diff --git a/CMakeLists.txt b/CMakeLists.txt
index fb37788513..8da581bcf6 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -504,14 +504,14 @@ if (OPENGL_GL)
 endif()
 
 if(ENABLE_X11)
-  find_package(X11)
+  pkg_check_modules(X11 x11 IMPORTED_TARGET)
   if(X11_FOUND)
     add_definitions(-DHAVE_X11=1)
-    check_lib(XRANDR xrandr Xrandr)
+    pkg_check_modules(XRANDR xrandr IMPORTED_TARGET)
     if(XRANDR_FOUND)
       add_definitions(-DHAVE_XRANDR=1)
     endif()
-    pkg_check_modules(X11_INPUT REQUIRED xi>=1.5.0)
+    pkg_check_modules(X11_INPUT REQUIRED xi>=1.5.0 IMPORTED_TARGET)
     message(STATUS "X11 support enabled")
   else()
     message(WARNING "X11 support enabled but not found. This build will not support X11.")
@@ -802,15 +802,16 @@ include_directories("${PROJECT_BINARY_DIR}/Source/Core")
 # Unit testing.
 #
 if(ENABLE_TESTS)
-  find_package(GTest)
-  if (GTEST_FOUND)
-    message(STATUS "Using the system gtest")
-    include_directories(${GTEST_INCLUDE_DIRS})
-  else()
-    message(STATUS "Using static gtest from Externals")
-    add_subdirectory(Externals/gtest EXCLUDE_FROM_ALL)
+  dolphin_find_optional_system_library_pkgconfig(GTEST
+    gtest gtest::gtest Externals/gtest
+  )
+  # dolphin_find_optional_system_library_pkgconfig() doesn't add an alias if it
+  # uses the bundled libraries, so we add one ourselves.
+  if (NOT TARGET gtest::gtest)
+    add_library(gtest::gtest ALIAS gtest)
   endif()
-  # Force gtest to link the C runtime dynamically on Windows in order to avoid runtime mismatches.
+  # Force gtest to link the C runtime dynamically on Windows in order to avoid
+  # runtime mismatches.
   set(gtest_force_shared_crt ON CACHE BOOL "" FORCE)
 else()
   message(STATUS "Unit tests are disabled")
diff --git a/Source/Core/Core/CMakeLists.txt b/Source/Core/Core/CMakeLists.txt
index 9d477b50a5..535e687475 100644
--- a/Source/Core/Core/CMakeLists.txt
+++ b/Source/Core/Core/CMakeLists.txt
@@ -751,6 +751,12 @@ if(CMAKE_SYSTEM_NAME MATCHES "Linux")
   endif()
 endif()
 
+if(CMAKE_SYSTEM_NAME MATCHES "OpenBSD")
+  # OpenBSD doesn't allow memory to be both writable and executable by default.
+  # The JIT currently needs this.
+  target_link_options(core PUBLIC -Wl,-zwxneeded)
+endif()
+
 if(TARGET Hidapi::Hidapi)
   target_sources(core PRIVATE
     HW/WiimoteReal/IOhidapi.cpp
diff --git a/Source/Core/Core/HW/WiimoteReal/IOhidapi.cpp b/Source/Core/Core/HW/WiimoteReal/IOhidapi.cpp
index ca0c2c5483..f10b2442fc 100644
--- a/Source/Core/Core/HW/WiimoteReal/IOhidapi.cpp
+++ b/Source/Core/Core/HW/WiimoteReal/IOhidapi.cpp
@@ -41,6 +41,13 @@ namespace WiimoteReal
 {
 WiimoteScannerHidapi::WiimoteScannerHidapi()
 {
+#ifdef __OpenBSD__
+  // OpenBSD renamed libhidapi's hidapi_init function because the system has its own USB library
+  // which contains a symbol with the same name. See:
+  // https://cvsweb.openbsd.org/ports/comms/libhidapi/patches/patch-hidapi_hidapi_h?rev=1.3&content-type=text/x-cvsweb-markup
+  // https://man.openbsd.org/usbhid.3
+#define hid_init hidapi_hid_init
+#endif
   int ret = hid_init();
   ASSERT_MSG(WIIMOTE, ret == 0, "Couldn't initialise hidapi.");
 }
diff --git a/Source/Core/DolphinNoGUI/CMakeLists.txt b/Source/Core/DolphinNoGUI/CMakeLists.txt
index 820f01c275..4f10169af1 100644
--- a/Source/Core/DolphinNoGUI/CMakeLists.txt
+++ b/Source/Core/DolphinNoGUI/CMakeLists.txt
@@ -5,8 +5,9 @@ add_executable(dolphin-nogui
   MainNoGUI.cpp
 )
 
-if(ENABLE_X11 AND X11_FOUND)
+if(X11_FOUND)
   target_sources(dolphin-nogui PRIVATE PlatformX11.cpp)
+  target_link_libraries(dolphin-nogui PRIVATE PkgConfig::XRANDR PkgConfig::X11)
 endif()
 
 if(WIN32)
diff --git a/Source/Core/InputCommon/CMakeLists.txt b/Source/Core/InputCommon/CMakeLists.txt
index 90b31e373a..ee144e32f4 100644
--- a/Source/Core/InputCommon/CMakeLists.txt
+++ b/Source/Core/InputCommon/CMakeLists.txt
@@ -125,14 +125,12 @@ elseif(APPLE)
     -fobjc-arc
   )
 elseif(X11_FOUND)
+  target_include_directories(inputcommon PUBLIC ${X11_INPUT_INCLUDE_DIRS})
   target_sources(inputcommon PRIVATE
     ControllerInterface/Xlib/XInput2.cpp
     ControllerInterface/Xlib/XInput2.h
   )
-  target_link_libraries(inputcommon PUBLIC
-    ${X11_LIBRARIES}
-    ${X11_INPUT_LIBRARIES}
-  )
+  target_link_libraries(inputcommon PRIVATE PkgConfig::X11_INPUT)
 elseif(ANDROID)
   target_compile_definitions(inputcommon PRIVATE -DCIFACE_USE_ANDROID)
   target_sources(inputcommon PRIVATE
diff --git a/Source/Core/UICommon/CMakeLists.txt b/Source/Core/UICommon/CMakeLists.txt
index 22e01d8d76..87dff079b5 100644
--- a/Source/Core/UICommon/CMakeLists.txt
+++ b/Source/Core/UICommon/CMakeLists.txt
@@ -42,10 +42,9 @@ if ((DEFINED CMAKE_ANDROID_ARCH_ABI AND CMAKE_ANDROID_ARCH_ABI MATCHES "x86|x86_
   target_link_libraries(uicommon PRIVATE bdisasm)
 endif()
 
-if(ENABLE_X11 AND X11_FOUND)
-  target_include_directories(uicommon PRIVATE ${X11_INCLUDE_DIR})
+if(X11_FOUND)
   target_sources(uicommon PRIVATE X11Utils.cpp)
-  target_link_libraries(uicommon PUBLIC ${XRANDR_LIBRARIES})
+  target_link_libraries(uicommon PUBLIC PkgConfig::XRANDR PkgConfig::X11)
 endif()
 
 if(TARGET LibUSB::LibUSB)
@@ -56,8 +55,24 @@ if(ENABLE_LLVM)
   find_package(LLVM CONFIG QUIET)
   if(LLVM_FOUND AND TARGET LLVM)
     message(STATUS "LLVM found, enabling LLVM support in disassembler")
-    target_compile_definitions(uicommon PRIVATE HAVE_LLVM)
-    target_link_libraries(uicommon PRIVATE LLVM)
+    # Minimal documentation about LLVM's CMake functions is available here:
+    # https://releases.llvm.org/16.0.0/docs/CMake.html#embedding-llvm-in-your-project
+    #
+    # However, you have to read the source code in any case.
+    # Look for LLVM-Config.cmake in your (Unix) system:
+    # $ find /usr -name LLVM-Config\\.cmake 2>/dev/null
+    separate_arguments(LLVM_DEFINITIONS_LIST NATIVE_COMMAND ${LLVM_DEFINITIONS})
+    target_compile_definitions(uicommon
+      PRIVATE HAVE_LLVM ${LLVM_DEFINITIONS_LIST}
+    )
+    target_link_directories(uicommon PRIVATE ${LLVM_LIBRARY_DIRS})
+    llvm_expand_pseudo_components(LLVM_EXPAND_COMPONENTS
+      AllTargetsInfos AllTargetsDisassemblers AllTargetsCodeGens
+    )
+    llvm_map_components_to_libnames(LLVM_LIBRARIES
+      mcdisassembler target ${LLVM_EXPAND_COMPONENTS}
+    )
+    target_link_libraries(uicommon PRIVATE ${LLVM_LIBRARIES})
     target_include_directories(uicommon PRIVATE ${LLVM_INCLUDE_DIRS})
   endif()
 endif()
diff --git a/Source/Core/VideoBackends/OGL/CMakeLists.txt b/Source/Core/VideoBackends/OGL/CMakeLists.txt
index 8fb8524054..30c4f98ba2 100644
--- a/Source/Core/VideoBackends/OGL/CMakeLists.txt
+++ b/Source/Core/VideoBackends/OGL/CMakeLists.txt
@@ -27,14 +27,10 @@ add_library(videoogl
   VideoBackend.h
 )
 
-target_link_libraries(videoogl
-PUBLIC
-  common
-  videocommon
-
-PRIVATE
-  ${X11_LIBRARIES}
-)
+target_link_libraries(videoogl PUBLIC common videocommon)
+if(X11_FOUND)
+  target_link_libraries(videoogl PRIVATE PkgConfig::X11)
+endif()
 
 if(MSVC)
   # Add precompiled header
diff --git a/Source/UnitTests/CMakeLists.txt b/Source/UnitTests/CMakeLists.txt
index 10dc4f397c..c5f1b966d1 100644
--- a/Source/UnitTests/CMakeLists.txt
+++ b/Source/UnitTests/CMakeLists.txt
@@ -5,7 +5,8 @@ add_custom_command(TARGET unittests POST_BUILD COMMAND ${CMAKE_CTEST_COMMAND} "-
 string(APPEND CMAKE_RUNTIME_OUTPUT_DIRECTORY "/Tests")
 
 add_library(unittests_main OBJECT UnitTestsMain.cpp)
-target_link_libraries(unittests_main PUBLIC fmt::fmt gtest)
+
+target_link_libraries(unittests_main PUBLIC fmt::fmt gtest::gtest)
 # Since this is a Core dependency, it can't be linked as a normal library.
 # Otherwise CMake inserts the library after core, but before other core
 # dependencies like videocommon which also use Host_ functions, which makes the