diff --git a/Source/Core/DolphinQt/GameList/GameListModel.cpp b/Source/Core/DolphinQt/GameList/GameListModel.cpp
index a930d66607..c70a870c23 100644
--- a/Source/Core/DolphinQt/GameList/GameListModel.cpp
+++ b/Source/Core/DolphinQt/GameList/GameListModel.cpp
@@ -92,14 +92,14 @@ QVariant GameListModel::data(const QModelIndex& index, int role) const
     {
       QString name = QString::fromStdString(game.GetName(m_title_database));
 
-      // Add disc numbers > 1 to title if not present.
-      const int disc_nr = game.GetDiscNumber() + 1;
-      if (disc_nr > 1)
+      const int disc_number = game.GetDiscNumber() + 1;
+      if (disc_number > 1 || game.IsTwoDiscGame())
       {
-        if (!name.contains(QRegularExpression(QStringLiteral("disc ?%1").arg(disc_nr),
+        // Add disc number to title if not present.
+        if (!name.contains(QRegularExpression(QStringLiteral("disc ?%1").arg(disc_number),
                                               QRegularExpression::CaseInsensitiveOption)))
         {
-          name.append(tr(" (Disc %1)").arg(disc_nr));
+          name.append(tr(" (Disc %1)").arg(disc_number));
         }
       }
 
diff --git a/Source/Core/UICommon/GameFile.cpp b/Source/Core/UICommon/GameFile.cpp
index 470016d1bd..7603463138 100644
--- a/Source/Core/UICommon/GameFile.cpp
+++ b/Source/Core/UICommon/GameFile.cpp
@@ -135,6 +135,7 @@ GameFile::GameFile(std::string path) : m_file_path(std::move(path))
       m_maker_id = volume->GetMakerID();
       m_revision = volume->GetRevision().value_or(0);
       m_disc_number = volume->GetDiscNumber().value_or(0);
+      m_is_two_disc_game = CheckIfTwoDiscGame(m_game_id);
       m_apploader_date = volume->GetApploaderDate();
 
       m_volume_banner.buffer = volume->GetBanner(&m_volume_banner.width, &m_volume_banner.height);
@@ -321,6 +322,7 @@ void GameFile::DoState(PointerWrap& p)
   p.Do(m_compression_method);
   p.Do(m_revision);
   p.Do(m_disc_number);
+  p.Do(m_is_two_disc_game);
   p.Do(m_apploader_date);
 
   p.Do(m_custom_name);
@@ -547,6 +549,77 @@ std::vector<DiscIO::Language> GameFile::GetLanguages() const
   return languages;
 }
 
+bool GameFile::CheckIfTwoDiscGame(const std::string& game_id) const
+{
+  constexpr size_t GAME_ID_PREFIX_SIZE = 3;
+  if (game_id.size() < GAME_ID_PREFIX_SIZE)
+    return false;
+
+  static constexpr std::array<std::string_view, 30> two_disc_game_id_prefixes = {
+      // Resident Evil
+      "DBJ",
+      // The Lord of the Rings: The Third Age
+      "G3A",
+      // Teenage Mutant Ninja Turtles 3: Mutant Nightmare
+      "G3Q",
+      // Resident Evil 4
+      "G4B",
+      // Tiger Woods PGA Tour 2005
+      "G5T",
+      // Resident Evil
+      "GBI",
+      // Resident Evil Zero
+      "GBZ",
+      // Conan
+      "GC9",
+      // Resident Evil Code: Veronica X
+      "GCD",
+      // Tom Clancy's Splinter Cell: Chaos Theory
+      "GCJ",
+      // Freaky Flyers
+      "GFF",
+      // GoldenEye: Rogue Agent
+      "GGI",
+      // Metal Gear Solid: The Twin Snakes
+      "GGS",
+      // Baten Kaitos Origins
+      "GK4",
+      // Killer7
+      "GK7",
+      // Baten Kaitos: Eternal Wings and the Lost Ocean
+      "GKB",
+      // Lupin the 3rd: Lost Treasure by the Sea
+      "GL3",
+      // Enter the Matrix
+      "GMX",
+      // Teenage Mutant Ninja Turtles 2: Battle Nexus
+      "GNI",
+      // GoldenEye: Rogue Agent
+      "GOY",
+      // Tales of Symphonia
+      "GQS",
+      // Medal of Honor: Rising Sun
+      "GR8",
+      "GRZ",
+      // Tales of Symphonia
+      "GTO",
+      // Tiger Woods PGA Tour 2004
+      "GW4",
+      // Tom Clancy's Splinter Cell: Double Agent (GC)
+      "GWY",
+      // Dragon Quest X: Mezameshi Itsutsu no Shuzoku Online
+      "S4M",
+      "S4S",
+      "S6T",
+      "SDQ",
+  };
+  static_assert(std::is_sorted(two_disc_game_id_prefixes.begin(), two_disc_game_id_prefixes.end()));
+
+  std::string_view game_id_prefix(game_id.data(), GAME_ID_PREFIX_SIZE);
+  return std::binary_search(two_disc_game_id_prefixes.begin(), two_disc_game_id_prefixes.end(),
+                            game_id_prefix);
+}
+
 std::string GameFile::GetNetPlayName(const Core::TitleDatabase& title_database) const
 {
   std::vector<std::string> info;
diff --git a/Source/Core/UICommon/GameFile.h b/Source/Core/UICommon/GameFile.h
index 32fb9278aa..e43950143b 100644
--- a/Source/Core/UICommon/GameFile.h
+++ b/Source/Core/UICommon/GameFile.h
@@ -81,6 +81,7 @@ public:
   u16 GetRevision() const { return m_revision; }
   // 0 is the first disc, 1 is the second disc
   u8 GetDiscNumber() const { return m_disc_number; }
+  bool IsTwoDiscGame() const { return m_is_two_disc_game; }
   std::string GetNetPlayName(const Core::TitleDatabase& title_database) const;
 
   // This function is slow
@@ -134,6 +135,7 @@ private:
   bool ReadXMLMetadata(const std::string& path);
   bool ReadPNGBanner(const std::string& path);
   bool TryLoadGameModDescriptorBanner();
+  bool CheckIfTwoDiscGame(const std::string& game_id) const;
 
   // IMPORTANT: Nearly all data members must be save/restored in DoState.
   // If anything is changed, make sure DoState handles it properly and
@@ -168,6 +170,7 @@ private:
   std::string m_compression_method{};
   u16 m_revision{};
   u8 m_disc_number{};
+  bool m_is_two_disc_game{};
   std::string m_apploader_date;
 
   std::string m_custom_name;
diff --git a/Source/Core/UICommon/GameFileCache.cpp b/Source/Core/UICommon/GameFileCache.cpp
index 2838d331d8..d5b970d29c 100644
--- a/Source/Core/UICommon/GameFileCache.cpp
+++ b/Source/Core/UICommon/GameFileCache.cpp
@@ -26,7 +26,7 @@
 
 namespace UICommon
 {
-static constexpr u32 CACHE_REVISION = 24;  // Last changed in PR 11557
+static constexpr u32 CACHE_REVISION = 25;  // Last changed in PR 12702
 
 std::vector<std::string> FindAllGamePaths(const std::vector<std::string>& directories_to_scan,
                                           bool recursive_scan)