diff --git a/Source/Android/jni/MainAndroid.cpp b/Source/Android/jni/MainAndroid.cpp
index 1b698d2a17..3e9ff48b67 100644
--- a/Source/Android/jni/MainAndroid.cpp
+++ b/Source/Android/jni/MainAndroid.cpp
@@ -151,6 +151,12 @@ bool Host_RendererHasFocus()
   return true;
 }
 
+bool Host_RendererHasFullFocus()
+{
+  // Mouse cursor locking actually exists in Android but we don't implement (nor need) that
+  return true;
+}
+
 bool Host_RendererIsFullscreen()
 {
   return false;
diff --git a/Source/Core/Core/ConfigManager.cpp b/Source/Core/Core/ConfigManager.cpp
index e65fd6522e..ab9c9e26fd 100644
--- a/Source/Core/Core/ConfigManager.cpp
+++ b/Source/Core/Core/ConfigManager.cpp
@@ -147,6 +147,7 @@ void SConfig::SaveInterfaceSettings(IniFile& ini)
 
   interface->Set("ConfirmStop", bConfirmStop);
   interface->Set("HideCursor", bHideCursor);
+  interface->Set("LockCursor", bLockCursor);
   interface->Set("LanguageCode", m_InterfaceLanguage);
   interface->Set("ExtendedFPSInfo", m_InterfaceExtendedFPSInfo);
   interface->Set("ShowActiveTitle", m_show_active_title);
@@ -401,6 +402,7 @@ void SConfig::LoadInterfaceSettings(IniFile& ini)
 
   interface->Get("ConfirmStop", &bConfirmStop, true);
   interface->Get("HideCursor", &bHideCursor, false);
+  interface->Get("LockCursor", &bLockCursor, false);
   interface->Get("LanguageCode", &m_InterfaceLanguage, "");
   interface->Get("ExtendedFPSInfo", &m_InterfaceExtendedFPSInfo, false);
   interface->Get("ShowActiveTitle", &m_show_active_title, true);
diff --git a/Source/Core/Core/ConfigManager.h b/Source/Core/Core/ConfigManager.h
index 38c6abad74..995b84ab8f 100644
--- a/Source/Core/Core/ConfigManager.h
+++ b/Source/Core/Core/ConfigManager.h
@@ -150,6 +150,7 @@ struct SConfig
   // Interface settings
   bool bConfirmStop = false;
   bool bHideCursor = false;
+  bool bLockCursor = false;
   std::string theme_name;
 
   // Bluetooth passthrough mode settings
diff --git a/Source/Core/Core/Core.cpp b/Source/Core/Core/Core.cpp
index a3f7036584..1ec847cecc 100644
--- a/Source/Core/Core/Core.cpp
+++ b/Source/Core/Core/Core.cpp
@@ -1113,10 +1113,15 @@ void DoFrameStep()
   }
 }
 
-void UpdateInputGate(bool require_focus)
+void UpdateInputGate(bool require_focus, bool require_full_focus)
 {
-  ControlReference::SetInputGate((!require_focus || Host_RendererHasFocus()) &&
-                                 !Host_UIBlocksControllerState());
+  // If the user accepts background input, controls should pass even if an on screen interface is on
+  const bool focus_passes =
+      !require_focus || (Host_RendererHasFocus() && !Host_UIBlocksControllerState());
+  // Ignore full focus if we don't require basic focus
+  const bool full_focus_passes =
+      !require_focus || !require_full_focus || (focus_passes && Host_RendererHasFullFocus());
+  ControlReference::SetInputGate(focus_passes && full_focus_passes);
 }
 
 }  // namespace Core
diff --git a/Source/Core/Core/Core.h b/Source/Core/Core/Core.h
index d21719f218..681ffbac87 100644
--- a/Source/Core/Core/Core.h
+++ b/Source/Core/Core/Core.h
@@ -169,6 +169,6 @@ void HostDispatchJobs();
 
 void DoFrameStep();
 
-void UpdateInputGate(bool require_focus);
+void UpdateInputGate(bool require_focus, bool require_full_focus = false);
 
 }  // namespace Core
diff --git a/Source/Core/Core/HW/VideoInterface.cpp b/Source/Core/Core/HW/VideoInterface.cpp
index 0bcdd8df88..e198cb312b 100644
--- a/Source/Core/Core/HW/VideoInterface.cpp
+++ b/Source/Core/Core/HW/VideoInterface.cpp
@@ -867,7 +867,8 @@ void Update(u64 ticks)
 
   if (s_half_line_of_next_si_poll == s_half_line_count)
   {
-    Core::UpdateInputGate(!SConfig::GetInstance().m_BackgroundInput);
+    Core::UpdateInputGate(!SConfig::GetInstance().m_BackgroundInput,
+                          SConfig::GetInstance().bLockCursor);
     SerialInterface::UpdateDevices();
     s_half_line_of_next_si_poll += 2 * SerialInterface::GetPollXLines();
   }
diff --git a/Source/Core/Core/Host.h b/Source/Core/Core/Host.h
index ec539a01d2..580d7eae64 100644
--- a/Source/Core/Core/Host.h
+++ b/Source/Core/Core/Host.h
@@ -36,6 +36,7 @@ enum class HostMessageID
 std::vector<std::string> Host_GetPreferredLocales();
 bool Host_UIBlocksControllerState();
 bool Host_RendererHasFocus();
+bool Host_RendererHasFullFocus();
 bool Host_RendererIsFullscreen();
 
 void Host_Message(HostMessageID id);
diff --git a/Source/Core/Core/HotkeyManager.cpp b/Source/Core/Core/HotkeyManager.cpp
index f9c02e02e9..cd92572db9 100644
--- a/Source/Core/Core/HotkeyManager.cpp
+++ b/Source/Core/Core/HotkeyManager.cpp
@@ -24,7 +24,7 @@
 #include "InputCommon/GCPadStatus.h"
 
 // clang-format off
-constexpr std::array<const char*, 125> s_hotkey_labels{{
+constexpr std::array<const char*, 126> s_hotkey_labels{{
     _trans("Open"),
     _trans("Change Disc"),
     _trans("Eject Disc"),
@@ -35,6 +35,7 @@ constexpr std::array<const char*, 125> s_hotkey_labels{{
     _trans("Toggle Fullscreen"),
     _trans("Take Screenshot"),
     _trans("Exit"),
+    _trans("Unlock Cursor"),
     _trans("Activate NetPlay Chat"),
     _trans("Control NetPlay Golf Mode"),
 
diff --git a/Source/Core/Core/HotkeyManager.h b/Source/Core/Core/HotkeyManager.h
index 8bce8f86fe..66732f7d24 100644
--- a/Source/Core/Core/HotkeyManager.h
+++ b/Source/Core/Core/HotkeyManager.h
@@ -29,6 +29,7 @@ enum Hotkey
   HK_FULLSCREEN,
   HK_SCREENSHOT,
   HK_EXIT,
+  HK_UNLOCK_CURSOR,
   HK_ACTIVATE_CHAT,
   HK_REQUEST_GOLF_CONTROL,
 
diff --git a/Source/Core/DolphinNoGUI/MainNoGUI.cpp b/Source/Core/DolphinNoGUI/MainNoGUI.cpp
index 7c64a5cbeb..dceecc789c 100644
--- a/Source/Core/DolphinNoGUI/MainNoGUI.cpp
+++ b/Source/Core/DolphinNoGUI/MainNoGUI.cpp
@@ -98,6 +98,12 @@ bool Host_RendererHasFocus()
   return s_platform->IsWindowFocused();
 }
 
+bool Host_RendererHasFullFocus()
+{
+  // Mouse capturing isn't implemented
+  return Host_RendererHasFocus();
+}
+
 bool Host_RendererIsFullscreen()
 {
   return s_platform->IsWindowFullscreen();
diff --git a/Source/Core/DolphinNoGUI/Platform.h b/Source/Core/DolphinNoGUI/Platform.h
index b0d98e58be..f97d81855f 100644
--- a/Source/Core/DolphinNoGUI/Platform.h
+++ b/Source/Core/DolphinNoGUI/Platform.h
@@ -51,6 +51,6 @@ protected:
   Common::Flag m_shutdown_requested{false};
   Common::Flag m_tried_graceful_shutdown{false};
 
-  bool m_window_focus = true;
+  bool m_window_focus = true;  // Should be made atomic if actually implemented
   bool m_window_fullscreen = false;
 };
diff --git a/Source/Core/DolphinQt/Host.cpp b/Source/Core/DolphinQt/Host.cpp
index fdf0309b26..b0cfb507bd 100644
--- a/Source/Core/DolphinQt/Host.cpp
+++ b/Source/Core/DolphinQt/Host.cpp
@@ -10,6 +10,10 @@
 
 #include <imgui.h>
 
+#ifdef _WIN32
+#include <windows.h>
+#endif
+
 #include "Common/Common.h"
 
 #include "Core/Config/MainSettings.h"
@@ -49,6 +53,8 @@ Host* Host::GetInstance()
 
 void Host::SetRenderHandle(void* handle)
 {
+  m_render_to_main = Config::Get(Config::MAIN_RENDER_TO_MAIN);
+
   if (m_render_handle == handle)
     return;
 
@@ -61,9 +67,27 @@ void Host::SetRenderHandle(void* handle)
   }
 }
 
+void Host::SetMainWindowHandle(void* handle)
+{
+  m_main_window_handle = handle;
+}
+
 bool Host::GetRenderFocus()
 {
+#ifdef _WIN32
+  // Unfortunately Qt calls SetRenderFocus() with a slight delay compared to what we actually need
+  // to avoid inputs that cause a focus loss to be processed by the emulation
+  if (m_render_to_main)
+    return GetForegroundWindow() == (HWND)m_main_window_handle.load();
+  return GetForegroundWindow() == (HWND)m_render_handle.load();
+#else
   return m_render_focus;
+#endif
+}
+
+bool Host::GetRenderFullFocus()
+{
+  return m_render_full_focus;
 }
 
 void Host::SetRenderFocus(bool focus)
@@ -76,6 +100,11 @@ void Host::SetRenderFocus(bool focus)
     });
 }
 
+void Host::SetRenderFullFocus(bool focus)
+{
+  m_render_full_focus = focus;
+}
+
 bool Host::GetRenderFullscreen()
 {
   return m_render_fullscreen;
@@ -131,6 +160,11 @@ bool Host_RendererHasFocus()
   return Host::GetInstance()->GetRenderFocus();
 }
 
+bool Host_RendererHasFullFocus()
+{
+  return Host::GetInstance()->GetRenderFullFocus();
+}
+
 bool Host_RendererIsFullscreen()
 {
   return Host::GetInstance()->GetRenderFullscreen();
diff --git a/Source/Core/DolphinQt/Host.h b/Source/Core/DolphinQt/Host.h
index 090e620336..6be28d5464 100644
--- a/Source/Core/DolphinQt/Host.h
+++ b/Source/Core/DolphinQt/Host.h
@@ -23,10 +23,13 @@ public:
   static Host* GetInstance();
 
   bool GetRenderFocus();
+  bool GetRenderFullFocus();
   bool GetRenderFullscreen();
 
+  void SetMainWindowHandle(void* handle);
   void SetRenderHandle(void* handle);
   void SetRenderFocus(bool focus);
+  void SetRenderFullFocus(bool focus);
   void SetRenderFullscreen(bool fullscreen);
   void ResizeSurface(int new_width, int new_height);
   void RequestNotifyMapLoaded();
@@ -42,6 +45,9 @@ private:
   Host();
 
   std::atomic<void*> m_render_handle{nullptr};
+  std::atomic<void*> m_main_window_handle{nullptr};
+  std::atomic<bool> m_render_to_main{false};
   std::atomic<bool> m_render_focus{false};
+  std::atomic<bool> m_render_full_focus{false};
   std::atomic<bool> m_render_fullscreen{false};
 };
diff --git a/Source/Core/DolphinQt/HotkeyScheduler.cpp b/Source/Core/DolphinQt/HotkeyScheduler.cpp
index 30bc61aec0..85cd4d469a 100644
--- a/Source/Core/DolphinQt/HotkeyScheduler.cpp
+++ b/Source/Core/DolphinQt/HotkeyScheduler.cpp
@@ -213,6 +213,10 @@ void HotkeyScheduler::Run()
       if (IsHotkey(HK_EXIT))
         emit ExitHotkey();
 
+      // Unlock Cursor
+      if (IsHotkey(HK_UNLOCK_CURSOR))
+        emit UnlockCursor();
+
       auto& settings = Settings::Instance();
 
       // Toggle Chat
diff --git a/Source/Core/DolphinQt/HotkeyScheduler.h b/Source/Core/DolphinQt/HotkeyScheduler.h
index 4717eb4492..8ae02301ef 100644
--- a/Source/Core/DolphinQt/HotkeyScheduler.h
+++ b/Source/Core/DolphinQt/HotkeyScheduler.h
@@ -27,6 +27,7 @@ signals:
   void ChangeDisc();
 
   void ExitHotkey();
+  void UnlockCursor();
   void ActivateChat();
   void RequestGolfControl();
   void FullScreenHotkey();
diff --git a/Source/Core/DolphinQt/MainWindow.cpp b/Source/Core/DolphinQt/MainWindow.cpp
index 61e58eb19f..df580398d8 100644
--- a/Source/Core/DolphinQt/MainWindow.cpp
+++ b/Source/Core/DolphinQt/MainWindow.cpp
@@ -269,6 +269,8 @@ MainWindow::MainWindow(std::unique_ptr<BootParameters> boot_parameters,
       return;
     }
   }
+
+  Host::GetInstance()->SetMainWindowHandle(reinterpret_cast<void*>(winId()));
 }
 
 MainWindow::~MainWindow()
@@ -547,6 +549,7 @@ void MainWindow::ConnectHotkeys()
   connect(m_hotkey_scheduler, &HotkeyScheduler::ChangeDisc, this, &MainWindow::ChangeDisc);
   connect(m_hotkey_scheduler, &HotkeyScheduler::EjectDisc, this, &MainWindow::EjectDisc);
   connect(m_hotkey_scheduler, &HotkeyScheduler::ExitHotkey, this, &MainWindow::close);
+  connect(m_hotkey_scheduler, &HotkeyScheduler::UnlockCursor, this, &MainWindow::UnlockCursor);
   connect(m_hotkey_scheduler, &HotkeyScheduler::TogglePauseHotkey, this, &MainWindow::TogglePause);
   connect(m_hotkey_scheduler, &HotkeyScheduler::ActivateChat, this, &MainWindow::OnActivateChat);
   connect(m_hotkey_scheduler, &HotkeyScheduler::RequestGolfControl, this,
@@ -813,6 +816,13 @@ bool MainWindow::RequestStop()
     return true;
   }
 
+  const bool rendered_widget_was_active =
+      m_render_widget->isActiveWindow() && !m_render_widget->isFullScreen();
+  QWidget* confirm_parent = (!m_rendering_to_main && rendered_widget_was_active) ?
+                                m_render_widget :
+                                static_cast<QWidget*>(this);
+  const bool was_cursor_locked = m_render_widget->IsCursorLocked();
+
   if (!m_render_widget->isFullScreen())
     m_render_widget_geometry = m_render_widget->saveGeometry();
   else
@@ -833,21 +843,44 @@ bool MainWindow::RequestStop()
     if (pause)
       Core::SetState(Core::State::Paused);
 
+    if (rendered_widget_was_active)
+    {
+      // We have to do this before creating the message box, otherwise we might receive the window
+      // activation event before we know we need to lock the cursor again.
+      m_render_widget->SetCursorLockedOnNextActivation(was_cursor_locked);
+    }
+
+    // This is to avoid any "race conditions" between the "Window Activate" message and the
+    // message box returning, which could break cursor locking depending on the order
+    m_render_widget->SetWaitingForMessageBox(true);
     auto confirm = ModalMessageBox::question(
-        m_rendering_to_main ? static_cast<QWidget*>(this) : m_render_widget, tr("Confirm"),
+        confirm_parent, tr("Confirm"),
         m_stop_requested ? tr("A shutdown is already in progress. Unsaved data "
                               "may be lost if you stop the current emulation "
                               "before it completes. Force stop?") :
                            tr("Do you want to stop the current emulation?"),
         QMessageBox::Yes | QMessageBox::No, QMessageBox::NoButton, Qt::ApplicationModal);
 
+    // If a user confirmed stopping the emulation, we do not capture the cursor again,
+    // even if the render widget will stay alive for a while.
+    // If a used rejected stopping the emulation, we instead capture the cursor again,
+    // and let them continue playing as if nothing had happened
+    // (assuming cursor locking is on).
     if (confirm != QMessageBox::Yes)
     {
+      m_render_widget->SetWaitingForMessageBox(false);
+
       if (pause)
         Core::SetState(state);
 
       return false;
     }
+    else
+    {
+      m_render_widget->SetCursorLockedOnNextActivation(false);
+      // This needs to be after SetCursorLockedOnNextActivation(false) as it depends on it
+      m_render_widget->SetWaitingForMessageBox(false);
+    }
   }
 
   OnStopRecording();
@@ -917,6 +950,12 @@ void MainWindow::FullScreen()
   }
 }
 
+void MainWindow::UnlockCursor()
+{
+  if (!m_render_widget->isFullScreen())
+    m_render_widget->SetCursorLocked(false);
+}
+
 void MainWindow::ScreenShot()
 {
   Core::SaveScreenShot();
diff --git a/Source/Core/DolphinQt/MainWindow.h b/Source/Core/DolphinQt/MainWindow.h
index 60653412bb..79383b3541 100644
--- a/Source/Core/DolphinQt/MainWindow.h
+++ b/Source/Core/DolphinQt/MainWindow.h
@@ -108,6 +108,7 @@ private:
   void SetFullScreenResolution(bool fullscreen);
 
   void FullScreen();
+  void UnlockCursor();
   void ScreenShot();
 
   void CreateComponents();
diff --git a/Source/Core/DolphinQt/RenderWidget.cpp b/Source/Core/DolphinQt/RenderWidget.cpp
index 7347fa3ef8..6ce9d6336f 100644
--- a/Source/Core/DolphinQt/RenderWidget.cpp
+++ b/Source/Core/DolphinQt/RenderWidget.cpp
@@ -32,9 +32,16 @@
 #include "DolphinQt/Resources.h"
 #include "DolphinQt/Settings.h"
 
+#include "InputCommon/ControllerInterface/ControllerInterface.h"
+
 #include "VideoCommon/RenderBase.h"
 #include "VideoCommon/VideoConfig.h"
 
+#ifdef _WIN32
+#include <WinUser.h>
+#include <windef.h>
+#endif
+
 RenderWidget::RenderWidget(QWidget* parent) : QWidget(parent)
 {
   setWindowTitle(QStringLiteral("Dolphin"));
@@ -79,7 +86,10 @@ RenderWidget::RenderWidget(QWidget* parent) : QWidget(parent)
 
   connect(&Settings::Instance(), &Settings::HideCursorChanged, this,
           &RenderWidget::OnHideCursorChanged);
+  connect(&Settings::Instance(), &Settings::LockCursorChanged, this,
+          &RenderWidget::OnLockCursorChanged);
   OnHideCursorChanged();
+  OnLockCursorChanged();
   connect(&Settings::Instance(), &Settings::KeepWindowOnTopChanged, this,
           &RenderWidget::OnKeepOnTopChanged);
   OnKeepOnTopChanged(Settings::Instance().IsKeepWindowOnTopEnabled());
@@ -128,7 +138,33 @@ void RenderWidget::dropEvent(QDropEvent* event)
 
 void RenderWidget::OnHideCursorChanged()
 {
-  setCursor(Settings::Instance().GetHideCursor() ? Qt::BlankCursor : Qt::ArrowCursor);
+  UpdateCursor();
+}
+void RenderWidget::OnLockCursorChanged()
+{
+  SetCursorLocked(false);
+  UpdateCursor();
+}
+
+// Calling this at any time will set the cursor (image) to the correct state
+void RenderWidget::UpdateCursor()
+{
+  if (!Settings::Instance().GetLockCursor())
+  {
+    // Only hide if the cursor is automatically locking (it will hide on lock).
+    // "Unhide" the cursor if we lost focus, otherwise it will disappear when hovering
+    // on top of the game window in the background
+    const bool keep_on_top = (windowFlags() & Qt::WindowStaysOnTopHint) != 0;
+    const bool should_hide =
+        Settings::Instance().GetHideCursor() &&
+        (keep_on_top || SConfig::GetInstance().m_BackgroundInput || isActiveWindow());
+    setCursor(should_hide ? Qt::BlankCursor : Qt::ArrowCursor);
+  }
+  else
+  {
+    setCursor((m_cursor_locked && Settings::Instance().GetHideCursor()) ? Qt::BlankCursor :
+                                                                          Qt::ArrowCursor);
+  }
 }
 
 void RenderWidget::OnKeepOnTopChanged(bool top)
@@ -138,14 +174,22 @@ void RenderWidget::OnKeepOnTopChanged(bool top)
   setWindowFlags(top ? windowFlags() | Qt::WindowStaysOnTopHint :
                        windowFlags() & ~Qt::WindowStaysOnTopHint);
 
+  m_dont_lock_cursor_on_show = true;
   if (was_visible)
     show();
+  m_dont_lock_cursor_on_show = false;
+
+  UpdateCursor();
 }
 
 void RenderWidget::HandleCursorTimer()
 {
-  if (isActiveWindow())
+  if (!isActiveWindow())
+    return;
+  if (!Settings::Instance().GetLockCursor() || m_cursor_locked)
+  {
     setCursor(Qt::BlankCursor);
+  }
 }
 
 void RenderWidget::showFullScreen()
@@ -159,6 +203,138 @@ void RenderWidget::showFullScreen()
   emit SizeChanged(width() * dpr, height() * dpr);
 }
 
+// Lock the cursor within the window/widget internal borders, including the aspect ratio if wanted
+void RenderWidget::SetCursorLocked(bool locked, bool follow_aspect_ratio)
+{
+  // It seems like QT doesn't scale the window frame correctly with some DPIs
+  // so it might happen that the locked cursor can be on the frame of the window,
+  // being able to resize it, but that is a minor problem.
+  // As a hack, if necessary, we could always scale down the size by 2 pixel, to a min of 1 given
+  // that the size can be 0 already. We probably shouldn't scale axes already scaled by aspect ratio
+  QRect render_rect = geometry();
+  if (parentWidget())
+  {
+    render_rect.moveTopLeft(parentWidget()->mapToGlobal(render_rect.topLeft()));
+  }
+  auto scale = devicePixelRatioF();  // Seems to always be rounded on Win. Should we round results?
+  QPoint screen_offset = QPoint(0, 0);
+  if (window()->windowHandle() && window()->windowHandle()->screen())
+  {
+    screen_offset = window()->windowHandle()->screen()->geometry().topLeft();
+  }
+  render_rect.moveTopLeft(((render_rect.topLeft() - screen_offset) * scale) + screen_offset);
+  render_rect.setSize(render_rect.size() * scale);
+
+  if (follow_aspect_ratio)
+  {
+    // TODO: SetCursorLocked() should be re-called every time this value is changed?
+    // This might cause imprecisions of one pixel (but it won't cause the cursor to go over borders)
+    Common::Vec2 aspect_ratio = g_controller_interface.GetWindowInputScale();
+    if (aspect_ratio.x > 1.f)
+    {
+      const float new_half_width = float(render_rect.width()) / (aspect_ratio.x * 2.f);
+      // Only ceil if it was >= 0.25
+      const float ceiled_new_half_width = std::ceil(std::round(new_half_width * 2.f) / 2.f);
+      const int x_center = render_rect.center().x();
+      // Make a guess on which one to floor and ceil.
+      // For more precision, we should have kept the rounding point scale from above as well.
+      render_rect.setLeft(x_center - std::floor(new_half_width));
+      render_rect.setRight(x_center + ceiled_new_half_width);
+    }
+    if (aspect_ratio.y > 1.f)
+    {
+      const float new_half_height = render_rect.height() / (aspect_ratio.y * 2.f);
+      const float ceiled_new_half_height = std::ceil(std::round(new_half_height * 2.f) / 2.f);
+      const int y_center = render_rect.center().y();
+      render_rect.setTop(y_center - std::floor(new_half_height));
+      render_rect.setBottom(y_center + ceiled_new_half_height);
+    }
+  }
+
+  if (locked)
+  {
+#ifdef _WIN32
+    RECT rect;
+    rect.left = render_rect.left();
+    rect.right = render_rect.right();
+    rect.top = render_rect.top();
+    rect.bottom = render_rect.bottom();
+
+    if (ClipCursor(&rect))
+#else
+    // TODO: implement on other platforms. Probably XGrabPointer on Linux.
+    // The setting is hidden in the UI if not implemented
+    if (false)
+#endif
+    {
+      m_cursor_locked = true;
+
+      if (Settings::Instance().GetHideCursor())
+      {
+        setCursor(Qt::BlankCursor);
+      }
+
+      Host::GetInstance()->SetRenderFullFocus(true);
+    }
+  }
+  else
+  {
+#ifdef _WIN32
+    ClipCursor(nullptr);
+#endif
+
+    if (m_cursor_locked)
+    {
+      m_cursor_locked = false;
+
+      if (!Settings::Instance().GetLockCursor())
+      {
+        return;
+      }
+
+      // Center the mouse in the window if it's still active
+      // Leave it where it was otherwise, e.g. a prompt has opened or we alt tabbed.
+      if (isActiveWindow())
+      {
+        cursor().setPos(render_rect.left() + render_rect.width() / 2,
+                        render_rect.top() + render_rect.height() / 2);
+      }
+
+      // Show the cursor or the user won't know the mouse is now unlocked
+      setCursor(Qt::ArrowCursor);
+
+      Host::GetInstance()->SetRenderFullFocus(false);
+    }
+  }
+}
+
+void RenderWidget::SetCursorLockedOnNextActivation(bool locked)
+{
+  if (Settings::Instance().GetLockCursor())
+  {
+    m_lock_cursor_on_next_activation = locked;
+    return;
+  }
+  m_lock_cursor_on_next_activation = false;
+}
+
+void RenderWidget::SetWaitingForMessageBox(bool waiting_for_message_box)
+{
+  if (m_waiting_for_message_box == waiting_for_message_box)
+  {
+    return;
+  }
+  m_waiting_for_message_box = waiting_for_message_box;
+  if (!m_waiting_for_message_box && m_lock_cursor_on_next_activation && isActiveWindow())
+  {
+    if (Settings::Instance().GetLockCursor())
+    {
+      SetCursorLocked(true);
+    }
+    m_lock_cursor_on_next_activation = false;
+  }
+}
+
 bool RenderWidget::event(QEvent* event)
 {
   PassEventToImGui(event);
@@ -178,23 +354,67 @@ bool RenderWidget::event(QEvent* event)
 
     break;
   }
+  // Needed in case a new window open and it moves the mouse
+  case QEvent::WindowBlocked:
+    SetCursorLocked(false);
+    break;
   case QEvent::MouseButtonPress:
-    if (!Settings::Instance().GetHideCursor() && isActiveWindow())
+    if (isActiveWindow())
     {
-      setCursor(Qt::ArrowCursor);
-      m_mouse_timer->start(MOUSE_HIDE_DELAY);
+      // Lock the cursor with any mouse button click (behave the same as window focus change).
+      // This event is occasionally missed because isActiveWindow is laggy
+      if (Settings::Instance().GetLockCursor() && event->type() == QEvent::MouseButtonPress)
+      {
+        SetCursorLocked(true);
+      }
+      // Unhide on movement
+      if (!Settings::Instance().GetHideCursor())
+      {
+        setCursor(Qt::ArrowCursor);
+        m_mouse_timer->start(MOUSE_HIDE_DELAY);
+      }
     }
     break;
   case QEvent::WinIdChange:
     emit HandleChanged(reinterpret_cast<void*>(winId()));
     break;
+  case QEvent::Show:
+    // Don't do if "stay on top" changed (or was true)
+    if (Settings::Instance().GetLockCursor() && Settings::Instance().GetHideCursor() &&
+        !m_dont_lock_cursor_on_show)
+    {
+      // Auto lock when this window is shown (it was hidden)
+      if (isActiveWindow())
+        SetCursorLocked(true);
+      else
+        SetCursorLockedOnNextActivation();
+    }
+    break;
+  // Note that this event in Windows is not always aligned to the window that is highlighted,
+  // it's the window that has keyboard and mouse focus
   case QEvent::WindowActivate:
     if (SConfig::GetInstance().m_PauseOnFocusLost && Core::GetState() == Core::State::Paused)
       Core::SetState(Core::State::Running);
 
+    UpdateCursor();
+
+    // Avoid "race conditions" with message boxes
+    if (m_lock_cursor_on_next_activation && !m_waiting_for_message_box)
+    {
+      if (Settings::Instance().GetLockCursor())
+      {
+        SetCursorLocked(true);
+      }
+      m_lock_cursor_on_next_activation = false;
+    }
+
     emit FocusChanged(true);
     break;
   case QEvent::WindowDeactivate:
+    SetCursorLocked(false);
+
+    UpdateCursor();
+
     if (SConfig::GetInstance().m_PauseOnFocusLost && Core::GetState() == Core::State::Running)
     {
       // If we are declared as the CPU thread, it means that the real CPU thread is waiting
@@ -206,8 +426,13 @@ bool RenderWidget::event(QEvent* event)
 
     emit FocusChanged(false);
     break;
+  case QEvent::Move:
+    SetCursorLocked(m_cursor_locked);
+    break;
   case QEvent::Resize:
   {
+    SetCursorLocked(m_cursor_locked);
+
     const QResizeEvent* se = static_cast<QResizeEvent*>(event);
     QSize new_size = se->size();
 
@@ -218,14 +443,18 @@ bool RenderWidget::event(QEvent* event)
     emit SizeChanged(new_size.width() * dpr, new_size.height() * dpr);
     break;
   }
+  // Happens when we add/remove the widget from the main window instead of the dedicated one
+  case QEvent::ParentChange:
+    SetCursorLocked(false);
+    break;
   case QEvent::WindowStateChange:
+    // Lock the mouse again when fullscreen changes (we might have missed some events)
+    SetCursorLocked(m_cursor_locked || (isFullScreen() && Settings::Instance().GetLockCursor()));
     emit StateChanged(isFullScreen());
     break;
   case QEvent::Close:
     emit Closed();
     break;
-  default:
-    break;
   }
   return QWidget::event(event);
 }
diff --git a/Source/Core/DolphinQt/RenderWidget.h b/Source/Core/DolphinQt/RenderWidget.h
index 975b8399f1..0044981f9b 100644
--- a/Source/Core/DolphinQt/RenderWidget.h
+++ b/Source/Core/DolphinQt/RenderWidget.h
@@ -20,6 +20,10 @@ public:
   bool event(QEvent* event) override;
   void showFullScreen();
   QPaintEngine* paintEngine() const override;
+  bool IsCursorLocked() const { return m_cursor_locked; }
+  void SetCursorLockedOnNextActivation(bool locked = true);
+  void SetWaitingForMessageBox(bool waiting_for_message_box);
+  void SetCursorLocked(bool locked, bool follow_aspect_ratio = true);
 
 signals:
   void EscapePressed();
@@ -32,7 +36,9 @@ signals:
 private:
   void HandleCursorTimer();
   void OnHideCursorChanged();
+  void OnLockCursorChanged();
   void OnKeepOnTopChanged(bool top);
+  void UpdateCursor();
   void PassEventToImGui(const QEvent* event);
   void SetImGuiKeyMap();
   void dragEnterEvent(QDragEnterEvent* event) override;
@@ -41,4 +47,8 @@ private:
   static constexpr int MOUSE_HIDE_DELAY = 3000;
   QTimer* m_mouse_timer;
   QPoint m_last_mouse{};
+  bool m_cursor_locked = false;
+  bool m_lock_cursor_on_next_activation = false;
+  bool m_dont_lock_cursor_on_show = false;
+  bool m_waiting_for_message_box = false;
 };
diff --git a/Source/Core/DolphinQt/Settings.cpp b/Source/Core/DolphinQt/Settings.cpp
index d448ca0abf..7541a9087f 100644
--- a/Source/Core/DolphinQt/Settings.cpp
+++ b/Source/Core/DolphinQt/Settings.cpp
@@ -280,6 +280,17 @@ bool Settings::GetHideCursor() const
   return SConfig::GetInstance().bHideCursor;
 }
 
+void Settings::SetLockCursor(bool lock_cursor)
+{
+  SConfig::GetInstance().bLockCursor = lock_cursor;
+  emit LockCursorChanged();
+}
+
+bool Settings::GetLockCursor() const
+{
+  return SConfig::GetInstance().bLockCursor;
+}
+
 void Settings::SetKeepWindowOnTop(bool top)
 {
   if (IsKeepWindowOnTopEnabled() == top)
diff --git a/Source/Core/DolphinQt/Settings.h b/Source/Core/DolphinQt/Settings.h
index f3753d1d5f..d5fd90989c 100644
--- a/Source/Core/DolphinQt/Settings.h
+++ b/Source/Core/DolphinQt/Settings.h
@@ -100,6 +100,8 @@ public:
   // Graphics
   void SetHideCursor(bool hide_cursor);
   bool GetHideCursor() const;
+  void SetLockCursor(bool lock_cursor);
+  bool GetLockCursor() const;
   void SetKeepWindowOnTop(bool top);
   bool IsKeepWindowOnTopEnabled() const;
 
@@ -168,6 +170,7 @@ signals:
   void MetadataRefreshCompleted();
   void AutoRefreshToggled(bool enabled);
   void HideCursorChanged();
+  void LockCursorChanged();
   void KeepWindowOnTopChanged(bool top);
   void VolumeChanged(int volume);
   void NANDRefresh();
diff --git a/Source/Core/DolphinQt/Settings/InterfacePane.cpp b/Source/Core/DolphinQt/Settings/InterfacePane.cpp
index cd0596f319..5a0a3fa500 100644
--- a/Source/Core/DolphinQt/Settings/InterfacePane.cpp
+++ b/Source/Core/DolphinQt/Settings/InterfacePane.cpp
@@ -171,6 +171,14 @@ void InterfacePane::CreateInGame()
   m_checkbox_show_active_title = new QCheckBox(tr("Show Active Title in Window Title"));
   m_checkbox_pause_on_focus_lost = new QCheckBox(tr("Pause on Focus Loss"));
   m_checkbox_hide_mouse = new QCheckBox(tr("Always Hide Mouse Cursor"));
+  m_checkbox_lock_mouse = new QCheckBox(tr("Lock Mouse Cursor"));
+
+  m_checkbox_hide_mouse->setToolTip(
+      tr("Will immediately hide the Mouse Cursor when it hovers on top of the Render Widget, "
+         "otherwise "
+         "there is a delay.\nIf \"Lock Mouse Cursor\" is enabled, it will hide on Mouse locked"));
+  m_checkbox_lock_mouse->setToolTip(tr("Will lock the Mouse Cursor to the Render Widget as long as "
+                                       "it has focus. You can set a hotkey to unlock it."));
 
   groupbox_layout->addWidget(m_checkbox_top_window);
   groupbox_layout->addWidget(m_checkbox_confirm_on_stop);
@@ -179,6 +187,9 @@ void InterfacePane::CreateInGame()
   groupbox_layout->addWidget(m_checkbox_show_active_title);
   groupbox_layout->addWidget(m_checkbox_pause_on_focus_lost);
   groupbox_layout->addWidget(m_checkbox_hide_mouse);
+#ifdef _WIN32
+  groupbox_layout->addWidget(m_checkbox_lock_mouse);
+#endif
 }
 
 void InterfacePane::ConnectLayout()
@@ -203,6 +214,8 @@ void InterfacePane::ConnectLayout()
   connect(m_checkbox_pause_on_focus_lost, &QCheckBox::toggled, this, &InterfacePane::OnSaveConfig);
   connect(m_checkbox_hide_mouse, &QCheckBox::toggled, &Settings::Instance(),
           &Settings::SetHideCursor);
+  connect(m_checkbox_lock_mouse, &QCheckBox::toggled, &Settings::Instance(),
+          &Settings::SetLockCursor);
   connect(m_checkbox_use_userstyle, &QCheckBox::toggled, this, &InterfacePane::OnSaveConfig);
 }
 
@@ -239,6 +252,7 @@ void InterfacePane::LoadConfig()
   m_checkbox_use_covers->setChecked(Config::Get(Config::MAIN_USE_GAME_COVERS));
   m_checkbox_focused_hotkeys->setChecked(Config::Get(Config::MAIN_FOCUSED_HOTKEYS));
   m_checkbox_hide_mouse->setChecked(Settings::Instance().GetHideCursor());
+  m_checkbox_lock_mouse->setChecked(Settings::Instance().GetLockCursor());
   m_checkbox_disable_screensaver->setChecked(Config::Get(Config::MAIN_DISABLE_SCREENSAVER));
 }
 
diff --git a/Source/Core/DolphinQt/Settings/InterfacePane.h b/Source/Core/DolphinQt/Settings/InterfacePane.h
index d135de5992..6fde8d25fe 100644
--- a/Source/Core/DolphinQt/Settings/InterfacePane.h
+++ b/Source/Core/DolphinQt/Settings/InterfacePane.h
@@ -45,4 +45,5 @@ private:
   QCheckBox* m_checkbox_show_active_title;
   QCheckBox* m_checkbox_pause_on_focus_lost;
   QCheckBox* m_checkbox_hide_mouse;
+  QCheckBox* m_checkbox_lock_mouse;
 };
diff --git a/Source/DSPTool/StubHost.cpp b/Source/DSPTool/StubHost.cpp
index 19c85a642b..6dce41694b 100644
--- a/Source/DSPTool/StubHost.cpp
+++ b/Source/DSPTool/StubHost.cpp
@@ -39,6 +39,10 @@ bool Host_RendererHasFocus()
 {
   return false;
 }
+bool Host_RendererHasFullFocus()
+{
+  return false;
+}
 bool Host_RendererIsFullscreen()
 {
   return false;
diff --git a/Source/UnitTests/StubHost.cpp b/Source/UnitTests/StubHost.cpp
index 4b9db8f033..7a84a9ece9 100644
--- a/Source/UnitTests/StubHost.cpp
+++ b/Source/UnitTests/StubHost.cpp
@@ -43,6 +43,10 @@ bool Host_RendererHasFocus()
 {
   return false;
 }
+bool Host_RendererHasFullFocus()
+{
+  return false;
+}
 bool Host_RendererIsFullscreen()
 {
   return false;