diff --git a/Source/Core/VideoBackends/D3D/main.cpp b/Source/Core/VideoBackends/D3D/main.cpp
index f29e079d61..26a8c4dcfd 100644
--- a/Source/Core/VideoBackends/D3D/main.cpp
+++ b/Source/Core/VideoBackends/D3D/main.cpp
@@ -82,6 +82,7 @@ void VideoBackend::InitBackendInfo()
   g_Config.backend_info.bSupportsBitfield = false;
   g_Config.backend_info.bSupportsDynamicSamplerIndexing = false;
   g_Config.backend_info.bSupportsBPTCTextures = false;
+  g_Config.backend_info.bSupportsFramebufferFetch = false;
 
   IDXGIFactory2* factory;
   IDXGIAdapter* ad;
diff --git a/Source/Core/VideoBackends/Null/NullBackend.cpp b/Source/Core/VideoBackends/Null/NullBackend.cpp
index d6c9638763..4ea460e440 100644
--- a/Source/Core/VideoBackends/Null/NullBackend.cpp
+++ b/Source/Core/VideoBackends/Null/NullBackend.cpp
@@ -46,6 +46,7 @@ void VideoBackend::InitBackendInfo()
   g_Config.backend_info.bSupportsGPUTextureDecoding = false;
   g_Config.backend_info.bSupportsST3CTextures = false;
   g_Config.backend_info.bSupportsBPTCTextures = false;
+  g_Config.backend_info.bSupportsFramebufferFetch = false;
 
   // aamodes: We only support 1 sample, so no MSAA
   g_Config.backend_info.Adapters.clear();
diff --git a/Source/Core/VideoBackends/OGL/ProgramShaderCache.cpp b/Source/Core/VideoBackends/OGL/ProgramShaderCache.cpp
index a5133023af..54b5c87100 100644
--- a/Source/Core/VideoBackends/OGL/ProgramShaderCache.cpp
+++ b/Source/Core/VideoBackends/OGL/ProgramShaderCache.cpp
@@ -885,6 +885,24 @@ void ProgramShaderCache::CreateHeader()
     }
   }
 
+  std::string framebuffer_fetch_string;
+  switch (g_ogl_config.SupportedFramebufferFetch)
+  {
+  case ES_FB_FETCH_TYPE::FB_FETCH_EXT:
+    framebuffer_fetch_string = "#extension GL_EXT_shader_framebuffer_fetch: enable\n"
+                               "#define FB_FETCH_VALUE ocol0\n"
+                               "#define FRAGMENT_INOUT inout";
+    break;
+  case ES_FB_FETCH_TYPE::FB_FETCH_ARM:
+    framebuffer_fetch_string = "#extension GL_ARM_shader_framebuffer_fetch: enable\n"
+                               "#define FB_FETCH_VALUE gl_LastFragColorARM\n"
+                               "#define FRAGMENT_INOUT out";
+    break;
+  case ES_FB_FETCH_TYPE::FB_FETCH_NONE:
+    framebuffer_fetch_string = "";
+    break;
+  }
+
   s_glsl_header = StringFromFormat(
       "%s\n"
       "%s\n"  // ubo
@@ -902,6 +920,7 @@ void ProgramShaderCache::CreateHeader()
       "%s\n"  // ES texture buffer
       "%s\n"  // ES dual source blend
       "%s\n"  // shader image load store
+      "%s\n"  // shader framebuffer fetch
 
       // Precision defines for GLSL ES
       "%s\n"
@@ -976,8 +995,8 @@ void ProgramShaderCache::CreateHeader()
               ((!is_glsles && v < GLSL_430) || (is_glsles && v < GLSLES_310)) ?
           "#extension GL_ARB_shader_image_load_store : enable" :
           "",
-      is_glsles ? "precision highp float;" : "", is_glsles ? "precision highp int;" : "",
-      is_glsles ? "precision highp sampler2DArray;" : "",
+      framebuffer_fetch_string.c_str(), is_glsles ? "precision highp float;" : "",
+      is_glsles ? "precision highp int;" : "", is_glsles ? "precision highp sampler2DArray;" : "",
       (is_glsles && g_ActiveConfig.backend_info.bSupportsPaletteConversion) ?
           "precision highp usamplerBuffer;" :
           "",
diff --git a/Source/Core/VideoBackends/OGL/Render.cpp b/Source/Core/VideoBackends/OGL/Render.cpp
index 428492c72a..7d3fa22f5d 100644
--- a/Source/Core/VideoBackends/OGL/Render.cpp
+++ b/Source/Core/VideoBackends/OGL/Render.cpp
@@ -522,6 +522,21 @@ Renderer::Renderer()
     // depth clamping.
     g_Config.backend_info.bSupportsDepthClamp = false;
 
+    if (GLExtensions::Supports("GL_EXT_shader_framebuffer_fetch"))
+    {
+      g_ogl_config.SupportedFramebufferFetch = ES_FB_FETCH_TYPE::FB_FETCH_EXT;
+    }
+    else if (GLExtensions::Supports("GL_ARM_shader_framebuffer_fetch"))
+    {
+      g_ogl_config.SupportedFramebufferFetch = ES_FB_FETCH_TYPE::FB_FETCH_ARM;
+    }
+    else
+    {
+      g_ogl_config.SupportedFramebufferFetch = ES_FB_FETCH_TYPE::FB_FETCH_NONE;
+    }
+    g_Config.backend_info.bSupportsFramebufferFetch =
+        g_ogl_config.SupportedFramebufferFetch != ES_FB_FETCH_TYPE::FB_FETCH_NONE;
+
     if (GLExtensions::Version() == 300)
     {
       g_ogl_config.eSupportedGLSLVersion = GLSLES_300;
@@ -1275,44 +1290,54 @@ void Renderer::SetBlendingState(const BlendingState& state)
   bool useDualSource =
       state.usedualsrc && g_ActiveConfig.backend_info.bSupportsDualSourceBlend &&
       (!DriverDetails::HasBug(DriverDetails::BUG_BROKEN_DUAL_SOURCE_BLENDING) || state.dstalpha);
+  // Only use shader blend if we need to and we don't support dual-source blending directly
+  bool useShaderBlend = !useDualSource && state.usedualsrc && state.dstalpha &&
+                        g_ActiveConfig.backend_info.bSupportsFramebufferFetch;
 
-  const GLenum src_factors[8] = {
-      GL_ZERO,
-      GL_ONE,
-      GL_DST_COLOR,
-      GL_ONE_MINUS_DST_COLOR,
-      useDualSource ? GL_SRC1_ALPHA : (GLenum)GL_SRC_ALPHA,
-      useDualSource ? GL_ONE_MINUS_SRC1_ALPHA : (GLenum)GL_ONE_MINUS_SRC_ALPHA,
-      GL_DST_ALPHA,
-      GL_ONE_MINUS_DST_ALPHA};
-  const GLenum dst_factors[8] = {
-      GL_ZERO,
-      GL_ONE,
-      GL_SRC_COLOR,
-      GL_ONE_MINUS_SRC_COLOR,
-      useDualSource ? GL_SRC1_ALPHA : (GLenum)GL_SRC_ALPHA,
-      useDualSource ? GL_ONE_MINUS_SRC1_ALPHA : (GLenum)GL_ONE_MINUS_SRC_ALPHA,
-      GL_DST_ALPHA,
-      GL_ONE_MINUS_DST_ALPHA};
-
-  if (state.blendenable)
-  {
-    glEnable(GL_BLEND);
-  }
-  else
+  if (useShaderBlend)
   {
     glDisable(GL_BLEND);
   }
+  else
+  {
+    const GLenum src_factors[8] = {
+        GL_ZERO,
+        GL_ONE,
+        GL_DST_COLOR,
+        GL_ONE_MINUS_DST_COLOR,
+        useDualSource ? GL_SRC1_ALPHA : (GLenum)GL_SRC_ALPHA,
+        useDualSource ? GL_ONE_MINUS_SRC1_ALPHA : (GLenum)GL_ONE_MINUS_SRC_ALPHA,
+        GL_DST_ALPHA,
+        GL_ONE_MINUS_DST_ALPHA};
+    const GLenum dst_factors[8] = {
+        GL_ZERO,
+        GL_ONE,
+        GL_SRC_COLOR,
+        GL_ONE_MINUS_SRC_COLOR,
+        useDualSource ? GL_SRC1_ALPHA : (GLenum)GL_SRC_ALPHA,
+        useDualSource ? GL_ONE_MINUS_SRC1_ALPHA : (GLenum)GL_ONE_MINUS_SRC_ALPHA,
+        GL_DST_ALPHA,
+        GL_ONE_MINUS_DST_ALPHA};
 
-  // Always call glBlendEquationSeparate and glBlendFuncSeparate, even when
-  // GL_BLEND is disabled, as a workaround for some bugs (possibly graphics
-  // driver issues?). See https://bugs.dolphin-emu.org/issues/10120 : "Sonic
-  // Adventure 2 Battle: graphics crash when loading first Dark level"
-  GLenum equation = state.subtract ? GL_FUNC_REVERSE_SUBTRACT : GL_FUNC_ADD;
-  GLenum equationAlpha = state.subtractAlpha ? GL_FUNC_REVERSE_SUBTRACT : GL_FUNC_ADD;
-  glBlendEquationSeparate(equation, equationAlpha);
-  glBlendFuncSeparate(src_factors[state.srcfactor], dst_factors[state.dstfactor],
-                      src_factors[state.srcfactoralpha], dst_factors[state.dstfactoralpha]);
+    if (state.blendenable)
+    {
+      glEnable(GL_BLEND);
+    }
+    else
+    {
+      glDisable(GL_BLEND);
+    }
+
+    // Always call glBlendEquationSeparate and glBlendFuncSeparate, even when
+    // GL_BLEND is disabled, as a workaround for some bugs (possibly graphics
+    // driver issues?). See https://bugs.dolphin-emu.org/issues/10120 : "Sonic
+    // Adventure 2 Battle: graphics crash when loading first Dark level"
+    GLenum equation = state.subtract ? GL_FUNC_REVERSE_SUBTRACT : GL_FUNC_ADD;
+    GLenum equationAlpha = state.subtractAlpha ? GL_FUNC_REVERSE_SUBTRACT : GL_FUNC_ADD;
+    glBlendEquationSeparate(equation, equationAlpha);
+    glBlendFuncSeparate(src_factors[state.srcfactor], dst_factors[state.dstfactor],
+                        src_factors[state.srcfactoralpha], dst_factors[state.dstfactoralpha]);
+  }
 
   const GLenum logic_op_codes[16] = {
       GL_CLEAR,         GL_AND,         GL_AND_REVERSE, GL_COPY,  GL_AND_INVERTED, GL_NOOP,
diff --git a/Source/Core/VideoBackends/OGL/Render.h b/Source/Core/VideoBackends/OGL/Render.h
index e787828d53..099b63254f 100644
--- a/Source/Core/VideoBackends/OGL/Render.h
+++ b/Source/Core/VideoBackends/OGL/Render.h
@@ -35,6 +35,13 @@ enum class ES_TEXBUF_TYPE
   TEXBUF_EXT
 };
 
+enum class ES_FB_FETCH_TYPE
+{
+  FB_FETCH_NONE,
+  FB_FETCH_EXT,
+  FB_FETCH_ARM,
+};
+
 // ogl-only config, so not in VideoConfig.h
 struct VideoConfig
 {
@@ -59,6 +66,7 @@ struct VideoConfig
   bool bSupportsAniso;
   bool bSupportsBitfield;
   bool bSupportsTextureSubImage;
+  ES_FB_FETCH_TYPE SupportedFramebufferFetch;
 
   const char* gl_vendor;
   const char* gl_renderer;
diff --git a/Source/Core/VideoBackends/Software/SWmain.cpp b/Source/Core/VideoBackends/Software/SWmain.cpp
index 57c5096dfa..115f9a9509 100644
--- a/Source/Core/VideoBackends/Software/SWmain.cpp
+++ b/Source/Core/VideoBackends/Software/SWmain.cpp
@@ -73,6 +73,7 @@ void VideoSoftware::InitBackendInfo()
   g_Config.backend_info.bSupportsBPTCTextures = false;
   g_Config.backend_info.bSupportsCopyToVram = false;
   g_Config.backend_info.bForceCopyToRam = true;
+  g_Config.backend_info.bSupportsFramebufferFetch = false;
 
   // aamodes
   g_Config.backend_info.AAModes = {1};
diff --git a/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp b/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp
index 5447e7eea3..c55273a224 100644
--- a/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp
+++ b/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp
@@ -247,6 +247,7 @@ void VulkanContext::PopulateBackendInfo(VideoConfig* config)
   config->backend_info.bSupportsReversedDepthRange = false;  // No support yet due to driver bugs.
   config->backend_info.bSupportsCopyToVram = true;           // Assumed support.
   config->backend_info.bForceCopyToRam = false;
+  config->backend_info.bSupportsFramebufferFetch = false;
 }
 
 void VulkanContext::PopulateBackendInfoAdapters(VideoConfig* config, const GPUList& gpu_list)
diff --git a/Source/Core/VideoCommon/PixelShaderGen.cpp b/Source/Core/VideoCommon/PixelShaderGen.cpp
index 0ccfb09679..1a427b70d0 100644
--- a/Source/Core/VideoCommon/PixelShaderGen.cpp
+++ b/Source/Core/VideoCommon/PixelShaderGen.cpp
@@ -16,6 +16,7 @@
 #include "VideoCommon/DriverDetails.h"
 #include "VideoCommon/LightingShaderGen.h"
 #include "VideoCommon/NativeVertexFormat.h"
+#include "VideoCommon/RenderState.h"
 #include "VideoCommon/VertexLoaderManager.h"
 #include "VideoCommon/VideoCommon.h"
 #include "VideoCommon/VideoConfig.h"
@@ -319,6 +320,21 @@ PixelShaderUid GetPixelShaderUid()
   uid_data->fog_proj = bpmem.fog.c_proj_fsel.proj;
   uid_data->fog_RangeBaseEnabled = bpmem.fogRange.Base.Enabled;
 
+  BlendingState state = {};
+  state.Generate(bpmem);
+
+  if (state.usedualsrc && state.dstalpha && g_ActiveConfig.backend_info.bSupportsFramebufferFetch &&
+      !g_ActiveConfig.backend_info.bSupportsDualSourceBlend)
+  {
+    uid_data->blend_enable = state.blendenable;
+    uid_data->blend_src_factor = state.srcfactor;
+    uid_data->blend_src_factor_alpha = state.srcfactoralpha;
+    uid_data->blend_dst_factor = state.dstfactor;
+    uid_data->blend_dst_factor_alpha = state.dstfactoralpha;
+    uid_data->blend_subtract = state.subtract;
+    uid_data->blend_subtract_alpha = state.subtractAlpha;
+  }
+
   return out;
 }
 
@@ -447,6 +463,7 @@ static void WriteAlphaTest(ShaderCode& out, const pixel_shader_uid_data* uid_dat
 static void WriteFog(ShaderCode& out, const pixel_shader_uid_data* uid_data);
 static void WriteColor(ShaderCode& out, APIType api_type, const pixel_shader_uid_data* uid_data,
                        bool use_dual_source);
+static void WriteBlend(ShaderCode& out, const pixel_shader_uid_data* uid_data);
 
 ShaderCode GeneratePixelShaderCode(APIType ApiType, const ShaderHostConfig& host_config,
                                    const pixel_shader_uid_data* uid_data)
@@ -519,6 +536,8 @@ ShaderCode GeneratePixelShaderCode(APIType ApiType, const ShaderHostConfig& host
       host_config.backend_dual_source_blend &&
       (!DriverDetails::HasBug(DriverDetails::BUG_BROKEN_DUAL_SOURCE_BLENDING) ||
        uid_data->useDstAlpha);
+  const bool use_shader_blend =
+      !use_dual_source && (uid_data->useDstAlpha && host_config.backend_shader_framebuffer_fetch);
 
   if (ApiType == APIType::OpenGL || ApiType == APIType::Vulkan)
   {
@@ -535,6 +554,17 @@ ShaderCode GeneratePixelShaderCode(APIType ApiType, const ShaderHostConfig& host
         out.Write("FRAGMENT_OUTPUT_LOCATION_INDEXED(0, 1) out vec4 ocol1;\n");
       }
     }
+    else if (use_shader_blend)
+    {
+      if (DriverDetails::HasBug(DriverDetails::BUG_BROKEN_FRAGMENT_SHADER_INDEX_DECORATION))
+      {
+        out.Write("FRAGMENT_OUTPUT_LOCATION(0) FRAGMENT_INOUT vec4 ocol0;\n");
+      }
+      else
+      {
+        out.Write("FRAGMENT_OUTPUT_LOCATION_INDEXED(0, 0) FRAGMENT_INOUT vec4 ocol0;\n");
+      }
+    }
     else
     {
       out.Write("FRAGMENT_OUTPUT_LOCATION(0) out vec4 ocol0;\n");
@@ -575,6 +605,11 @@ ShaderCode GeneratePixelShaderCode(APIType ApiType, const ShaderHostConfig& host
 
     out.Write("void main()\n{\n");
     out.Write("\tfloat4 rawpos = gl_FragCoord;\n");
+    if (use_shader_blend)
+    {
+      // Store off a copy of the initial fb value for blending
+      out.Write("\tfloat4 initial_ocol0 = FB_FETCH_VALUE;\n");
+    }
   }
   else  // D3D
   {
@@ -710,7 +745,8 @@ ShaderCode GeneratePixelShaderCode(APIType ApiType, const ShaderHostConfig& host
   // testing result)
   if (uid_data->Pretest == AlphaTest::UNDETERMINED ||
       (uid_data->Pretest == AlphaTest::FAIL && uid_data->late_ztest))
-    WriteAlphaTest(out, uid_data, ApiType, uid_data->per_pixel_depth, use_dual_source);
+    WriteAlphaTest(out, uid_data, ApiType, uid_data->per_pixel_depth,
+                   use_dual_source || use_shader_blend);
 
   if (uid_data->zfreeze)
   {
@@ -793,7 +829,11 @@ ShaderCode GeneratePixelShaderCode(APIType ApiType, const ShaderHostConfig& host
   WriteFog(out, uid_data);
 
   // Write the color and alpha values to the framebuffer
-  WriteColor(out, ApiType, uid_data, use_dual_source);
+  // If using shader blend, we still use the separate alpha
+  WriteColor(out, ApiType, uid_data, use_dual_source || use_shader_blend);
+
+  if (use_shader_blend)
+    WriteBlend(out, uid_data);
 
   if (uid_data->bounding_box)
   {
@@ -1358,3 +1398,79 @@ static void WriteColor(ShaderCode& out, APIType api_type, const pixel_shader_uid
     }
   }
 }
+
+static void WriteBlend(ShaderCode& out, const pixel_shader_uid_data* uid_data)
+{
+  if (uid_data->blend_enable)
+  {
+    static const std::array<const char*, 8> blendSrcFactor = {
+        "float3(0,0,0);",                      // ZERO
+        "float3(1,1,1);",                      // ONE
+        "initial_ocol0.rgb;",                  // DSTCLR
+        "float3(1,1,1) - initial_ocol0.rgb;",  // INVDSTCLR
+        "ocol1.aaa;",                          // SRCALPHA
+        "float3(1,1,1) - ocol1.aaa;",          // INVSRCALPHA
+        "initial_ocol0.aaa;",                  // DSTALPHA
+        "float3(1,1,1) - initial_ocol0.aaa;",  // INVDSTALPHA
+    };
+    static const std::array<const char*, 8> blendSrcFactorAlpha = {
+        "0.0;",                    // ZERO
+        "1.0;",                    // ONE
+        "initial_ocol0.a;",        // DSTCLR
+        "1.0 - initial_ocol0.a;",  // INVDSTCLR
+        "ocol1.a;",                // SRCALPHA
+        "1.0 - ocol1.a;",          // INVSRCALPHA
+        "initial_ocol0.a;",        // DSTALPHA
+        "1.0 - initial_ocol0.a;",  // INVDSTALPHA
+    };
+    static const std::array<const char*, 8> blendDstFactor = {
+        "float3(0,0,0);",                      // ZERO
+        "float3(1,1,1);",                      // ONE
+        "ocol0.rgb;",                          // SRCCLR
+        "float3(1,1,1) - ocol0.rgb;",          // INVSRCCLR
+        "ocol1.aaa;",                          // SRCALHA
+        "float3(1,1,1) - ocol1.aaa;",          // INVSRCALPHA
+        "initial_ocol0.aaa;",                  // DSTALPHA
+        "float3(1,1,1) - initial_ocol0.aaa;",  // INVDSTALPHA
+    };
+    static const std::array<const char*, 8> blendDstFactorAlpha = {
+        "0.0;",                    // ZERO
+        "1.0;",                    // ONE
+        "ocol0.a;",                // SRCCLR
+        "1.0 - ocol0.a;",          // INVSRCCLR
+        "ocol1.a;",                // SRCALPHA
+        "1.0 - ocol1.a;",          // INVSRCALPHA
+        "initial_ocol0.a;",        // DSTALPHA
+        "1.0 - initial_ocol0.a;",  // INVDSTALPHA
+    };
+    out.Write("\tfloat4 blend_src;\n");
+    out.Write("\tblend_src.rgb = %s\n", blendSrcFactor[uid_data->blend_src_factor]);
+    out.Write("\tblend_src.a = %s\n", blendSrcFactorAlpha[uid_data->blend_src_factor_alpha]);
+    out.Write("\tfloat4 blend_dst;\n");
+    out.Write("\tblend_dst.rgb = %s\n", blendDstFactor[uid_data->blend_dst_factor]);
+    out.Write("\tblend_dst.a = %s\n", blendDstFactorAlpha[uid_data->blend_dst_factor_alpha]);
+
+    out.Write("\tfloat4 blend_result;\n");
+    if (uid_data->blend_subtract)
+    {
+      out.Write("\tblend_result.rgb = initial_ocol0.rgb * blend_dst.rgb - ocol0.rgb * "
+                "blend_src.rgb;\n");
+    }
+    else
+    {
+      out.Write(
+          "\tblend_result.rgb = initial_ocol0.rgb * blend_dst.rgb + ocol0.rgb * blend_src.rgb;\n");
+    }
+
+    if (uid_data->blend_subtract_alpha)
+      out.Write("\tblend_result.a = initial_ocol0.a * blend_dst.a - ocol0.a * blend_src.a;\n");
+    else
+      out.Write("\tblend_result.a = initial_ocol0.a * blend_dst.a + ocol0.a * blend_src.a;\n");
+  }
+  else
+  {
+    out.Write("\tfloat4 blend_result = ocol0;\n");
+  }
+
+  out.Write("\tocol0 = blend_result;\n");
+}
diff --git a/Source/Core/VideoCommon/PixelShaderGen.h b/Source/Core/VideoCommon/PixelShaderGen.h
index b480777c41..2e630e2e49 100644
--- a/Source/Core/VideoCommon/PixelShaderGen.h
+++ b/Source/Core/VideoCommon/PixelShaderGen.h
@@ -44,7 +44,13 @@ struct pixel_shader_uid_data
   u32 rgba6_format : 1;
   u32 dither : 1;
   u32 uint_output : 1;
-  u32 pad : 15;
+  u32 blend_enable : 1;            // Only used with shader_framebuffer_fetch blend
+  u32 blend_src_factor : 3;        // Only used with shader_framebuffer_fetch blend
+  u32 blend_src_factor_alpha : 3;  // Only used with shader_framebuffer_fetch blend
+  u32 blend_dst_factor : 3;        // Only used with shader_framebuffer_fetch blend
+  u32 blend_dst_factor_alpha : 3;  // Only used with shader_framebuffer_fetch blend
+  u32 blend_subtract : 1;          // Only used with shader_framebuffer_fetch blend
+  u32 blend_subtract_alpha : 1;    // Only used with shader_framebuffer_fetch blend
 
   u32 texMtxInfo_n_projection : 8;  // 8x1 bit
   u32 tevindref_bi0 : 3;
diff --git a/Source/Core/VideoCommon/ShaderGenCommon.cpp b/Source/Core/VideoCommon/ShaderGenCommon.cpp
index c6b29c8088..8cc7e54f5c 100644
--- a/Source/Core/VideoCommon/ShaderGenCommon.cpp
+++ b/Source/Core/VideoCommon/ShaderGenCommon.cpp
@@ -32,6 +32,7 @@ ShaderHostConfig ShaderHostConfig::GetCurrent()
   bits.backend_bitfield = g_ActiveConfig.backend_info.bSupportsBitfield;
   bits.backend_dynamic_sampler_indexing =
       g_ActiveConfig.backend_info.bSupportsDynamicSamplerIndexing;
+  bits.backend_shader_framebuffer_fetch = g_ActiveConfig.backend_info.bSupportsFramebufferFetch;
   return bits;
 }
 
@@ -68,9 +69,9 @@ std::string GetDiskShaderCacheFileName(APIType api_type, const char* type, bool
 
   if (include_host_config)
   {
-    // We're using 20 bits, so 5 hex characters.
+    // We're using 21 bits, so 6 hex characters.
     ShaderHostConfig host_config = ShaderHostConfig::GetCurrent();
-    filename += StringFromFormat("-%05X", host_config.bits);
+    filename += StringFromFormat("-%06X", host_config.bits);
   }
 
   filename += ".cache";
diff --git a/Source/Core/VideoCommon/ShaderGenCommon.h b/Source/Core/VideoCommon/ShaderGenCommon.h
index 3e3ef2eb13..98a30faa88 100644
--- a/Source/Core/VideoCommon/ShaderGenCommon.h
+++ b/Source/Core/VideoCommon/ShaderGenCommon.h
@@ -178,7 +178,8 @@ union ShaderHostConfig
     u32 backend_reversed_depth_range : 1;
     u32 backend_bitfield : 1;
     u32 backend_dynamic_sampler_indexing : 1;
-    u32 pad : 12;
+    u32 backend_shader_framebuffer_fetch : 1;
+    u32 pad : 11;
   };
 
   static ShaderHostConfig GetCurrent();
diff --git a/Source/Core/VideoCommon/VideoConfig.h b/Source/Core/VideoCommon/VideoConfig.h
index f7ece85a64..b472a2ab57 100644
--- a/Source/Core/VideoCommon/VideoConfig.h
+++ b/Source/Core/VideoCommon/VideoConfig.h
@@ -227,6 +227,7 @@ struct VideoConfig final
     bool bSupportsBitfield;                // Needed by UberShaders, so must stay in VideoCommon
     bool bSupportsDynamicSamplerIndexing;  // Needed by UberShaders, so must stay in VideoCommon
     bool bSupportsBPTCTextures;
+    bool bSupportsFramebufferFetch;  // Used as an alternative to dual-source blend on GLES
   } backend_info;
 
   // Utility