diff --git a/Source/Core/DolphinWX/Frame.cpp b/Source/Core/DolphinWX/Frame.cpp
index 184e9e681e..3c47217525 100644
--- a/Source/Core/DolphinWX/Frame.cpp
+++ b/Source/Core/DolphinWX/Frame.cpp
@@ -244,6 +244,7 @@ EVT_MENU_RANGE(IDM_FLOAT_LOG_WINDOW, IDM_FLOAT_CODE_WINDOW, CFrame::OnFloatWindo
 
 // Game list context menu
 EVT_MENU(IDM_LIST_INSTALL_WAD, CFrame::OnInstallWAD)
+EVT_MENU(IDM_LIST_UNINSTALL_WAD, CFrame::OnUninstallWAD)
 
 // Other
 EVT_ACTIVATE(CFrame::OnActive)
diff --git a/Source/Core/DolphinWX/Frame.h b/Source/Core/DolphinWX/Frame.h
index 236b0ac8be..e404d7858f 100644
--- a/Source/Core/DolphinWX/Frame.h
+++ b/Source/Core/DolphinWX/Frame.h
@@ -316,6 +316,7 @@ private:
   void OnShowCheatsWindow(wxCommandEvent& event);
   void OnLoadWiiMenu(wxCommandEvent& event);
   void OnInstallWAD(wxCommandEvent& event);
+  void OnUninstallWAD(wxCommandEvent& event);
   void OnImportBootMiiBackup(wxCommandEvent& event);
   void OnExtractCertificates(wxCommandEvent& event);
   void OnFifoPlayer(wxCommandEvent& event);
diff --git a/Source/Core/DolphinWX/FrameTools.cpp b/Source/Core/DolphinWX/FrameTools.cpp
index 996c7770a6..9dd9c7a9a2 100644
--- a/Source/Core/DolphinWX/FrameTools.cpp
+++ b/Source/Core/DolphinWX/FrameTools.cpp
@@ -53,6 +53,8 @@
 
 #include "DiscIO/NANDContentLoader.h"
 #include "DiscIO/NANDImporter.h"
+#include "DiscIO/VolumeCreator.h"
+#include "DiscIO/VolumeWad.h"
 
 #include "DolphinWX/AboutDolphin.h"
 #include "DolphinWX/Cheats/CheatsWindow.h"
@@ -1228,6 +1230,31 @@ void CFrame::OnInstallWAD(wxCommandEvent& event)
   }
 }
 
+void CFrame::OnUninstallWAD(wxCommandEvent&)
+{
+  const GameListItem* file = m_GameListCtrl->GetSelectedISO();
+  if (!file)
+    return;
+
+  if (!AskYesNoT("Uninstalling the WAD will remove the currently installed version "
+                 "of this title from the NAND without deleting its save data. Continue?"))
+  {
+    return;
+  }
+
+  const auto volume = DiscIO::CreateVolumeFromFilename(file->GetFileName());
+  u64 title_id;
+  volume->GetTitleID(&title_id);
+  if (!DiscIO::CNANDContentManager::Access().RemoveTitle(title_id, Common::FROM_CONFIGURED_ROOT))
+  {
+    PanicAlertT("Failed to remove this title from the NAND.");
+    return;
+  }
+
+  if (title_id == TITLEID_SYSMENU)
+    UpdateLoadWiiMenuItem();
+}
+
 void CFrame::OnImportBootMiiBackup(wxCommandEvent& WXUNUSED(event))
 {
   if (!AskYesNoT("Merging a new NAND over your currently selected NAND will overwrite any channels "
diff --git a/Source/Core/DolphinWX/GameListCtrl.cpp b/Source/Core/DolphinWX/GameListCtrl.cpp
index a1bbb00928..738ca91196 100644
--- a/Source/Core/DolphinWX/GameListCtrl.cpp
+++ b/Source/Core/DolphinWX/GameListCtrl.cpp
@@ -956,6 +956,27 @@ void CGameListCtrl::OnLeftClick(wxMouseEvent& event)
   event.Skip();
 }
 
+static bool IsWADInstalled(const std::string& wad_path)
+{
+  const auto volume = DiscIO::CreateVolumeFromFilename(wad_path);
+  u64 title_id;
+  if (!volume || !volume->GetTitleID(&title_id))
+    return false;
+
+  const std::string content_dir =
+      Common::GetTitleContentPath(title_id, Common::FromWhichRoot::FROM_CONFIGURED_ROOT);
+
+  if (!File::IsDirectory(content_dir))
+    return false;
+
+  // Since this isn't IOS and we only need a simple way to figure out if a title is installed,
+  // we make the (reasonable) assumption that having more than just the TMD in the content
+  // directory means that the title is installed.
+  const auto entries = File::ScanDirectoryTree(content_dir, false);
+  return std::any_of(entries.children.begin(), entries.children.end(),
+                     [](const auto& file) { return file.virtualName != "title.tmd"; });
+}
+
 void CGameListCtrl::OnRightClick(wxMouseEvent& event)
 {
   // Focus the clicked item.
@@ -1024,9 +1045,15 @@ void CGameListCtrl::OnRightClick(wxMouseEvent& event)
       if (platform == DiscIO::Platform::WII_WAD)
       {
         auto* const install_wad_item =
-            popupMenu.Append(IDM_LIST_INSTALL_WAD, _("Install to Wii Menu"));
-        // This should not be allowed while emulation is running, just like the Install WAD option.
-        install_wad_item->Enable(!Core::IsRunning() || !SConfig::GetInstance().bWii);
+            popupMenu.Append(IDM_LIST_INSTALL_WAD, _("Install to the NAND"));
+        auto* const uninstall_wad_item =
+            popupMenu.Append(IDM_LIST_UNINSTALL_WAD, _("Uninstall from the NAND"));
+        // These should not be allowed while emulation is running for safety reasons.
+        for (auto* menu_item : {install_wad_item, uninstall_wad_item})
+          menu_item->Enable(!Core::IsRunning() || !SConfig::GetInstance().bWii);
+
+        if (!IsWADInstalled(selected_iso->GetFileName()))
+          uninstall_wad_item->Enable(false);
       }
 
       popupMenu.Append(IDM_START_NETPLAY, _("Host with Netplay"));
diff --git a/Source/Core/DolphinWX/Globals.h b/Source/Core/DolphinWX/Globals.h
index 9dfc6bc0e4..64ef00a951 100644
--- a/Source/Core/DolphinWX/Globals.h
+++ b/Source/Core/DolphinWX/Globals.h
@@ -101,6 +101,7 @@ enum
   IDM_LOAD_WII_MENU,
   IDM_MENU_INSTALL_WAD,
   IDM_LIST_INSTALL_WAD,
+  IDM_LIST_UNINSTALL_WAD,
   IDM_IMPORT_NAND,
   IDM_EXTRACT_CERTIFICATES,
   IDM_FIFOPLAYER,