diff --git a/Source/Core/Common/Debug/MemoryPatches.cpp b/Source/Core/Common/Debug/MemoryPatches.cpp
index 8dd9b5716d..f48e6e5bb5 100644
--- a/Source/Core/Common/Debug/MemoryPatches.cpp
+++ b/Source/Core/Common/Debug/MemoryPatches.cpp
@@ -38,6 +38,23 @@ void MemoryPatches::SetPatch(u32 address, std::vector<u8> value)
   Patch(index);
 }
 
+void MemoryPatches::SetFramePatch(u32 address, u32 value)
+{
+  const std::size_t index = m_patches.size();
+  m_patches.emplace_back(address, value);
+  m_patches.back().type = MemoryPatch::ApplyType::EachFrame;
+  Patch(index);
+}
+
+void MemoryPatches::SetFramePatch(u32 address, std::vector<u8> value)
+{
+  UnsetPatch(address);
+  const std::size_t index = m_patches.size();
+  m_patches.emplace_back(address, std::move(value));
+  m_patches.back().type = MemoryPatch::ApplyType::EachFrame;
+  Patch(index);
+}
+
 const std::vector<MemoryPatch>& MemoryPatches::GetPatches() const
 {
   return m_patches;
@@ -81,6 +98,7 @@ bool MemoryPatches::HasEnabledPatch(u32 address) const
 void MemoryPatches::RemovePatch(std::size_t index)
 {
   DisablePatch(index);
+  UnPatch(index);
   m_patches.erase(m_patches.begin() + index);
 }
 
@@ -88,7 +106,10 @@ void MemoryPatches::ClearPatches()
 {
   const std::size_t size = m_patches.size();
   for (std::size_t index = 0; index < size; ++index)
+  {
     DisablePatch(index);
+    UnPatch(index);
+  }
   m_patches.clear();
 }
 }  // namespace Common::Debug
diff --git a/Source/Core/Common/Debug/MemoryPatches.h b/Source/Core/Common/Debug/MemoryPatches.h
index abf88b0499..2a4f902dcd 100644
--- a/Source/Core/Common/Debug/MemoryPatches.h
+++ b/Source/Core/Common/Debug/MemoryPatches.h
@@ -19,12 +19,19 @@ struct MemoryPatch
     Disabled
   };
 
+  enum class ApplyType
+  {
+    Once,
+    EachFrame
+  };
+
   MemoryPatch(u32 address_, std::vector<u8> value_);
   MemoryPatch(u32 address_, u32 value_);
 
   u32 address;
   std::vector<u8> value;
   State is_enabled = State::Enabled;
+  ApplyType type = ApplyType::Once;
 };
 
 class MemoryPatches
@@ -35,6 +42,8 @@ public:
 
   void SetPatch(u32 address, u32 value);
   void SetPatch(u32 address, std::vector<u8> value);
+  void SetFramePatch(u32 address, u32 value);
+  void SetFramePatch(u32 address, std::vector<u8> value);
   const std::vector<MemoryPatch>& GetPatches() const;
   void UnsetPatch(u32 address);
   void EnablePatch(std::size_t index);
@@ -42,9 +51,11 @@ public:
   bool HasEnabledPatch(u32 address) const;
   void RemovePatch(std::size_t index);
   void ClearPatches();
+  virtual void ApplyExistingPatch(std::size_t index) = 0;
 
 protected:
   virtual void Patch(std::size_t index) = 0;
+  virtual void UnPatch(std::size_t index) = 0;
 
   std::vector<MemoryPatch> m_patches;
 };
diff --git a/Source/Core/Common/Debug/Watches.cpp b/Source/Core/Common/Debug/Watches.cpp
index 0088c8f26a..dddb3f3435 100644
--- a/Source/Core/Common/Debug/Watches.cpp
+++ b/Source/Core/Common/Debug/Watches.cpp
@@ -62,6 +62,11 @@ void Watches::UpdateWatchName(std::size_t index, std::string name)
   m_watches[index].name = std::move(name);
 }
 
+void Watches::UpdateWatchLockedState(std::size_t index, bool locked)
+{
+  m_watches[index].locked = locked;
+}
+
 void Watches::EnableWatch(std::size_t index)
 {
   m_watches[index].is_enabled = Watch::State::Enabled;
diff --git a/Source/Core/Common/Debug/Watches.h b/Source/Core/Common/Debug/Watches.h
index 9cb7e3e76d..fc16adb826 100644
--- a/Source/Core/Common/Debug/Watches.h
+++ b/Source/Core/Common/Debug/Watches.h
@@ -22,6 +22,7 @@ struct Watch
   u32 address;
   std::string name;
   State is_enabled;
+  bool locked = false;
 
   Watch(u32 address, std::string name, State is_enabled);
 };
@@ -36,6 +37,7 @@ public:
   void UpdateWatch(std::size_t index, u32 address, std::string name);
   void UpdateWatchAddress(std::size_t index, u32 address);
   void UpdateWatchName(std::size_t index, std::string name);
+  void UpdateWatchLockedState(std::size_t index, bool locked);
   void EnableWatch(std::size_t index);
   void DisableWatch(std::size_t index);
   bool HasEnabledWatch(u32 address) const;
diff --git a/Source/Core/Common/DebugInterface.h b/Source/Core/Common/DebugInterface.h
index a59ac79f69..17c10a1894 100644
--- a/Source/Core/Common/DebugInterface.h
+++ b/Source/Core/Common/DebugInterface.h
@@ -32,6 +32,7 @@ public:
   virtual void UpdateWatch(std::size_t index, u32 address, std::string name) = 0;
   virtual void UpdateWatchAddress(std::size_t index, u32 address) = 0;
   virtual void UpdateWatchName(std::size_t index, std::string name) = 0;
+  virtual void UpdateWatchLockedState(std::size_t index, bool locked) = 0;
   virtual void EnableWatch(std::size_t index) = 0;
   virtual void DisableWatch(std::size_t index) = 0;
   virtual bool HasEnabledWatch(u32 address) const = 0;
@@ -43,6 +44,8 @@ public:
   // Memory Patches
   virtual void SetPatch(u32 address, u32 value) = 0;
   virtual void SetPatch(u32 address, std::vector<u8> value) = 0;
+  virtual void SetFramePatch(u32 address, u32 value) = 0;
+  virtual void SetFramePatch(u32 address, std::vector<u8> value) = 0;
   virtual const std::vector<Debug::MemoryPatch>& GetPatches() const = 0;
   virtual void UnsetPatch(u32 address) = 0;
   virtual void EnablePatch(std::size_t index) = 0;
@@ -50,6 +53,7 @@ public:
   virtual bool HasEnabledPatch(u32 address) const = 0;
   virtual void RemovePatch(std::size_t index) = 0;
   virtual void ClearPatches() = 0;
+  virtual void ApplyExistingPatch(std::size_t index) = 0;
 
   // Threads
   virtual Debug::Threads GetThreads() const = 0;
diff --git a/Source/Core/Core/Debugger/PPCDebugInterface.cpp b/Source/Core/Core/Debugger/PPCDebugInterface.cpp
index 2cbeae41fb..75488237ab 100644
--- a/Source/Core/Core/Debugger/PPCDebugInterface.cpp
+++ b/Source/Core/Core/Debugger/PPCDebugInterface.cpp
@@ -19,13 +19,13 @@
 #include "Core/Core.h"
 #include "Core/Debugger/OSThread.h"
 #include "Core/HW/DSP.h"
+#include "Core/PatchEngine.h"
 #include "Core/PowerPC/MMU.h"
 #include "Core/PowerPC/PPCSymbolDB.h"
 #include "Core/PowerPC/PowerPC.h"
 
-void PPCPatches::Patch(std::size_t index)
+void ApplyMemoryPatch(Common::Debug::MemoryPatch& patch, bool store_existing_value)
 {
-  auto& patch = m_patches[index];
   if (patch.value.empty())
     return;
 
@@ -36,9 +36,16 @@ void PPCPatches::Patch(std::size_t index)
 
   for (u32 offset = 0; offset < size; ++offset)
   {
-    const u8 value = PowerPC::HostRead_U8(address + offset);
-    PowerPC::HostWrite_U8(patch.value[offset], address + offset);
-    patch.value[offset] = value;
+    if (store_existing_value)
+    {
+      const u8 value = PowerPC::HostRead_U8(address + offset);
+      PowerPC::HostWrite_U8(patch.value[offset], address + offset);
+      patch.value[offset] = value;
+    }
+    else
+    {
+      PowerPC::HostWrite_U8(patch.value[offset], address + offset);
+    }
 
     if (((address + offset) % 4) == 3)
       PowerPC::ScheduleInvalidateCacheThreadSafe(Common::AlignDown(address + offset, 4));
@@ -50,6 +57,30 @@ void PPCPatches::Patch(std::size_t index)
   }
 }
 
+void PPCPatches::ApplyExistingPatch(std::size_t index)
+{
+  auto& patch = m_patches[index];
+  ApplyMemoryPatch(patch, false);
+}
+
+void PPCPatches::Patch(std::size_t index)
+{
+  auto& patch = m_patches[index];
+  if (patch.type == Common::Debug::MemoryPatch::ApplyType::Once)
+    ApplyMemoryPatch(patch);
+  else
+    PatchEngine::AddMemoryPatch(index);
+}
+
+void PPCPatches::UnPatch(std::size_t index)
+{
+  auto& patch = m_patches[index];
+  if (patch.type == Common::Debug::MemoryPatch::ApplyType::Once)
+    return;
+
+  PatchEngine::RemoveMemoryPatch(index);
+}
+
 PPCDebugInterface::PPCDebugInterface() = default;
 PPCDebugInterface::~PPCDebugInterface() = default;
 
@@ -88,6 +119,11 @@ void PPCDebugInterface::UpdateWatchName(std::size_t index, std::string name)
   return m_watches.UpdateWatchName(index, std::move(name));
 }
 
+void PPCDebugInterface::UpdateWatchLockedState(std::size_t index, bool locked)
+{
+  return m_watches.UpdateWatchLockedState(index, locked);
+}
+
 void PPCDebugInterface::EnableWatch(std::size_t index)
 {
   m_watches.EnableWatch(index);
@@ -133,6 +169,16 @@ void PPCDebugInterface::SetPatch(u32 address, std::vector<u8> value)
   m_patches.SetPatch(address, std::move(value));
 }
 
+void PPCDebugInterface::SetFramePatch(u32 address, u32 value)
+{
+  m_patches.SetFramePatch(address, value);
+}
+
+void PPCDebugInterface::SetFramePatch(u32 address, std::vector<u8> value)
+{
+  m_patches.SetFramePatch(address, std::move(value));
+}
+
 const std::vector<Common::Debug::MemoryPatch>& PPCDebugInterface::GetPatches() const
 {
   return m_patches.GetPatches();
@@ -168,6 +214,11 @@ void PPCDebugInterface::ClearPatches()
   m_patches.ClearPatches();
 }
 
+void PPCDebugInterface::ApplyExistingPatch(std::size_t index)
+{
+  m_patches.ApplyExistingPatch(index);
+}
+
 Common::Debug::Threads PPCDebugInterface::GetThreads() const
 {
   Common::Debug::Threads threads;
diff --git a/Source/Core/Core/Debugger/PPCDebugInterface.h b/Source/Core/Core/Debugger/PPCDebugInterface.h
index 4c5dfb0fec..4d44481a8b 100644
--- a/Source/Core/Core/Debugger/PPCDebugInterface.h
+++ b/Source/Core/Core/Debugger/PPCDebugInterface.h
@@ -12,10 +12,16 @@
 #include "Common/DebugInterface.h"
 #include "Core/NetworkCaptureLogger.h"
 
-class PPCPatches : public Common::Debug::MemoryPatches
+void ApplyMemoryPatch(Common::Debug::MemoryPatch& patch, bool store_existing_value = true);
+
+class PPCPatches final : public Common::Debug::MemoryPatches
 {
+public:
+  void ApplyExistingPatch(std::size_t index) override;
+
 private:
   void Patch(std::size_t index) override;
+  void UnPatch(std::size_t index) override;
 };
 
 // wrapper between disasm control and Dolphin debugger
@@ -34,6 +40,7 @@ public:
   void UpdateWatch(std::size_t index, u32 address, std::string name) override;
   void UpdateWatchAddress(std::size_t index, u32 address) override;
   void UpdateWatchName(std::size_t index, std::string name) override;
+  void UpdateWatchLockedState(std::size_t index, bool locked) override;
   void EnableWatch(std::size_t index) override;
   void DisableWatch(std::size_t index) override;
   bool HasEnabledWatch(u32 address) const override;
@@ -45,6 +52,8 @@ public:
   // Memory Patches
   void SetPatch(u32 address, u32 value) override;
   void SetPatch(u32 address, std::vector<u8> value) override;
+  void SetFramePatch(u32 address, u32 value) override;
+  void SetFramePatch(u32 address, std::vector<u8> value) override;
   const std::vector<Common::Debug::MemoryPatch>& GetPatches() const override;
   void UnsetPatch(u32 address) override;
   void EnablePatch(std::size_t index) override;
@@ -52,6 +61,7 @@ public:
   bool HasEnabledPatch(u32 address) const override;
   void RemovePatch(std::size_t index) override;
   void ClearPatches() override;
+  void ApplyExistingPatch(std::size_t index) override;
 
   // Threads
   Common::Debug::Threads GetThreads() const override;
diff --git a/Source/Core/Core/PatchEngine.cpp b/Source/Core/Core/PatchEngine.cpp
index f5fe19b7ef..a525e67261 100644
--- a/Source/Core/Core/PatchEngine.cpp
+++ b/Source/Core/Core/PatchEngine.cpp
@@ -11,13 +11,16 @@
 #include <array>
 #include <iterator>
 #include <map>
+#include <mutex>
 #include <optional>
+#include <span>
 #include <string>
 #include <vector>
 
 #include <fmt/format.h>
 
 #include "Common/Assert.h"
+#include "Common/Debug/MemoryPatches.h"
 #include "Common/IniFile.h"
 #include "Common/StringUtil.h"
 
@@ -25,6 +28,7 @@
 #include "Core/CheatCodes.h"
 #include "Core/Config/SessionSettings.h"
 #include "Core/ConfigManager.h"
+#include "Core/Debugger/PPCDebugInterface.h"
 #include "Core/GeckoCode.h"
 #include "Core/GeckoCodeConfig.h"
 #include "Core/PowerPC/MMU.h"
@@ -39,6 +43,8 @@ constexpr std::array<const char*, 3> s_patch_type_strings{{
 }};
 
 static std::vector<Patch> s_on_frame;
+static std::vector<std::size_t> s_on_frame_memory;
+static std::mutex s_on_frame_memory_mutex;
 static std::map<u32, int> s_speed_hacks;
 
 const char* PatchTypeAsString(PatchType type)
@@ -257,6 +263,15 @@ static void ApplyPatches(const std::vector<Patch>& patches)
   }
 }
 
+static void ApplyMemoryPatches(std::span<const std::size_t> memory_patch_indices)
+{
+  std::lock_guard lock(s_on_frame_memory_mutex);
+  for (std::size_t index : memory_patch_indices)
+  {
+    PowerPC::debug_interface.ApplyExistingPatch(index);
+  }
+}
+
 // Requires MSR.DR, MSR.IR
 // There's no perfect way to do this, it's just a heuristic.
 // We require at least 2 stack frames, if the stack is shallower than that then it won't work.
@@ -281,6 +296,19 @@ static bool IsStackSane()
          0 != PowerPC::HostRead_Instruction(address);
 }
 
+void AddMemoryPatch(std::size_t index)
+{
+  std::lock_guard lock(s_on_frame_memory_mutex);
+  s_on_frame_memory.push_back(index);
+}
+
+void RemoveMemoryPatch(std::size_t index)
+{
+  std::lock_guard lock(s_on_frame_memory_mutex);
+  s_on_frame_memory.erase(std::remove(s_on_frame_memory.begin(), s_on_frame_memory.end(), index),
+                          s_on_frame_memory.end());
+}
+
 bool ApplyFramePatches()
 {
   // Because we're using the VI Interrupt to time this instead of patching the game with a
@@ -297,6 +325,7 @@ bool ApplyFramePatches()
   }
 
   ApplyPatches(s_on_frame);
+  ApplyMemoryPatches(s_on_frame_memory);
 
   // Run the Gecko code handler
   Gecko::RunCodeHandler();
diff --git a/Source/Core/Core/PatchEngine.h b/Source/Core/Core/PatchEngine.h
index 9c0a7ed9ee..4218e65fcb 100644
--- a/Source/Core/Core/PatchEngine.h
+++ b/Source/Core/Core/PatchEngine.h
@@ -51,6 +51,9 @@ void LoadPatchSection(const std::string& section, std::vector<Patch>* patches,
 void SavePatchSection(IniFile* local_ini, const std::vector<Patch>& patches);
 void LoadPatches();
 
+void AddMemoryPatch(std::size_t index);
+void RemoveMemoryPatch(std::size_t index);
+
 bool ApplyFramePatches();
 void Shutdown();
 void Reload();
diff --git a/Source/Core/Core/PowerPC/PowerPC.cpp b/Source/Core/Core/PowerPC/PowerPC.cpp
index 411705d833..5110788645 100644
--- a/Source/Core/Core/PowerPC/PowerPC.cpp
+++ b/Source/Core/Core/PowerPC/PowerPC.cpp
@@ -298,7 +298,7 @@ void Reset()
 
 void ScheduleInvalidateCacheThreadSafe(u32 address)
 {
-  if (CPU::GetState() == CPU::State::Running)
+  if (CPU::GetState() == CPU::State::Running && !Core::IsCPUThread())
   {
     Core::System::GetInstance().GetCoreTiming().ScheduleEvent(
         0, s_invalidate_cache_thread_safe, address, CoreTiming::FromThread::NON_CPU);
diff --git a/Source/Core/DolphinQt/CheatSearchWidget.cpp b/Source/Core/DolphinQt/CheatSearchWidget.cpp
index 33594f7d1d..e4e81b3820 100644
--- a/Source/Core/DolphinQt/CheatSearchWidget.cpp
+++ b/Source/Core/DolphinQt/CheatSearchWidget.cpp
@@ -454,6 +454,10 @@ void CheatSearchWidget::OnAddressTableContextMenu()
   QMenu* menu = new QMenu(this);
 
   menu->addAction(tr("Show in memory"), [this, address] { emit ShowMemory(address); });
+  menu->addAction(tr("Add to watch"), this, [this, address] {
+    const QString name = QStringLiteral("mem_%1").arg(address, 8, 16, QLatin1Char('0'));
+    emit RequestWatch(name, address);
+  });
   menu->addAction(tr("Generate Action Replay Code"), this, &CheatSearchWidget::GenerateARCode);
 
   menu->exec(QCursor::pos());
diff --git a/Source/Core/DolphinQt/CheatSearchWidget.h b/Source/Core/DolphinQt/CheatSearchWidget.h
index 88aeeb9fcb..e885f7a181 100644
--- a/Source/Core/DolphinQt/CheatSearchWidget.h
+++ b/Source/Core/DolphinQt/CheatSearchWidget.h
@@ -41,6 +41,7 @@ public:
 
 signals:
   void ActionReplayCodeGenerated(const ActionReplay::ARCode& ar_code);
+  void RequestWatch(QString name, u32 address);
   void ShowMemory(const u32 address);
 
 private:
diff --git a/Source/Core/DolphinQt/CheatsManager.cpp b/Source/Core/DolphinQt/CheatsManager.cpp
index f4b7154b6f..743126f574 100644
--- a/Source/Core/DolphinQt/CheatsManager.cpp
+++ b/Source/Core/DolphinQt/CheatsManager.cpp
@@ -123,6 +123,8 @@ void CheatsManager::OnNewSessionCreated(const Cheats::CheatSearchSessionBase& se
                  m_ar_code->AddCode(ar_code);
              });
   w->connect(w, &CheatSearchWidget::ShowMemory, [this](u32 address) { emit ShowMemory(address); });
+  w->connect(w, &CheatSearchWidget::RequestWatch,
+             [this](QString name, u32 address) { emit RequestWatch(name, address); });
   m_tab_widget->setCurrentIndex(tab_index);
 }
 
diff --git a/Source/Core/DolphinQt/CheatsManager.h b/Source/Core/DolphinQt/CheatsManager.h
index 8cd478e81c..5e7ddb8bb2 100644
--- a/Source/Core/DolphinQt/CheatsManager.h
+++ b/Source/Core/DolphinQt/CheatsManager.h
@@ -36,6 +36,7 @@ public:
 signals:
   void OpenGeneralSettings();
   void ShowMemory(u32 address);
+  void RequestWatch(QString name, u32 address);
 
 private:
   void CreateWidgets();
diff --git a/Source/Core/DolphinQt/Debugger/WatchWidget.cpp b/Source/Core/DolphinQt/Debugger/WatchWidget.cpp
index e0573f39d4..2f4ea27598 100644
--- a/Source/Core/DolphinQt/Debugger/WatchWidget.cpp
+++ b/Source/Core/DolphinQt/Debugger/WatchWidget.cpp
@@ -83,7 +83,8 @@ void WatchWidget::CreateWidgets()
   m_table->setColumnCount(NUM_COLUMNS);
   m_table->verticalHeader()->setHidden(true);
   m_table->setContextMenuPolicy(Qt::CustomContextMenu);
-  m_table->setSelectionMode(QAbstractItemView::SingleSelection);
+  m_table->setSelectionMode(QAbstractItemView::ExtendedSelection);
+  m_table->setSelectionBehavior(QAbstractItemView::SelectRows);
 
   m_new = m_toolbar->addAction(tr("New"), this, &WatchWidget::OnNewWatch);
   m_delete = m_toolbar->addAction(tr("Delete"), this, &WatchWidget::OnDelete);
@@ -158,11 +159,11 @@ void WatchWidget::Update()
        // i18n: Data type used in computing
        tr("String"),
        // i18n: Floating-point (non-integer) number
-       tr("Float")});
+       tr("Float"), tr("Locked")});
 
   for (int i = 0; i < size; i++)
   {
-    auto entry = PowerPC::debug_interface.GetWatch(i);
+    const auto& entry = PowerPC::debug_interface.GetWatch(i);
 
     auto* label = new QTableWidgetItem(QString::fromStdString(entry.name));
     auto* address =
@@ -172,8 +173,11 @@ void WatchWidget::Update()
     auto* string = new QTableWidgetItem;
     auto* floatValue = new QTableWidgetItem;
 
-    std::array<QTableWidgetItem*, NUM_COLUMNS> items = {label,   address, hex,
-                                                        decimal, string,  floatValue};
+    auto* lockValue = new QTableWidgetItem;
+    lockValue->setFlags(Qt::ItemIsEnabled | Qt::ItemIsSelectable | Qt::ItemIsUserCheckable);
+
+    std::array<QTableWidgetItem*, NUM_COLUMNS> items = {label,  address,    hex,      decimal,
+                                                        string, floatValue, lockValue};
 
     QBrush brush = QPalette().brush(QPalette::Text);
 
@@ -189,6 +193,7 @@ void WatchWidget::Update()
         decimal->setText(QString::number(PowerPC::HostRead_U32(entry.address)));
         string->setText(QString::fromStdString(PowerPC::HostGetString(entry.address, 32)));
         floatValue->setText(QString::number(PowerPC::HostRead_F32(entry.address)));
+        lockValue->setCheckState(entry.locked ? Qt::Checked : Qt::Unchecked);
       }
     }
 
@@ -235,11 +240,7 @@ void WatchWidget::OnDelete()
   if (m_table->selectedItems().empty())
     return;
 
-  auto row_variant = m_table->selectedItems()[0]->data(Qt::UserRole);
-  if (row_variant.isNull())
-    return;
-
-  DeleteWatch(row_variant.toInt());
+  DeleteSelectedWatches();
 }
 
 void WatchWidget::OnClear()
@@ -280,6 +281,10 @@ void WatchWidget::OnLoad()
 
   if (ini.GetLines("Watches", &watches, false))
   {
+    for (const auto& watch : PowerPC::debug_interface.GetWatches())
+    {
+      PowerPC::debug_interface.UnsetPatch(watch.address);
+    }
     PowerPC::debug_interface.ClearWatches();
     PowerPC::debug_interface.LoadWatchesFromStrings(watches);
   }
@@ -302,20 +307,30 @@ void WatchWidget::ShowContextMenu()
 
   if (!m_table->selectedItems().empty())
   {
-    auto row_variant = m_table->selectedItems()[0]->data(Qt::UserRole);
-
-    if (!row_variant.isNull())
+    const std::size_t count = m_table->selectionModel()->selectedRows().count();
+    if (count > 1)
     {
-      int row = row_variant.toInt();
+      menu->addAction(tr("&Delete Watches"), this, [this] { DeleteSelectedWatches(); });
+      menu->addAction(tr("&Lock Watches"), this, [this] { LockSelectedWatches(); });
+      menu->addAction(tr("&Unlock Watches"), this, [this] { UnlockSelectedWatches(); });
+    }
+    else if (count == 1)
+    {
+      auto row_variant = m_table->selectedItems()[0]->data(Qt::UserRole);
 
-      if (row >= 0)
+      if (!row_variant.isNull())
       {
-        menu->addAction(tr("Show in Memory"), this, [this, row] { ShowInMemory(row); });
-        // i18n: This kind of "watch" is used for watching emulated memory.
-        // It's not related to timekeeping devices.
-        menu->addAction(tr("&Delete Watch"), this, [this, row] { DeleteWatch(row); });
-        menu->addAction(tr("&Add Memory Breakpoint"), this,
-                        [this, row] { AddWatchBreakpoint(row); });
+        int row = row_variant.toInt();
+
+        if (row >= 0)
+        {
+          menu->addAction(tr("Show in Memory"), this, [this, row] { ShowInMemory(row); });
+          // i18n: This kind of "watch" is used for watching emulated memory.
+          // It's not related to timekeeping devices.
+          menu->addAction(tr("&Delete Watch"), this, [this, row] { DeleteWatchAndUpdate(row); });
+          menu->addAction(tr("&Add Memory Breakpoint"), this,
+                          [this, row] { AddWatchBreakpoint(row); });
+        }
       }
     }
   }
@@ -349,29 +364,35 @@ void WatchWidget::OnItemChanged(QTableWidgetItem* item)
   {
     switch (column)
     {
-    // Label
-    case 0:
+    case COLUMN_INDEX_LABEL:
       if (item->text().isEmpty())
-        DeleteWatch(row);
+        DeleteWatchAndUpdate(row);
       else
         PowerPC::debug_interface.UpdateWatchName(row, item->text().toStdString());
       break;
-    // Address
-    // Hexadecimal
-    // Decimal
-    case 1:
-    case 2:
-    case 3:
+    case COLUMN_INDEX_ADDRESS:
+    case COLUMN_INDEX_HEX:
+    case COLUMN_INDEX_DECIMAL:
     {
       bool good;
-      quint32 value = item->text().toUInt(&good, column < 3 ? 16 : 10);
+      const bool column_uses_hex_formatting =
+          column == COLUMN_INDEX_ADDRESS || column == COLUMN_INDEX_HEX;
+      quint32 value = item->text().toUInt(&good, column_uses_hex_formatting ? 16 : 10);
 
       if (good)
       {
-        if (column == 1)
+        if (column == COLUMN_INDEX_ADDRESS)
+        {
+          const auto& watch = PowerPC::debug_interface.GetWatch(row);
+          PowerPC::debug_interface.UnsetPatch(watch.address);
           PowerPC::debug_interface.UpdateWatchAddress(row, value);
+          if (watch.locked)
+            LockWatchAddress(value);
+        }
         else
+        {
           PowerPC::HostWrite_U32(value, PowerPC::debug_interface.GetWatch(row).address);
+        }
       }
       else
       {
@@ -379,15 +400,68 @@ void WatchWidget::OnItemChanged(QTableWidgetItem* item)
       }
       break;
     }
+    case COLUMN_INDEX_LOCK:
+    {
+      PowerPC::debug_interface.UpdateWatchLockedState(row, item->checkState() == Qt::Checked);
+      const auto& watch = PowerPC::debug_interface.GetWatch(row);
+      if (watch.locked)
+        LockWatchAddress(watch.address);
+      else
+        PowerPC::debug_interface.UnsetPatch(watch.address);
+      break;
+    }
     }
 
     Update();
   }
 }
 
+void WatchWidget::LockWatchAddress(u32 address)
+{
+  const std::string memory_data_as_string = PowerPC::HostGetString(address, 4);
+
+  std::vector<u8> bytes;
+  for (const char c : memory_data_as_string)
+  {
+    bytes.push_back(static_cast<u8>(c));
+  }
+
+  PowerPC::debug_interface.SetFramePatch(address, bytes);
+}
+
+void WatchWidget::DeleteSelectedWatches()
+{
+  std::vector<int> row_indices;
+  for (const auto& index : m_table->selectionModel()->selectedRows())
+  {
+    const auto* item = m_table->item(index.row(), index.column());
+    const auto row_variant = item->data(Qt::UserRole);
+    if (row_variant.isNull())
+      continue;
+
+    row_indices.push_back(row_variant.toInt());
+  }
+
+  // Sort greatest to smallest, so we
+  // don't stomp on existing indices
+  std::sort(row_indices.begin(), row_indices.end(), std::greater{});
+  for (const int row : row_indices)
+  {
+    DeleteWatch(row);
+  }
+
+  Update();
+}
+
 void WatchWidget::DeleteWatch(int row)
 {
+  PowerPC::debug_interface.UnsetPatch(PowerPC::debug_interface.GetWatch(row).address);
   PowerPC::debug_interface.RemoveWatch(row);
+}
+
+void WatchWidget::DeleteWatchAndUpdate(int row)
+{
+  DeleteWatch(row);
   Update();
 }
 
@@ -406,3 +480,41 @@ void WatchWidget::AddWatch(QString name, u32 addr)
   PowerPC::debug_interface.SetWatch(addr, name.toStdString());
   Update();
 }
+
+void WatchWidget::LockSelectedWatches()
+{
+  for (const auto& index : m_table->selectionModel()->selectedRows())
+  {
+    const auto* item = m_table->item(index.row(), index.column());
+    const auto row_variant = item->data(Qt::UserRole);
+    if (row_variant.isNull())
+      continue;
+    const int row = row_variant.toInt();
+    const auto& watch = PowerPC::debug_interface.GetWatch(row);
+    if (watch.locked)
+      continue;
+    PowerPC::debug_interface.UpdateWatchLockedState(row, true);
+    LockWatchAddress(watch.address);
+  }
+
+  Update();
+}
+
+void WatchWidget::UnlockSelectedWatches()
+{
+  for (const auto& index : m_table->selectionModel()->selectedRows())
+  {
+    const auto* item = m_table->item(index.row(), index.column());
+    const auto row_variant = item->data(Qt::UserRole);
+    if (row_variant.isNull())
+      continue;
+    const int row = row_variant.toInt();
+    const auto& watch = PowerPC::debug_interface.GetWatch(row);
+    if (!watch.locked)
+      continue;
+    PowerPC::debug_interface.UpdateWatchLockedState(row, false);
+    PowerPC::debug_interface.UnsetPatch(watch.address);
+  }
+
+  Update();
+}
diff --git a/Source/Core/DolphinQt/Debugger/WatchWidget.h b/Source/Core/DolphinQt/Debugger/WatchWidget.h
index 6529bba4d3..22aefb9b0e 100644
--- a/Source/Core/DolphinQt/Debugger/WatchWidget.h
+++ b/Source/Core/DolphinQt/Debugger/WatchWidget.h
@@ -46,10 +46,15 @@ private:
 
   void ShowContextMenu();
   void OnItemChanged(QTableWidgetItem* item);
+  void LockWatchAddress(u32 address);
+  void DeleteSelectedWatches();
   void DeleteWatch(int row);
+  void DeleteWatchAndUpdate(int row);
   void AddWatchBreakpoint(int row);
   void ShowInMemory(int row);
   void UpdateIcons();
+  void LockSelectedWatches();
+  void UnlockSelectedWatches();
 
   QAction* m_new;
   QAction* m_delete;
@@ -61,5 +66,12 @@ private:
 
   bool m_updating = false;
 
-  static constexpr int NUM_COLUMNS = 6;
+  static constexpr int NUM_COLUMNS = 7;
+  static constexpr int COLUMN_INDEX_LABEL = 0;
+  static constexpr int COLUMN_INDEX_ADDRESS = 1;
+  static constexpr int COLUMN_INDEX_HEX = 2;
+  static constexpr int COLUMN_INDEX_DECIMAL = 3;
+  static constexpr int COLUMN_INDEX_STRING = 4;
+  static constexpr int COLUMN_INDEX_FLOAT = 5;
+  static constexpr int COLUMN_INDEX_LOCK = 6;
 };
diff --git a/Source/Core/DolphinQt/MainWindow.cpp b/Source/Core/DolphinQt/MainWindow.cpp
index 5c13da946c..210dc895c4 100644
--- a/Source/Core/DolphinQt/MainWindow.cpp
+++ b/Source/Core/DolphinQt/MainWindow.cpp
@@ -467,6 +467,7 @@ void MainWindow::CreateComponents()
   connect(m_breakpoint_widget, &BreakpointWidget::ShowMemory, m_memory_widget,
           &MemoryWidget::SetAddress);
   connect(m_cheats_manager, &CheatsManager::ShowMemory, m_memory_widget, &MemoryWidget::SetAddress);
+  connect(m_cheats_manager, &CheatsManager::RequestWatch, request_watch);
 }
 
 void MainWindow::ConnectMenuBar()