,6 +130,7 @@ private:
   // Configuration bits.
   APIType m_api_type = APIType::Nothing;
   ShaderHostConfig m_host_config = {};
+  AbstractTextureFormat m_efb_depth_format;
   u32 m_efb_multisamples = 1;
   std::unique_ptr<AsyncShaderCompiler> m_async_shader_compiler;
 
diff --git a/Source/Core/VideoCommon/TextureConfig.h b/Source/Core/VideoCommon/TextureConfig.h
index 1aa27cca4c..a2358ff3b0 100644
--- a/Source/Core/VideoCommon/TextureConfig.h
+++ b/Source/Core/VideoCommon/TextureConfig.h
@@ -20,6 +20,7 @@ enum class AbstractTextureFormat : u32
   BPTC,
   R16,
   D16,
+  D24_S8,
   R32F,
   D32F,
   D32F_S8,