diff --git a/Source/Core/Core/ConfigManager.cpp b/Source/Core/Core/ConfigManager.cpp
index 7eefe9b945..21d722290e 100644
--- a/Source/Core/Core/ConfigManager.cpp
+++ b/Source/Core/Core/ConfigManager.cpp
@@ -211,7 +211,7 @@ void SConfig::OnNewTitleLoad(const Core::CPUThreadGuard& guard)
   }
   CBoot::LoadMapFromFilename(guard, ppc_symbol_db);
   HLE::Reload(system);
-  PatchEngine::Reload();
+  PatchEngine::Reload(system);
   HiresTexture::Update();
   WC24PatchEngine::Reload();
 }
diff --git a/Source/Core/Core/PatchEngine.cpp b/Source/Core/Core/PatchEngine.cpp
index 16be2960ba..9880977710 100644
--- a/Source/Core/Core/PatchEngine.cpp
+++ b/Source/Core/Core/PatchEngine.cpp
@@ -295,6 +295,13 @@ void RemoveMemoryPatch(std::size_t index)
   std::erase(s_on_frame_memory, index);
 }
 
+static void ApplyStartupPatches(Core::System& system)
+{
+  ASSERT(Core::IsCPUThread());
+  Core::CPUThreadGuard guard(system);
+  ApplyPatches(guard, s_on_frame);
+}
+
 bool ApplyFramePatches(Core::System& system)
 {
   const auto& ppc_state = system.GetPPCState();
@@ -332,10 +339,11 @@ void Shutdown()
   Gecko::Shutdown();
 }
 
-void Reload()
+void Reload(Core::System& system)
 {
   Shutdown();
   LoadPatches();
+  ApplyStartupPatches(system);
 }
 
 }  // namespace PatchEngine
diff --git a/Source/Core/Core/PatchEngine.h b/Source/Core/Core/PatchEngine.h
index 69ec0c9bb7..32e4ec93db 100644
--- a/Source/Core/Core/PatchEngine.h
+++ b/Source/Core/Core/PatchEngine.h
@@ -61,7 +61,7 @@ void RemoveMemoryPatch(std::size_t index);
 
 bool ApplyFramePatches(Core::System& system);
 void Shutdown();
-void Reload();
+void Reload(Core::System& system);
 
 inline int GetPatchTypeCharLength(PatchType type)
 {