diff --git a/Source/Core/Core/PowerPC/PowerPC.cpp b/Source/Core/Core/PowerPC/PowerPC.cpp
index 172ce0c36c..68b21ab0e0 100644
--- a/Source/Core/Core/PowerPC/PowerPC.cpp
+++ b/Source/Core/Core/PowerPC/PowerPC.cpp
@@ -10,6 +10,7 @@
 #include "Common/MathUtil.h"
 
 #include "Core/ConfigManager.h"
+#include "Core/CoreTiming.h"
 #include "Core/HW/CPU.h"
 #include "Core/HW/Memmap.h"
 #include "Core/HW/SystemTimers.h"
@@ -35,6 +36,12 @@ BreakPoints breakpoints;
 MemChecks memchecks;
 PPCDebugInterface debug_interface;
 
+static int s_invalidate_cache_thread_safe;
+static void InvalidateCacheThreadSafe(u64 userdata, s64 cyclesLate)
+{
+  ppcState.iCache.Invalidate(static_cast<u32>(userdata));
+}
+
 u32 CompactCR()
 {
   u32 new_cr = 0;
@@ -117,6 +124,9 @@ void Init(int cpu_core)
   //   Changing the rounding mode has a limited effect.
   FPURoundMode::SetPrecisionMode(FPURoundMode::PREC_53);
 
+  s_invalidate_cache_thread_safe =
+      CoreTiming::RegisterEvent("invalidateEmulatedCache", InvalidateCacheThreadSafe);
+
   memset(ppcState.sr, 0, sizeof(ppcState.sr));
   ppcState.pagetable_base = 0;
   ppcState.pagetable_hashmask = 0;
@@ -173,6 +183,15 @@ void Init(int cpu_core)
     breakpoints.ClearAllTemporary();
 }
 
+void ScheduleInvalidateCacheThreadSafe(u32 address)
+{
+  if (CPU::GetState() == CPU::State::CPU_RUNNING)
+    CoreTiming::ScheduleEvent(0, s_invalidate_cache_thread_safe, address,
+                              CoreTiming::FromThread::NON_CPU);
+  else
+    PowerPC::ppcState.iCache.Invalidate(static_cast<u32>(address));
+}
+
 void Shutdown()
 {
   InjectExternalCPUCore(nullptr);
diff --git a/Source/Core/Core/PowerPC/PowerPC.h b/Source/Core/Core/PowerPC/PowerPC.h
index 98d281e851..29b1b8496b 100644
--- a/Source/Core/Core/PowerPC/PowerPC.h
+++ b/Source/Core/Core/PowerPC/PowerPC.h
@@ -138,6 +138,7 @@ extern PPCDebugInterface debug_interface;
 void Init(int cpu_core);
 void Shutdown();
 void DoState(PointerWrap& p);
+void ScheduleInvalidateCacheThreadSafe(u32 address);
 
 CoreMode GetMode();
 // [NOT THREADSAFE] CPU Thread or CPU::PauseAndLock or CORE_UNINITIALIZED