diff --git a/Source/Core/AudioCommon/Mixer.cpp b/Source/Core/AudioCommon/Mixer.cpp
index 6888d9520b..f6bebb60cc 100644
--- a/Source/Core/AudioCommon/Mixer.cpp
+++ b/Source/Core/AudioCommon/Mixer.cpp
@@ -35,11 +35,15 @@ Mixer::Mixer(unsigned int BackendSampleRate)
       m_surround_decoder(BackendSampleRate,
                          DPL2QualityToFrameBlockSize(Config::Get(Config::MAIN_DPL2_QUALITY)))
 {
+  m_config_changed_callback_id = Config::AddConfigChangedCallback([this] { RefreshConfig(); });
+  RefreshConfig();
+
   INFO_LOG_FMT(AUDIO_INTERFACE, "Mixer is initialized");
 }
 
 Mixer::~Mixer()
 {
+  Config::RemoveConfigChangedCallback(m_config_changed_callback_id);
 }
 
 void Mixer::DoState(PointerWrap& p)
@@ -53,7 +57,8 @@ void Mixer::DoState(PointerWrap& p)
 
 // Executed from sound stream thread
 unsigned int Mixer::MixerFifo::Mix(short* samples, unsigned int numSamples,
-                                   bool consider_framelimit)
+                                   bool consider_framelimit, float emulationspeed,
+                                   int timing_variance)
 {
   unsigned int currentSample = 0;
 
@@ -71,13 +76,12 @@ unsigned int Mixer::MixerFifo::Mix(short* samples, unsigned int numSamples,
   // advance indexR with sample position
   // remember fractional offset
 
-  float emulationspeed = SConfig::GetInstance().m_EmulationSpeed;
   float aid_sample_rate = static_cast<float>(m_input_sample_rate);
   if (consider_framelimit && emulationspeed > 0.0f)
   {
     float numLeft = static_cast<float>(((indexW - indexR) & INDEX_MASK) / 2);
 
-    u32 low_waterwark = m_input_sample_rate * SConfig::GetInstance().iTimingVariance / 1000;
+    u32 low_waterwark = m_input_sample_rate * timing_variance / 1000;
     low_waterwark = std::min(low_waterwark, MAX_SAMPLES / 2);
 
     m_numLeftI = (numLeft + m_numLeftI * (CONTROL_AVG - 1)) / CONTROL_AVG;
@@ -154,18 +158,26 @@ unsigned int Mixer::Mix(short* samples, unsigned int num_samples)
 
   memset(samples, 0, num_samples * 2 * sizeof(short));
 
-  if (Config::Get(Config::MAIN_AUDIO_STRETCH))
+  const float emulation_speed = m_config_emulation_speed;
+  const int timing_variance = m_config_timing_variance;
+  if (m_config_audio_stretch)
   {
     unsigned int available_samples =
         std::min(m_dma_mixer.AvailableSamples(), m_streaming_mixer.AvailableSamples());
 
     m_scratch_buffer.fill(0);
 
-    m_dma_mixer.Mix(m_scratch_buffer.data(), available_samples, false);
-    m_streaming_mixer.Mix(m_scratch_buffer.data(), available_samples, false);
-    m_wiimote_speaker_mixer.Mix(m_scratch_buffer.data(), available_samples, false);
+    m_dma_mixer.Mix(m_scratch_buffer.data(), available_samples, false, emulation_speed,
+                    timing_variance);
+    m_streaming_mixer.Mix(m_scratch_buffer.data(), available_samples, false, emulation_speed,
+                          timing_variance);
+    m_wiimote_speaker_mixer.Mix(m_scratch_buffer.data(), available_samples, false, emulation_speed,
+                                timing_variance);
     for (auto& mixer : m_gba_mixers)
-      mixer.Mix(m_scratch_buffer.data(), available_samples, false);
+    {
+      mixer.Mix(m_scratch_buffer.data(), available_samples, false, emulation_speed,
+                timing_variance);
+    }
 
     if (!m_is_stretching)
     {
@@ -177,11 +189,11 @@ unsigned int Mixer::Mix(short* samples, unsigned int num_samples)
   }
   else
   {
-    m_dma_mixer.Mix(samples, num_samples, true);
-    m_streaming_mixer.Mix(samples, num_samples, true);
-    m_wiimote_speaker_mixer.Mix(samples, num_samples, true);
+    m_dma_mixer.Mix(samples, num_samples, true, emulation_speed, timing_variance);
+    m_streaming_mixer.Mix(samples, num_samples, true, emulation_speed, timing_variance);
+    m_wiimote_speaker_mixer.Mix(samples, num_samples, true, emulation_speed, timing_variance);
     for (auto& mixer : m_gba_mixers)
-      mixer.Mix(samples, num_samples, true);
+      mixer.Mix(samples, num_samples, true, emulation_speed, timing_variance);
     m_is_stretching = false;
   }
 
@@ -385,6 +397,13 @@ void Mixer::StopLogDSPAudio()
   }
 }
 
+void Mixer::RefreshConfig()
+{
+  m_config_emulation_speed = Config::Get(Config::MAIN_EMULATION_SPEED);
+  m_config_timing_variance = Config::Get(Config::MAIN_TIMING_VARIANCE);
+  m_config_audio_stretch = Config::Get(Config::MAIN_AUDIO_STRETCH);
+}
+
 void Mixer::MixerFifo::DoState(PointerWrap& p)
 {
   p.Do(m_input_sample_rate);
diff --git a/Source/Core/AudioCommon/Mixer.h b/Source/Core/AudioCommon/Mixer.h
index b47f7b204c..0cf25810fb 100644
--- a/Source/Core/AudioCommon/Mixer.h
+++ b/Source/Core/AudioCommon/Mixer.h
@@ -69,7 +69,8 @@ private:
     }
     void DoState(PointerWrap& p);
     void PushSamples(const short* samples, unsigned int num_samples);
-    unsigned int Mix(short* samples, unsigned int numSamples, bool consider_framelimit = true);
+    unsigned int Mix(short* samples, unsigned int numSamples, bool consider_framelimit,
+                     float emulationspeed, int timing_variance);
     void SetInputSampleRate(unsigned int rate);
     unsigned int GetInputSampleRate() const;
     void SetVolume(unsigned int lvolume, unsigned int rvolume);
@@ -89,6 +90,8 @@ private:
     u32 m_frac = 0;
   };
 
+  void RefreshConfig();
+
   MixerFifo m_dma_mixer{this, 32000, false};
   MixerFifo m_streaming_mixer{this, 48000, false};
   MixerFifo m_wiimote_speaker_mixer{this, 3000, true};
@@ -109,4 +112,10 @@ private:
 
   // Current rate of emulation (1.0 = 100% speed)
   std::atomic<float> m_speed{0.0f};
+
+  float m_config_emulation_speed;
+  int m_config_timing_variance;
+  bool m_config_audio_stretch;
+
+  size_t m_config_changed_callback_id;
 };
diff --git a/Source/Core/Core/BootManager.cpp b/Source/Core/Core/BootManager.cpp
index acc46a7f16..5f72002545 100644
--- a/Source/Core/Core/BootManager.cpp
+++ b/Source/Core/Core/BootManager.cpp
@@ -64,7 +64,6 @@ public:
 
   // These store if the relevant setting should be reset back later (true) or if it should be left
   // alone on restore (false)
-  bool bSetEmulationSpeed = false;
   bool bSetVolume = false;
   std::array<bool, MAX_BBMOTES> bSetWiimoteSource{};
   std::array<bool, SerialInterface::MAX_SI_CHANNELS> bSetPads{};
@@ -73,16 +72,11 @@ public:
 private:
   bool valid = false;
   bool bCPUThread = false;
-  bool bSyncGPUOnSkipIdleHack = false;
   bool bMMU = false;
-  bool bDisableICache = false;
   bool bSyncGPU = false;
   int iSyncGpuMaxDistance = 0;
   int iSyncGpuMinDistance = 0;
   float fSyncGpuOverclock = 0;
-  bool bFastDiscSpeed = false;
-  float m_EmulationSpeed = 0;
-  std::string m_strGPUDeterminismMode;
   std::array<WiimoteSource, MAX_BBMOTES> iWiimoteSource{};
   std::array<SerialInterface::SIDevices, SerialInterface::MAX_SI_CHANNELS> Pads{};
   std::array<ExpansionInterface::TEXIDevices, ExpansionInterface::MAX_EXI_CHANNELS> m_EXIDevice{};
@@ -93,16 +87,11 @@ void ConfigCache::SaveConfig(const SConfig& config)
   valid = true;
 
   bCPUThread = config.bCPUThread;
-  bSyncGPUOnSkipIdleHack = config.bSyncGPUOnSkipIdleHack;
-  bDisableICache = config.bDisableICache;
   bMMU = config.bMMU;
   bSyncGPU = config.bSyncGPU;
   iSyncGpuMaxDistance = config.iSyncGpuMaxDistance;
   iSyncGpuMinDistance = config.iSyncGpuMinDistance;
   fSyncGpuOverclock = config.fSyncGpuOverclock;
-  bFastDiscSpeed = config.bFastDiscSpeed;
-  m_EmulationSpeed = config.m_EmulationSpeed;
-  m_strGPUDeterminismMode = config.m_strGPUDeterminismMode;
 
   for (int i = 0; i != MAX_BBMOTES; ++i)
     iWiimoteSource[i] = WiimoteCommon::GetSource(i);
@@ -110,7 +99,6 @@ void ConfigCache::SaveConfig(const SConfig& config)
   std::copy(std::begin(config.m_SIDevice), std::end(config.m_SIDevice), std::begin(Pads));
   std::copy(std::begin(config.m_EXIDevice), std::end(config.m_EXIDevice), std::begin(m_EXIDevice));
 
-  bSetEmulationSpeed = false;
   bSetVolume = false;
   bSetWiimoteSource.fill(false);
   bSetPads.fill(false);
@@ -125,14 +113,11 @@ void ConfigCache::RestoreConfig(SConfig* config)
   valid = false;
 
   config->bCPUThread = bCPUThread;
-  config->bSyncGPUOnSkipIdleHack = bSyncGPUOnSkipIdleHack;
-  config->bDisableICache = bDisableICache;
   config->bMMU = bMMU;
   config->bSyncGPU = bSyncGPU;
   config->iSyncGpuMaxDistance = iSyncGpuMaxDistance;
   config->iSyncGpuMinDistance = iSyncGpuMinDistance;
   config->fSyncGpuOverclock = fSyncGpuOverclock;
-  config->bFastDiscSpeed = bFastDiscSpeed;
 
   // Only change these back if they were actually set by game ini, since they can be changed while a
   // game is running.
@@ -151,38 +136,15 @@ void ConfigCache::RestoreConfig(SConfig* config)
       config->m_SIDevice[i] = Pads[i];
   }
 
-  if (bSetEmulationSpeed)
-    config->m_EmulationSpeed = m_EmulationSpeed;
-
   for (unsigned int i = 0; i < ExpansionInterface::MAX_EXI_CHANNELS; ++i)
   {
     if (bSetEXIDevice[i])
       config->m_EXIDevice[i] = m_EXIDevice[i];
   }
-
-  config->m_strGPUDeterminismMode = m_strGPUDeterminismMode;
 }
 
 static ConfigCache config_cache;
 
-void SetEmulationSpeedReset(bool value)
-{
-  config_cache.bSetEmulationSpeed = value;
-}
-
-static GPUDeterminismMode ParseGPUDeterminismMode(const std::string& mode)
-{
-  if (mode == "auto")
-    return GPUDeterminismMode::Auto;
-  if (mode == "none")
-    return GPUDeterminismMode::Disabled;
-  if (mode == "fake-completion")
-    return GPUDeterminismMode::FakeCompletion;
-
-  NOTICE_LOG_FMT(BOOT, "Unknown GPU determinism mode {}", mode);
-  return GPUDeterminismMode::Auto;
-}
-
 // Boot the ISO or file
 bool BootCore(std::unique_ptr<BootParameters> boot, const WindowSystemInfo& wsi)
 {
@@ -206,17 +168,8 @@ bool BootCore(std::unique_ptr<BootParameters> boot, const WindowSystemInfo& wsi)
     IniFile::Section* controls_section = game_ini.GetOrCreateSection("Controls");
 
     core_section->Get("CPUThread", &StartUp.bCPUThread, StartUp.bCPUThread);
-    core_section->Get("SyncOnSkipIdle", &StartUp.bSyncGPUOnSkipIdleHack,
-                      StartUp.bSyncGPUOnSkipIdleHack);
-    core_section->Get("DisableICache", &StartUp.bDisableICache, StartUp.bDisableICache);
     core_section->Get("MMU", &StartUp.bMMU, StartUp.bMMU);
     core_section->Get("SyncGPU", &StartUp.bSyncGPU, StartUp.bSyncGPU);
-    core_section->Get("FastDiscSpeed", &StartUp.bFastDiscSpeed, StartUp.bFastDiscSpeed);
-    if (core_section->Get("EmulationSpeed", &StartUp.m_EmulationSpeed, StartUp.m_EmulationSpeed))
-      config_cache.bSetEmulationSpeed = true;
-
-    core_section->Get("GPUDeterminismMode", &StartUp.m_strGPUDeterminismMode,
-                      StartUp.m_strGPUDeterminismMode);
 
     for (unsigned int i = 0; i < SerialInterface::MAX_SI_CHANNELS; ++i)
     {
@@ -256,14 +209,11 @@ bool BootCore(std::unique_ptr<BootParameters> boot, const WindowSystemInfo& wsi)
     }
   }
 
-  StartUp.m_GPUDeterminismMode = ParseGPUDeterminismMode(StartUp.m_strGPUDeterminismMode);
-
   // Movie settings
   if (Movie::IsPlayingInput() && Movie::IsConfigSaved())
   {
     // TODO: remove this once ConfigManager starts using OnionConfig.
     StartUp.bCPUThread = Config::Get(Config::MAIN_CPU_THREAD);
-    StartUp.bFastDiscSpeed = Config::Get(Config::MAIN_FAST_DISC_SPEED);
     StartUp.bSyncGPU = Config::Get(Config::MAIN_SYNC_GPU);
     for (int i = 0; i < 2; ++i)
     {
@@ -293,17 +243,11 @@ bool BootCore(std::unique_ptr<BootParameters> boot, const WindowSystemInfo& wsi)
     config_cache.bSetEXIDevice[0] = true;
     config_cache.bSetEXIDevice[1] = true;
     config_cache.bSetEXIDevice[2] = true;
-    StartUp.bDisableICache = netplay_settings.m_DisableICache;
-    StartUp.bSyncGPUOnSkipIdleHack = netplay_settings.m_SyncOnSkipIdle;
     StartUp.bSyncGPU = netplay_settings.m_SyncGPU;
     StartUp.iSyncGpuMaxDistance = netplay_settings.m_SyncGpuMaxDistance;
     StartUp.iSyncGpuMinDistance = netplay_settings.m_SyncGpuMinDistance;
     StartUp.fSyncGpuOverclock = netplay_settings.m_SyncGpuOverclock;
-    StartUp.bFastDiscSpeed = netplay_settings.m_FastDiscSpeed;
     StartUp.bMMU = netplay_settings.m_MMU;
-    StartUp.bFastmem = netplay_settings.m_Fastmem;
-    if (netplay_settings.m_HostInputAuthority && !netplay_settings.m_IsHosting)
-      config_cache.bSetEmulationSpeed = true;
   }
   else
   {
@@ -355,7 +299,7 @@ bool BootCore(std::unique_ptr<BootParameters> boot, const WindowSystemInfo& wsi)
 
   // Disable loading time emulation for Riivolution-patched games until we have proper emulation.
   if (!boot->riivolution_patches.empty())
-    StartUp.bFastDiscSpeed = true;
+    Config::SetCurrent(Config::MAIN_FAST_DISC_SPEED, true);
 
   Core::UpdateWantDeterminism(/*initial*/ true);
 
diff --git a/Source/Core/Core/BootManager.h b/Source/Core/Core/BootManager.h
index cdc790322e..10474c5f3f 100644
--- a/Source/Core/Core/BootManager.h
+++ b/Source/Core/Core/BootManager.h
@@ -11,7 +11,6 @@ struct WindowSystemInfo;
 namespace BootManager
 {
 bool BootCore(std::unique_ptr<BootParameters> parameters, const WindowSystemInfo& wsi);
-void SetEmulationSpeedReset(bool value);
 
 // Synchronise Dolphin's configuration with the SYSCONF (which may have changed during emulation),
 // and restore settings that were overriden by per-game INIs or for some other reason.
diff --git a/Source/Core/Core/Config/MainSettings.cpp b/Source/Core/Core/Config/MainSettings.cpp
index 4e17de9868..7f8c132c58 100644
--- a/Source/Core/Core/Config/MainSettings.cpp
+++ b/Source/Core/Core/Config/MainSettings.cpp
@@ -10,6 +10,7 @@
 #include "AudioCommon/AudioCommon.h"
 #include "Common/CommonPaths.h"
 #include "Common/Config/Config.h"
+#include "Common/Logging/Log.h"
 #include "Common/MathUtil.h"
 #include "Common/StringUtil.h"
 #include "Common/Version.h"
@@ -96,6 +97,8 @@ const Info<bool> MAIN_WII_KEYBOARD{{System::Main, "Core", "WiiKeyboard"}, false}
 const Info<bool> MAIN_WIIMOTE_CONTINUOUS_SCANNING{
     {System::Main, "Core", "WiimoteContinuousScanning"}, false};
 const Info<bool> MAIN_WIIMOTE_ENABLE_SPEAKER{{System::Main, "Core", "WiimoteEnableSpeaker"}, false};
+const Info<bool> MAIN_CONNECT_WIIMOTES_FOR_CONTROLLER_INTERFACE{
+    {System::Main, "Core", "WiimoteControllerInterface"}, false};
 const Info<bool> MAIN_MMU{{System::Main, "Core", "MMU"}, false};
 const Info<int> MAIN_BB_DUMP_PORT{{System::Main, "Core", "BBDumpPort"}, -1};
 const Info<bool> MAIN_SYNC_GPU{{System::Main, "Core", "SyncGPU"}, false};
@@ -118,8 +121,24 @@ const Info<u32> MAIN_MEM1_SIZE{{System::Main, "Core", "MEM1Size"}, Memory::MEM1_
 const Info<u32> MAIN_MEM2_SIZE{{System::Main, "Core", "MEM2Size"}, Memory::MEM2_SIZE_RETAIL};
 const Info<std::string> MAIN_GFX_BACKEND{{System::Main, "Core", "GFXBackend"},
                                          VideoBackendBase::GetDefaultBackendName()};
+
 const Info<std::string> MAIN_GPU_DETERMINISM_MODE{{System::Main, "Core", "GPUDeterminismMode"},
                                                   "auto"};
+
+GPUDeterminismMode GetGPUDeterminismMode()
+{
+  auto mode = Config::Get(Config::MAIN_GPU_DETERMINISM_MODE);
+  if (mode == "auto")
+    return GPUDeterminismMode::Auto;
+  if (mode == "none")
+    return GPUDeterminismMode::Disabled;
+  if (mode == "fake-completion")
+    return GPUDeterminismMode::FakeCompletion;
+
+  NOTICE_LOG_FMT(CORE, "Unknown GPU determinism mode {}", mode);
+  return GPUDeterminismMode::Auto;
+}
+
 const Info<std::string> MAIN_PERF_MAP_DIR{{System::Main, "Core", "PerfMapDir"}, ""};
 const Info<bool> MAIN_CUSTOM_RTC_ENABLE{{System::Main, "Core", "EnableCustomRTC"}, false};
 // Default to seconds between 1.1.1970 and 1.1.2000
diff --git a/Source/Core/Core/Config/MainSettings.h b/Source/Core/Core/Config/MainSettings.h
index 910b7e8ee0..0e5b0fdbe9 100644
--- a/Source/Core/Core/Config/MainSettings.h
+++ b/Source/Core/Core/Config/MainSettings.h
@@ -72,6 +72,7 @@ extern const Info<bool> MAIN_WII_SD_CARD;
 extern const Info<bool> MAIN_WII_KEYBOARD;
 extern const Info<bool> MAIN_WIIMOTE_CONTINUOUS_SCANNING;
 extern const Info<bool> MAIN_WIIMOTE_ENABLE_SPEAKER;
+extern const Info<bool> MAIN_CONNECT_WIIMOTES_FOR_CONTROLLER_INTERFACE;
 extern const Info<bool> MAIN_MMU;
 extern const Info<int> MAIN_BB_DUMP_PORT;
 extern const Info<bool> MAIN_SYNC_GPU;
@@ -93,7 +94,18 @@ extern const Info<u32> MAIN_MEM1_SIZE;
 extern const Info<u32> MAIN_MEM2_SIZE;
 // Should really be part of System::GFX, but again, we're stuck with past mistakes.
 extern const Info<std::string> MAIN_GFX_BACKEND;
+
+enum class GPUDeterminismMode
+{
+  Auto,
+  Disabled,
+  // This is currently the only mode.  There will probably be at least
+  // one more at some point.
+  FakeCompletion,
+};
 extern const Info<std::string> MAIN_GPU_DETERMINISM_MODE;
+GPUDeterminismMode GetGPUDeterminismMode();
+
 extern const Info<std::string> MAIN_PERF_MAP_DIR;
 extern const Info<bool> MAIN_CUSTOM_RTC_ENABLE;
 extern const Info<u32> MAIN_CUSTOM_RTC_VALUE;
diff --git a/Source/Core/Core/ConfigLoaders/IsSettingSaveable.cpp b/Source/Core/Core/ConfigLoaders/IsSettingSaveable.cpp
index a41ef76b09..9859fb977d 100644
--- a/Source/Core/Core/ConfigLoaders/IsSettingSaveable.cpp
+++ b/Source/Core/Core/ConfigLoaders/IsSettingSaveable.cpp
@@ -97,6 +97,19 @@ bool IsSettingSaveable(const Config::Location& config_location)
       &Config::GetInfoForSimulateKonga(1).GetLocation(),
       &Config::GetInfoForSimulateKonga(2).GetLocation(),
       &Config::GetInfoForSimulateKonga(3).GetLocation(),
+      &Config::MAIN_EMULATION_SPEED.GetLocation(),
+      &Config::MAIN_PERF_MAP_DIR.GetLocation(),
+      &Config::MAIN_GPU_DETERMINISM_MODE.GetLocation(),
+      &Config::MAIN_DISABLE_ICACHE.GetLocation(),
+      &Config::MAIN_FAST_DISC_SPEED.GetLocation(),
+      &Config::MAIN_SYNC_ON_SKIP_IDLE.GetLocation(),
+      &Config::MAIN_FASTMEM.GetLocation(),
+      &Config::MAIN_TIMING_VARIANCE.GetLocation(),
+      &Config::MAIN_WII_SD_CARD.GetLocation(),
+      &Config::MAIN_WII_KEYBOARD.GetLocation(),
+      &Config::MAIN_WIIMOTE_CONTINUOUS_SCANNING.GetLocation(),
+      &Config::MAIN_WIIMOTE_ENABLE_SPEAKER.GetLocation(),
+      &Config::MAIN_CONNECT_WIIMOTES_FOR_CONTROLLER_INTERFACE.GetLocation(),
 
       // UI.General
 
diff --git a/Source/Core/Core/ConfigManager.cpp b/Source/Core/Core/ConfigManager.cpp
index c4b9cb079c..cdd691f259 100644
--- a/Source/Core/Core/ConfigManager.cpp
+++ b/Source/Core/Core/ConfigManager.cpp
@@ -99,10 +99,7 @@ void SConfig::SaveCoreSettings(IniFile& ini)
 {
   IniFile::Section* core = ini.GetOrCreateSection("Core");
 
-  core->Set("TimingVariance", iTimingVariance);
-  core->Set("Fastmem", bFastmem);
   core->Set("CPUThread", bCPUThread);
-  core->Set("SyncOnSkipIdle", bSyncGPUOnSkipIdleHack);
   core->Set("SyncGPU", bSyncGPU);
   core->Set("SyncGpuMaxDistance", iSyncGpuMaxDistance);
   core->Set("SyncGpuMinDistance", iSyncGpuMinDistance);
@@ -114,15 +111,7 @@ void SConfig::SaveCoreSettings(IniFile& ini)
   {
     core->Set(fmt::format("SIDevice{}", i), m_SIDevice[i]);
   }
-  core->Set("WiiSDCard", m_WiiSDCard);
-  core->Set("WiiKeyboard", m_WiiKeyboard);
-  core->Set("WiimoteContinuousScanning", m_WiimoteContinuousScanning);
-  core->Set("WiimoteEnableSpeaker", m_WiimoteEnableSpeaker);
-  core->Set("WiimoteControllerInterface", connect_wiimotes_for_ciface);
   core->Set("MMU", bMMU);
-  core->Set("EmulationSpeed", m_EmulationSpeed);
-  core->Set("GPUDeterminismMode", m_strGPUDeterminismMode);
-  core->Set("PerfMapDir", m_perfDir);
 }
 
 void SConfig::LoadSettings()
@@ -140,10 +129,7 @@ void SConfig::LoadCoreSettings(IniFile& ini)
 {
   IniFile::Section* core = ini.GetOrCreateSection("Core");
 
-  core->Get("Fastmem", &bFastmem, true);
-  core->Get("TimingVariance", &iTimingVariance, 40);
   core->Get("CPUThread", &bCPUThread, true);
-  core->Get("SyncOnSkipIdle", &bSyncGPUOnSkipIdleHack, true);
   core->Get("SlotA", (int*)&m_EXIDevice[0], ExpansionInterface::EXIDEVICE_MEMORYCARDFOLDER);
   core->Get("SlotB", (int*)&m_EXIDevice[1], ExpansionInterface::EXIDEVICE_NONE);
   core->Get("SerialPort1", (int*)&m_EXIDevice[2], ExpansionInterface::EXIDEVICE_NONE);
@@ -152,22 +138,12 @@ void SConfig::LoadCoreSettings(IniFile& ini)
     core->Get(fmt::format("SIDevice{}", i), &m_SIDevice[i],
               (i == 0) ? SerialInterface::SIDEVICE_GC_CONTROLLER : SerialInterface::SIDEVICE_NONE);
   }
-  core->Get("WiiSDCard", &m_WiiSDCard, true);
-  core->Get("WiiKeyboard", &m_WiiKeyboard, false);
-  core->Get("WiimoteContinuousScanning", &m_WiimoteContinuousScanning, false);
-  core->Get("WiimoteEnableSpeaker", &m_WiimoteEnableSpeaker, false);
-  core->Get("WiimoteControllerInterface", &connect_wiimotes_for_ciface, false);
   core->Get("MMU", &bMMU, bMMU);
   core->Get("BBDumpPort", &iBBDumpPort, -1);
   core->Get("SyncGPU", &bSyncGPU, false);
   core->Get("SyncGpuMaxDistance", &iSyncGpuMaxDistance, 200000);
   core->Get("SyncGpuMinDistance", &iSyncGpuMinDistance, -200000);
   core->Get("SyncGpuOverclock", &fSyncGpuOverclock, 1.0f);
-  core->Get("FastDiscSpeed", &bFastDiscSpeed, false);
-  core->Get("DisableICache", &bDisableICache, false);
-  core->Get("EmulationSpeed", &m_EmulationSpeed, 1.0f);
-  core->Get("GPUDeterminismMode", &m_strGPUDeterminismMode, "auto");
-  core->Get("PerfMapDir", &m_perfDir, "");
 }
 
 void SConfig::ResetRunningGameMetadata()
@@ -283,15 +259,10 @@ void SConfig::LoadDefaults()
   bAutomaticStart = false;
   bBootToPause = false;
 
-  iTimingVariance = 40;
   bCPUThread = false;
-  bSyncGPUOnSkipIdleHack = true;
-  bFastmem = true;
-  bDisableICache = false;
   bMMU = false;
   iBBDumpPort = -1;
   bSyncGPU = false;
-  bFastDiscSpeed = false;
   bWii = false;
 
   ResetRunningGameMetadata();
diff --git a/Source/Core/Core/ConfigManager.h b/Source/Core/Core/ConfigManager.h
index 46804f3172..51dfc2b85e 100644
--- a/Source/Core/Core/ConfigManager.h
+++ b/Source/Core/Core/ConfigManager.h
@@ -47,24 +47,8 @@ enum SIDevices : int;
 
 struct BootParameters;
 
-enum class GPUDeterminismMode
-{
-  Auto,
-  Disabled,
-  // This is currently the only mode.  There will probably be at least
-  // one more at some point.
-  FakeCompletion,
-};
-
 struct SConfig
 {
-  // Wii Devices
-  bool m_WiiSDCard;
-  bool m_WiiKeyboard;
-  bool m_WiimoteContinuousScanning;
-  bool m_WiimoteEnableSpeaker;
-  bool connect_wiimotes_for_ciface;
-
   // Settings
   bool bAutomaticStart = false;
   bool bBootToPause = false;
@@ -72,17 +56,11 @@ struct SConfig
   bool bJITNoBlockCache = false;
   bool bJITNoBlockLinking = false;
 
-  bool bFastmem;
-  bool bDisableICache = false;
-
-  int iTimingVariance = 40;  // in milli secounds
   bool bCPUThread = true;
-  bool bSyncGPUOnSkipIdleHack = true;
   bool bCopyWiiSaveNetplay = true;
 
   bool bMMU = false;
   int iBBDumpPort = 0;
-  bool bFastDiscSpeed = false;
 
   bool bSyncGPU = false;
   int iSyncGpuMaxDistance;
@@ -94,17 +72,10 @@ struct SConfig
 
   DiscIO::Region m_region;
 
-  std::string m_strGPUDeterminismMode;
-
-  // set based on the string version
-  GPUDeterminismMode m_GPUDeterminismMode;
-
   // files
   std::string m_strBootROM;
   std::string m_strSRAM;
 
-  std::string m_perfDir;
-
   std::string m_debugger_game_id;
   // TODO: remove this as soon as the ticket view hack in IOS/ES/Views is dropped.
   bool m_disc_booted_from_game_list = false;
@@ -146,8 +117,6 @@ struct SConfig
   ExpansionInterface::TEXIDevices m_EXIDevice[3];
   SerialInterface::SIDevices m_SIDevice[4];
 
-  float m_EmulationSpeed;
-
   SConfig(const SConfig&) = delete;
   SConfig& operator=(const SConfig&) = delete;
   SConfig(SConfig&&) = delete;
diff --git a/Source/Core/Core/Core.cpp b/Source/Core/Core/Core.cpp
index a5ae7784b6..df575b431f 100644
--- a/Source/Core/Core/Core.cpp
+++ b/Source/Core/Core/Core.cpp
@@ -348,7 +348,8 @@ static void CpuThread(const std::optional<std::string>& savestate_path, bool del
   static_cast<void>(IDCache::GetEnvForThread());
 #endif
 
-  if (_CoreParameter.bFastmem)
+  const bool fastmem_enabled = Config::Get(Config::MAIN_FASTMEM);
+  if (fastmem_enabled)
     EMM::InstallExceptionHandler();  // Let's run under memory watch
 
 #ifdef USE_MEMORYWATCHER
@@ -396,7 +397,7 @@ static void CpuThread(const std::optional<std::string>& savestate_path, bool del
 
   s_is_started = false;
 
-  if (_CoreParameter.bFastmem)
+  if (fastmem_enabled)
     EMM::UninstallExceptionHandler();
 
   if (GDBStub::IsActive())
diff --git a/Source/Core/Core/CoreTiming.cpp b/Source/Core/Core/CoreTiming.cpp
index f850c726d6..e90d367c5e 100644
--- a/Source/Core/Core/CoreTiming.cpp
+++ b/Source/Core/Core/CoreTiming.cpp
@@ -17,7 +17,6 @@
 #include "Common/SPSCQueue.h"
 
 #include "Core/Config/MainSettings.h"
-#include "Core/ConfigManager.h"
 #include "Core/Core.h"
 #include "Core/PowerPC/PowerPC.h"
 
@@ -81,6 +80,7 @@ static EventType* s_ev_lost = nullptr;
 static size_t s_registered_config_callback_id;
 static float s_config_OC_factor;
 static float s_config_OC_inv_factor;
+static bool s_config_sync_on_skip_idle;
 
 static void EmptyTimedCallback(u64 userdata, s64 cyclesLate)
 {
@@ -161,6 +161,7 @@ void RefreshConfig()
   s_config_OC_factor =
       Config::Get(Config::MAIN_OVERCLOCK_ENABLE) ? Config::Get(Config::MAIN_OVERCLOCK) : 1.0f;
   s_config_OC_inv_factor = 1.0f / s_config_OC_factor;
+  s_config_sync_on_skip_idle = Config::Get(Config::MAIN_SYNC_ON_SKIP_IDLE);
 }
 
 void DoState(PointerWrap& p)
@@ -388,7 +389,7 @@ void AdjustEventQueueTimes(u32 new_ppc_clock, u32 old_ppc_clock)
 
 void Idle()
 {
-  if (SConfig::GetInstance().bSyncGPUOnSkipIdleHack)
+  if (s_config_sync_on_skip_idle)
   {
     // When the FIFO is processing data we must not advance because in this way
     // the VI will be desynchronized. So, We are waiting until the FIFO finish and
diff --git a/Source/Core/Core/DolphinAnalytics.cpp b/Source/Core/Core/DolphinAnalytics.cpp
index 6ef1109cb4..93ed3888dd 100644
--- a/Source/Core/Core/DolphinAnalytics.cpp
+++ b/Source/Core/Core/DolphinAnalytics.cpp
@@ -360,7 +360,7 @@ void DolphinAnalytics::MakePerGameBuilder()
   builder.AddData("cfg-dsp-jit", Config::Get(Config::MAIN_DSP_JIT));
   builder.AddData("cfg-dsp-thread", Config::Get(Config::MAIN_DSP_THREAD));
   builder.AddData("cfg-cpu-thread", SConfig::GetInstance().bCPUThread);
-  builder.AddData("cfg-fastmem", SConfig::GetInstance().bFastmem);
+  builder.AddData("cfg-fastmem", Config::Get(Config::MAIN_FASTMEM));
   builder.AddData("cfg-syncgpu", SConfig::GetInstance().bSyncGPU);
   builder.AddData("cfg-audio-backend", Config::Get(Config::MAIN_AUDIO_BACKEND));
   builder.AddData("cfg-oc-enable", Config::Get(Config::MAIN_OVERCLOCK_ENABLE));
diff --git a/Source/Core/Core/HW/DVD/DVDInterface.cpp b/Source/Core/Core/HW/DVD/DVDInterface.cpp
index 0cbc27e205..338a3b009c 100644
--- a/Source/Core/Core/HW/DVD/DVDInterface.cpp
+++ b/Source/Core/Core/HW/DVD/DVDInterface.cpp
@@ -19,7 +19,6 @@
 #include "Common/Logging/Log.h"
 
 #include "Core/Config/MainSettings.h"
-#include "Core/ConfigManager.h"
 #include "Core/CoreTiming.h"
 #include "Core/DolphinAnalytics.h"
 #include "Core/HW/AudioInterface.h"
@@ -1382,7 +1381,7 @@ static void ScheduleReads(u64 offset, u32 length, const DiscIO::Partition& parti
   dvd_offset = Common::AlignDown(dvd_offset, DVD_ECC_BLOCK_SIZE);
   const u64 first_block = dvd_offset;
 
-  if (SConfig::GetInstance().bFastDiscSpeed)
+  if (Config::Get(Config::MAIN_FAST_DISC_SPEED))
   {
     // The SUDTR setting makes us act as if all reads are buffered
     buffer_start = std::numeric_limits<u64>::min();
diff --git a/Source/Core/Core/HW/SystemTimers.cpp b/Source/Core/Core/HW/SystemTimers.cpp
index 62f10cdef1..5f063a093e 100644
--- a/Source/Core/Core/HW/SystemTimers.cpp
+++ b/Source/Core/Core/HW/SystemTimers.cpp
@@ -173,8 +173,8 @@ void ThrottleCallback(u64 last_time, s64 cyclesLate)
   u64 time = Common::Timer::GetTimeUs();
 
   s64 diff = last_time - time;
-  const SConfig& config = SConfig::GetInstance();
-  bool frame_limiter = config.m_EmulationSpeed > 0.0f && !Core::GetIsThrottlerTempDisabled();
+  const float emulation_speed = Config::Get(Config::MAIN_EMULATION_SPEED);
+  bool frame_limiter = emulation_speed > 0.0f && !Core::GetIsThrottlerTempDisabled();
   u32 next_event = GetTicksPerSecond() / 1000;
 
   {
@@ -186,9 +186,9 @@ void ThrottleCallback(u64 last_time, s64 cyclesLate)
 
   if (frame_limiter)
   {
-    if (config.m_EmulationSpeed != 1.0f)
-      next_event = u32(next_event * config.m_EmulationSpeed);
-    const s64 max_fallback = config.iTimingVariance * 1000;
+    if (emulation_speed != 1.0f)
+      next_event = u32(next_event * emulation_speed);
+    const s64 max_fallback = Config::Get(Config::MAIN_TIMING_VARIANCE) * 1000;
     if (std::abs(diff) > max_fallback)
     {
       DEBUG_LOG_FMT(COMMON, "system too {}, {} ms skipped", diff < 0 ? "slow" : "fast",
diff --git a/Source/Core/Core/HW/WiimoteEmu/Speaker.cpp b/Source/Core/Core/HW/WiimoteEmu/Speaker.cpp
index 62aad0bc62..e09c991419 100644
--- a/Source/Core/Core/HW/WiimoteEmu/Speaker.cpp
+++ b/Source/Core/Core/HW/WiimoteEmu/Speaker.cpp
@@ -73,7 +73,7 @@ void stopdamnwav()
 void SpeakerLogic::SpeakerData(const u8* data, int length, float speaker_pan)
 {
   // TODO: should we still process samples for the decoder state?
-  if (!SConfig::GetInstance().m_WiimoteEnableSpeaker)
+  if (!m_speaker_enabled)
     return;
 
   if (reg_data.sample_rate == 0 || length == 0)
@@ -186,6 +186,11 @@ void SpeakerLogic::DoState(PointerWrap& p)
   p.Do(reg_data);
 }
 
+void SpeakerLogic::SetSpeakerEnabled(bool enabled)
+{
+  m_speaker_enabled = enabled;
+}
+
 int SpeakerLogic::BusRead(u8 slave_addr, u8 addr, int count, u8* data_out)
 {
   if (I2C_ADDR != slave_addr)
diff --git a/Source/Core/Core/HW/WiimoteEmu/Speaker.h b/Source/Core/Core/HW/WiimoteEmu/Speaker.h
index d2004df459..9a6a652bb1 100644
--- a/Source/Core/Core/HW/WiimoteEmu/Speaker.h
+++ b/Source/Core/Core/HW/WiimoteEmu/Speaker.h
@@ -29,6 +29,8 @@ public:
   void Reset();
   void DoState(PointerWrap& p);
 
+  void SetSpeakerEnabled(bool enabled);
+
 private:
   // Pan is -1.0 to +1.0
   void SpeakerData(const u8* data, int length, float speaker_pan);
@@ -71,6 +73,8 @@ private:
   ADPCMState adpcm_state{};
 
   ControllerEmu::SettingValue<double> m_speaker_pan_setting;
+
+  bool m_speaker_enabled = false;
 };
 
 }  // namespace WiimoteEmu
diff --git a/Source/Core/Core/HW/WiimoteEmu/WiimoteEmu.cpp b/Source/Core/Core/HW/WiimoteEmu/WiimoteEmu.cpp
index 4ccf02fc17..b266464021 100644
--- a/Source/Core/Core/HW/WiimoteEmu/WiimoteEmu.cpp
+++ b/Source/Core/Core/HW/WiimoteEmu/WiimoteEmu.cpp
@@ -17,8 +17,7 @@
 #include "Common/MathUtil.h"
 #include "Common/MsgHandler.h"
 
-#include "Core/Config/SYSCONFSettings.h"
-#include "Core/ConfigManager.h"
+#include "Core/Config/MainSettings.h"
 #include "Core/Core.h"
 #include "Core/HW/Wiimote.h"
 #include "Core/Movie.h"
@@ -297,6 +296,14 @@ Wiimote::Wiimote(const unsigned int index) : m_index(index)
   m_hotkeys->AddInput(_trans("Upright Hold"), false);
 
   Reset();
+
+  m_config_changed_callback_id = Config::AddConfigChangedCallback([this] { RefreshConfig(); });
+  RefreshConfig();
+}
+
+Wiimote::~Wiimote()
+{
+  Config::RemoveConfigChangedCallback(m_config_changed_callback_id);
 }
 
 std::string Wiimote::GetName() const
@@ -726,6 +733,11 @@ void Wiimote::SetRumble(bool on)
   m_rumble->controls.front()->control_ref->State(on);
 }
 
+void Wiimote::RefreshConfig()
+{
+  m_speaker_logic.SetSpeakerEnabled(Config::Get(Config::MAIN_WIIMOTE_ENABLE_SPEAKER));
+}
+
 void Wiimote::StepDynamics()
 {
   EmulateSwing(&m_swing_state, m_swing, 1.f / ::Wiimote::UPDATE_FREQ);
diff --git a/Source/Core/Core/HW/WiimoteEmu/WiimoteEmu.h b/Source/Core/Core/HW/WiimoteEmu/WiimoteEmu.h
index 8107111099..31448c6e3c 100644
--- a/Source/Core/Core/HW/WiimoteEmu/WiimoteEmu.h
+++ b/Source/Core/Core/HW/WiimoteEmu/WiimoteEmu.h
@@ -109,6 +109,7 @@ public:
   static constexpr u16 BUTTON_HOME = 0x8000;
 
   explicit Wiimote(unsigned int index);
+  ~Wiimote();
 
   std::string GetName() const override;
   void LoadDefaults(const ControllerInterface& ciface) override;
@@ -144,6 +145,8 @@ private:
   // This is the region exposed over bluetooth:
   static constexpr int EEPROM_FREE_SIZE = 0x1700;
 
+  void RefreshConfig();
+
   void StepDynamics();
   void UpdateButtonsStatus();
 
@@ -297,5 +300,7 @@ private:
   PositionalState m_shake_state;
 
   IMUCursorState m_imu_cursor_state;
+
+  size_t m_config_changed_callback_id;
 };
 }  // namespace WiimoteEmu
diff --git a/Source/Core/Core/HW/WiimoteReal/WiimoteReal.cpp b/Source/Core/Core/HW/WiimoteReal/WiimoteReal.cpp
index 06ae8e790a..1c57dff7ef 100644
--- a/Source/Core/Core/HW/WiimoteReal/WiimoteReal.cpp
+++ b/Source/Core/Core/HW/WiimoteReal/WiimoteReal.cpp
@@ -111,7 +111,7 @@ void ProcessWiimotePool()
   for (u32 index = 0; index != MAX_WIIMOTES; ++index)
     TryToFillWiimoteSlot(index);
 
-  if (SConfig::GetInstance().connect_wiimotes_for_ciface)
+  if (Config::Get(Config::MAIN_CONNECT_WIIMOTES_FOR_CONTROLLER_INTERFACE))
   {
     for (auto& entry : s_wiimote_pool)
       ciface::WiimoteController::AddDevice(std::move(entry.wiimote));
@@ -142,7 +142,16 @@ void AddWiimoteToPool(std::unique_ptr<Wiimote> wiimote)
   s_wiimote_pool.emplace_back(WiimotePoolEntry{std::move(wiimote)});
 }
 
-Wiimote::Wiimote() = default;
+Wiimote::Wiimote()
+{
+  m_config_changed_callback_id = Config::AddConfigChangedCallback([this] { RefreshConfig(); });
+  RefreshConfig();
+}
+
+Wiimote::~Wiimote()
+{
+  Config::RemoveConfigChangedCallback(m_config_changed_callback_id);
+}
 
 void Wiimote::Shutdown()
 {
@@ -263,7 +272,7 @@ void Wiimote::InterruptDataOutput(const u8* data, const u32 size)
     }
   }
   else if (rpt[1] == u8(OutputReportID::SpeakerData) &&
-           (!SConfig::GetInstance().m_WiimoteEnableSpeaker || !m_speaker_enable || m_speaker_mute))
+           (!m_speaker_enabled_in_dolphin_config || !m_speaker_enable || m_speaker_mute))
   {
     rpt.resize(3);
     // Translate undesired speaker data reports into rumble reports.
@@ -677,7 +686,7 @@ void WiimoteScanner::ThreadFunc()
       continue;
 
     // If we don't want Wiimotes in ControllerInterface, we may not need them at all.
-    if (!SConfig::GetInstance().connect_wiimotes_for_ciface)
+    if (!Config::Get(Config::MAIN_CONNECT_WIIMOTES_FOR_CONTROLLER_INTERFACE))
     {
       // We don't want any remotes in passthrough mode or running in GC mode.
       const bool core_running = Core::GetState() != Core::State::Uninitialized;
@@ -804,6 +813,11 @@ void Wiimote::ThreadFunc()
   DisconnectInternal();
 }
 
+void Wiimote::RefreshConfig()
+{
+  m_speaker_enabled_in_dolphin_config = Config::Get(Config::MAIN_WIIMOTE_ENABLE_SPEAKER);
+}
+
 int Wiimote::GetIndex() const
 {
   return m_index;
@@ -843,7 +857,7 @@ void Initialize(::Wiimote::InitializeMode init_mode)
     s_wiimote_scanner.StartThread();
   }
 
-  if (SConfig::GetInstance().m_WiimoteContinuousScanning)
+  if (Config::Get(Config::MAIN_WIIMOTE_CONTINUOUS_SCANNING))
     s_wiimote_scanner.SetScanMode(WiimoteScanMode::CONTINUOUSLY_SCAN);
   else
     s_wiimote_scanner.SetScanMode(WiimoteScanMode::DO_NOT_SCAN);
@@ -957,7 +971,7 @@ static void HandleWiimoteDisconnect(int index)
 // This is called from the GUI thread
 void Refresh()
 {
-  if (!SConfig::GetInstance().m_WiimoteContinuousScanning)
+  if (!Config::Get(Config::MAIN_WIIMOTE_CONTINUOUS_SCANNING))
     s_wiimote_scanner.SetScanMode(WiimoteScanMode::SCAN_ONCE);
 }
 
diff --git a/Source/Core/Core/HW/WiimoteReal/WiimoteReal.h b/Source/Core/Core/HW/WiimoteReal/WiimoteReal.h
index 18b927962c..34573a0609 100644
--- a/Source/Core/Core/HW/WiimoteReal/WiimoteReal.h
+++ b/Source/Core/Core/HW/WiimoteReal/WiimoteReal.h
@@ -51,7 +51,7 @@ public:
   Wiimote(Wiimote&&) = delete;
   Wiimote& operator=(Wiimote&&) = delete;
 
-  virtual ~Wiimote() {}
+  ~Wiimote() override;
   // This needs to be called in derived destructors!
   void Shutdown();
 
@@ -125,6 +125,8 @@ private:
 
   void ThreadFunc();
 
+  void RefreshConfig();
+
   bool m_is_linked = false;
 
   // We track the speaker state to convert unnecessary speaker data into rumble reports.
@@ -144,6 +146,10 @@ private:
 
   Common::SPSCQueue<Report> m_read_reports;
   Common::SPSCQueue<Report> m_write_reports;
+
+  bool m_speaker_enabled_in_dolphin_config = false;
+
+  size_t m_config_changed_callback_id;
 };
 
 class WiimoteScannerBackend
@@ -209,5 +215,4 @@ void InitAdapterClass();
 void HandleWiimotesInControllerInterfaceSettingChange();
 void PopulateDevices();
 void ProcessWiimotePool();
-
 }  // namespace WiimoteReal
diff --git a/Source/Core/Core/IOS/DolphinDevice.cpp b/Source/Core/Core/IOS/DolphinDevice.cpp
index 699cacfd42..3c533f9ab0 100644
--- a/Source/Core/Core/IOS/DolphinDevice.cpp
+++ b/Source/Core/Core/IOS/DolphinDevice.cpp
@@ -14,9 +14,7 @@
 #include "Common/SettingsHandler.h"
 #include "Common/Timer.h"
 #include "Common/Version.h"
-#include "Core/BootManager.h"
 #include "Core/Config/MainSettings.h"
-#include "Core/ConfigManager.h"
 #include "Core/Core.h"
 #include "Core/HW/Memmap.h"
 
@@ -103,8 +101,7 @@ IPCReply GetSpeedLimit(const IOCtlVRequest& request)
     return IPCReply(IPC_EINVAL);
   }
 
-  const SConfig& config = SConfig::GetInstance();
-  const u32 speed_percent = config.m_EmulationSpeed * 100;
+  const u32 speed_percent = Config::Get(Config::MAIN_EMULATION_SPEED) * 100;
   Memory::Write_U32(speed_percent, request.io_vectors[0].address);
 
   return IPCReply(IPC_SUCCESS);
@@ -124,8 +121,7 @@ IPCReply SetSpeedLimit(const IOCtlVRequest& request)
   }
 
   const float speed = float(Memory::Read_U32(request.in_vectors[0].address)) / 100.0f;
-  SConfig::GetInstance().m_EmulationSpeed = speed;
-  BootManager::SetEmulationSpeedReset(true);
+  Config::SetCurrent(Config::MAIN_EMULATION_SPEED, speed);
 
   return IPCReply(IPC_SUCCESS);
 }
diff --git a/Source/Core/Core/IOS/SDIO/SDIOSlot0.cpp b/Source/Core/Core/IOS/SDIO/SDIOSlot0.cpp
index 3355996ff9..c6dcab44e5 100644
--- a/Source/Core/Core/IOS/SDIO/SDIOSlot0.cpp
+++ b/Source/Core/Core/IOS/SDIO/SDIOSlot0.cpp
@@ -16,7 +16,6 @@
 #include "Common/SDCardUtil.h"
 #include "Core/Config/MainSettings.h"
 #include "Core/Config/SessionSettings.h"
-#include "Core/ConfigManager.h"
 #include "Core/HW/Memmap.h"
 #include "Core/IOS/IOS.h"
 #include "Core/IOS/VersionInfo.h"
@@ -49,10 +48,10 @@ void SDIOSlot0Device::EventNotify()
 {
   if (!m_event)
     return;
-  // Accessing SConfig variables like this isn't really threadsafe,
-  // but this is how it's done all over the place...
-  if ((SConfig::GetInstance().m_WiiSDCard && m_event->type == EVENT_INSERT) ||
-      (!SConfig::GetInstance().m_WiiSDCard && m_event->type == EVENT_REMOVE))
+
+  const bool sd_card_inserted = Config::Get(Config::MAIN_WII_SD_CARD);
+  if ((sd_card_inserted && m_event->type == EVENT_INSERT) ||
+      (!sd_card_inserted && m_event->type == EVENT_REMOVE))
   {
     m_ios.EnqueueIPCReply(m_event->request, m_event->type);
     m_event.reset();
@@ -440,8 +439,8 @@ IPCReply SDIOSlot0Device::GetStatus(const IOCtlRequest& request)
 
   // Evaluate whether a card is currently inserted (config value).
   // Make sure we don't modify m_status so we don't lose track of whether the card is SDHC.
-  const u32 status =
-      SConfig::GetInstance().m_WiiSDCard ? (m_status | CARD_INSERTED) : CARD_NOT_EXIST;
+  const bool sd_card_inserted = Config::Get(Config::MAIN_WII_SD_CARD);
+  const u32 status = sd_card_inserted ? (m_status | CARD_INSERTED) : CARD_NOT_EXIST;
 
   INFO_LOG_FMT(IOS_SD, "IOCTL_GETSTATUS. Replying that {} card is {}{}",
                (status & CARD_SDHC) ? "SDHC" : "SD",
diff --git a/Source/Core/Core/IOS/USB/USB_KBD.cpp b/Source/Core/Core/IOS/USB/USB_KBD.cpp
index c6cd20a24a..5f18f50dfb 100644
--- a/Source/Core/Core/IOS/USB/USB_KBD.cpp
+++ b/Source/Core/Core/IOS/USB/USB_KBD.cpp
@@ -10,7 +10,7 @@
 #include "Common/IniFile.h"
 #include "Common/Logging/Log.h"
 #include "Common/Swap.h"
-#include "Core/ConfigManager.h"
+#include "Core/Config/MainSettings.h"
 #include "Core/Core.h"  // Local core functions
 #include "Core/HW/Memmap.h"
 #include "InputCommon/ControlReference/ControlReference.h"  // For background input check
@@ -210,7 +210,7 @@ std::optional<IPCReply> USB_KBD::Write(const ReadWriteRequest& request)
 
 std::optional<IPCReply> USB_KBD::IOCtl(const IOCtlRequest& request)
 {
-  if (SConfig::GetInstance().m_WiiKeyboard && !Core::WantsDeterminism() &&
+  if (Config::Get(Config::MAIN_WII_KEYBOARD) && !Core::WantsDeterminism() &&
       ControlReference::GetInputGate() && !m_message_queue.empty())
   {
     Memory::CopyToEmu(request.buffer_out, &m_message_queue.front(), sizeof(MessageData));
@@ -231,7 +231,7 @@ bool USB_KBD::IsKeyPressed(int key) const
 
 void USB_KBD::Update()
 {
-  if (!SConfig::GetInstance().m_WiiKeyboard || Core::WantsDeterminism() || !m_is_active)
+  if (!Config::Get(Config::MAIN_WII_KEYBOARD) || Core::WantsDeterminism() || !m_is_active)
     return;
 
   u8 modifiers = 0x00;
diff --git a/Source/Core/Core/NetPlayClient.cpp b/Source/Core/Core/NetPlayClient.cpp
index 6dad22e5ba..4e40ec7f3b 100644
--- a/Source/Core/Core/NetPlayClient.cpp
+++ b/Source/Core/Core/NetPlayClient.cpp
@@ -2033,13 +2033,13 @@ bool NetPlayClient::GetNetPads(const int pad_nb, const bool batching, GCPadStatu
       if (time_diff.count() >= 1.0 || !buffer_over_target)
       {
         // run fast if the buffer is overfilled, otherwise run normal speed
-        SConfig::GetInstance().m_EmulationSpeed = buffer_over_target ? 0.0f : 1.0f;
+        Config::SetCurrent(Config::MAIN_EMULATION_SPEED, buffer_over_target ? 0.0f : 1.0f);
       }
     }
     else
     {
       // Set normal speed when we're the host, otherwise it can get stuck at unlimited
-      SConfig::GetInstance().m_EmulationSpeed = 1.0f;
+      Config::SetCurrent(Config::MAIN_EMULATION_SPEED, 1.0f);
     }
   }
 
diff --git a/Source/Core/Core/PowerPC/Jit64/Jit.cpp b/Source/Core/Core/PowerPC/Jit64/Jit.cpp
index 84e2970d27..fc77921ece 100644
--- a/Source/Core/Core/PowerPC/Jit64/Jit.cpp
+++ b/Source/Core/Core/PowerPC/Jit64/Jit.cpp
@@ -332,7 +332,7 @@ void Jit64::Init()
 {
   EnableBlockLink();
 
-  jo.fastmem_arena = SConfig::GetInstance().bFastmem && Memory::InitFastmemArena();
+  jo.fastmem_arena = m_fastmem_enabled && Memory::InitFastmemArena();
   jo.optimizeGatherPipe = true;
   jo.accurateSinglePrecision = true;
   UpdateMemoryAndExceptionOptions();
@@ -355,8 +355,7 @@ void Jit64::Init()
 
   // BLR optimization has the same consequences as block linking, as well as
   // depending on the fault handler to be safe in the event of excessive BL.
-  m_enable_blr_optimization =
-      jo.enableBlocklink && SConfig::GetInstance().bFastmem && !m_enable_debugging;
+  m_enable_blr_optimization = jo.enableBlocklink && m_fastmem_enabled && !m_enable_debugging;
   m_cleanup_after_stackfault = false;
 
   m_stack = nullptr;
diff --git a/Source/Core/Core/PowerPC/JitArm64/Jit.cpp b/Source/Core/Core/PowerPC/JitArm64/Jit.cpp
index da44109464..c701f160c6 100644
--- a/Source/Core/Core/PowerPC/JitArm64/Jit.cpp
+++ b/Source/Core/Core/PowerPC/JitArm64/Jit.cpp
@@ -52,7 +52,7 @@ void JitArm64::Init()
   AllocCodeSpace(CODE_SIZE + child_code_size);
   AddChildCodeSpace(&m_far_code, child_code_size);
 
-  jo.fastmem_arena = SConfig::GetInstance().bFastmem && Memory::InitFastmemArena();
+  jo.fastmem_arena = m_fastmem_enabled && Memory::InitFastmemArena();
   jo.enableBlocklink = true;
   jo.optimizeGatherPipe = true;
   UpdateMemoryAndExceptionOptions();
@@ -67,8 +67,7 @@ void JitArm64::Init()
   analyzer.SetOption(PPCAnalyst::PPCAnalyzer::OPTION_CARRY_MERGE);
   analyzer.SetOption(PPCAnalyst::PPCAnalyzer::OPTION_BRANCH_FOLLOW);
 
-  m_enable_blr_optimization =
-      jo.enableBlocklink && SConfig::GetInstance().bFastmem && !m_enable_debugging;
+  m_enable_blr_optimization = jo.enableBlocklink && m_fastmem_enabled && !m_enable_debugging;
   m_cleanup_after_stackfault = false;
 
   AllocStack();
diff --git a/Source/Core/Core/PowerPC/JitCommon/JitBase.cpp b/Source/Core/Core/PowerPC/JitCommon/JitBase.cpp
index 53d41868a5..5dfe40cfd4 100644
--- a/Source/Core/Core/PowerPC/JitCommon/JitBase.cpp
+++ b/Source/Core/Core/PowerPC/JitCommon/JitBase.cpp
@@ -54,6 +54,7 @@ void JitBase::RefreshConfig()
   m_low_dcbz_hack = Config::Get(Config::MAIN_LOW_DCBZ_HACK);
   m_fprf = Config::Get(Config::MAIN_FPRF);
   m_accurate_nans = Config::Get(Config::MAIN_ACCURATE_NANS);
+  m_fastmem_enabled = Config::Get(Config::MAIN_FASTMEM);
   analyzer.SetDebuggingEnabled(m_enable_debugging);
   analyzer.SetBranchFollowingEnabled(Config::Get(Config::MAIN_JIT_FOLLOW_BRANCH));
   analyzer.SetFloatExceptionsEnabled(m_enable_float_exceptions);
@@ -78,7 +79,7 @@ bool JitBase::CanMergeNextInstructions(int count) const
 void JitBase::UpdateMemoryAndExceptionOptions()
 {
   bool any_watchpoints = PowerPC::memchecks.HasAny();
-  jo.fastmem = SConfig::GetInstance().bFastmem && jo.fastmem_arena && (MSR.DR || !any_watchpoints);
+  jo.fastmem = m_fastmem_enabled && jo.fastmem_arena && (MSR.DR || !any_watchpoints);
   jo.memcheck = SConfig::GetInstance().bMMU || any_watchpoints;
   jo.fp_exceptions = m_enable_float_exceptions;
   jo.div_by_zero_exceptions = m_enable_div_by_zero_exceptions;
diff --git a/Source/Core/Core/PowerPC/JitCommon/JitBase.h b/Source/Core/Core/PowerPC/JitCommon/JitBase.h
index ccda3fc12d..d9e7ae8e94 100644
--- a/Source/Core/Core/PowerPC/JitCommon/JitBase.h
+++ b/Source/Core/Core/PowerPC/JitCommon/JitBase.h
@@ -132,6 +132,7 @@ protected:
   bool m_low_dcbz_hack = false;
   bool m_fprf = false;
   bool m_accurate_nans = false;
+  bool m_fastmem_enabled = false;
 
   void RefreshConfig();
 
diff --git a/Source/Core/Core/PowerPC/JitCommon/JitCache.cpp b/Source/Core/Core/PowerPC/JitCommon/JitCache.cpp
index b25e3fba90..de55900846 100644
--- a/Source/Core/Core/PowerPC/JitCommon/JitCache.cpp
+++ b/Source/Core/Core/PowerPC/JitCommon/JitCache.cpp
@@ -13,7 +13,7 @@
 
 #include "Common/CommonTypes.h"
 #include "Common/JitRegister.h"
-#include "Core/ConfigManager.h"
+#include "Core/Config/MainSettings.h"
 #include "Core/Core.h"
 #include "Core/PowerPC/JitCommon/JitBase.h"
 #include "Core/PowerPC/MMU.h"
@@ -40,7 +40,7 @@ JitBaseBlockCache::~JitBaseBlockCache() = default;
 
 void JitBaseBlockCache::Init()
 {
-  JitRegister::Init(SConfig::GetInstance().m_perfDir);
+  JitRegister::Init(Config::Get(Config::MAIN_PERF_MAP_DIR));
 
   Clear();
 }
diff --git a/Source/Core/Core/PowerPC/PPCCache.cpp b/Source/Core/Core/PowerPC/PPCCache.cpp
index 181764dc3b..9207ea5f72 100644
--- a/Source/Core/Core/PowerPC/PPCCache.cpp
+++ b/Source/Core/Core/PowerPC/PPCCache.cpp
@@ -7,7 +7,7 @@
 
 #include "Common/ChunkFile.h"
 #include "Common/Swap.h"
-#include "Core/ConfigManager.h"
+#include "Core/Config/MainSettings.h"
 #include "Core/DolphinAnalytics.h"
 #include "Core/HW/Memmap.h"
 #include "Core/PowerPC/JitInterface.h"
@@ -87,6 +87,12 @@ constexpr std::array<u32, 128> s_way_from_plru = [] {
 }();
 }  // Anonymous namespace
 
+InstructionCache::~InstructionCache()
+{
+  if (m_config_callback_id)
+    Config::RemoveConfigChangedCallback(*m_config_callback_id);
+}
+
 void InstructionCache::Reset()
 {
   valid.fill(0);
@@ -99,6 +105,10 @@ void InstructionCache::Reset()
 
 void InstructionCache::Init()
 {
+  if (!m_config_callback_id)
+    m_config_callback_id = Config::AddConfigChangedCallback([this] { RefreshConfig(); });
+  RefreshConfig();
+
   data.fill({});
   tags.fill({});
   Reset();
@@ -106,7 +116,7 @@ void InstructionCache::Init()
 
 void InstructionCache::Invalidate(u32 addr)
 {
-  if (!HID0.ICE || SConfig::GetInstance().bDisableICache)
+  if (!HID0.ICE || m_disable_icache)
     return;
 
   // Invalidates the whole set
@@ -129,7 +139,7 @@ void InstructionCache::Invalidate(u32 addr)
 
 u32 InstructionCache::ReadInstruction(u32 addr)
 {
-  if (!HID0.ICE || SConfig::GetInstance().bDisableICache)  // instruction cache is disabled
+  if (!HID0.ICE || m_disable_icache)  // instruction cache is disabled
     return Memory::Read_U32(addr);
   u32 set = (addr >> 5) & 0x7f;
   u32 tag = addr >> 12;
@@ -202,4 +212,9 @@ void InstructionCache::DoState(PointerWrap& p)
   p.DoArray(lookup_table_ex);
   p.DoArray(lookup_table_vmem);
 }
+
+void InstructionCache::RefreshConfig()
+{
+  m_disable_icache = Config::Get(Config::MAIN_DISABLE_ICACHE);
+}
 }  // namespace PowerPC
diff --git a/Source/Core/Core/PowerPC/PPCCache.h b/Source/Core/Core/PowerPC/PPCCache.h
index fdc23ba546..431bc10c41 100644
--- a/Source/Core/Core/PowerPC/PPCCache.h
+++ b/Source/Core/Core/PowerPC/PPCCache.h
@@ -4,6 +4,7 @@
 #pragma once
 
 #include <array>
+#include <optional>
 
 #include "Common/CommonTypes.h"
 
@@ -30,11 +31,16 @@ struct InstructionCache
   std::array<u8, 1 << 21> lookup_table_ex{};
   std::array<u8, 1 << 20> lookup_table_vmem{};
 
+  bool m_disable_icache = false;
+  std::optional<size_t> m_config_callback_id = std::nullopt;
+
   InstructionCache() = default;
+  ~InstructionCache();
   u32 ReadInstruction(u32 addr);
   void Invalidate(u32 addr);
   void Init();
   void Reset();
   void DoState(PointerWrap& p);
+  void RefreshConfig();
 };
 }  // namespace PowerPC
diff --git a/Source/Core/DolphinQt/Config/WiimoteControllersWidget.cpp b/Source/Core/DolphinQt/Config/WiimoteControllersWidget.cpp
index 70a65f5752..e5616da4bf 100644
--- a/Source/Core/DolphinQt/Config/WiimoteControllersWidget.cpp
+++ b/Source/Core/DolphinQt/Config/WiimoteControllersWidget.cpp
@@ -305,9 +305,9 @@ void WiimoteControllersWidget::LoadSettings()
   }
   m_wiimote_real_balance_board->setChecked(WiimoteCommon::GetSource(WIIMOTE_BALANCE_BOARD) ==
                                            WiimoteSource::Real);
-  m_wiimote_speaker_data->setChecked(SConfig::GetInstance().m_WiimoteEnableSpeaker);
-  m_wiimote_ciface->setChecked(SConfig::GetInstance().connect_wiimotes_for_ciface);
-  m_wiimote_continuous_scanning->setChecked(SConfig::GetInstance().m_WiimoteContinuousScanning);
+  m_wiimote_speaker_data->setChecked(Config::Get(Config::MAIN_WIIMOTE_ENABLE_SPEAKER));
+  m_wiimote_ciface->setChecked(Config::Get(Config::MAIN_CONNECT_WIIMOTES_FOR_CONTROLLER_INTERFACE));
+  m_wiimote_continuous_scanning->setChecked(Config::Get(Config::MAIN_WIIMOTE_CONTINUOUS_SCANNING));
 
   if (Config::Get(Config::MAIN_BLUETOOTH_PASSTHROUGH_ENABLED))
     m_wiimote_passthrough->setChecked(true);
@@ -319,9 +319,12 @@ void WiimoteControllersWidget::LoadSettings()
 
 void WiimoteControllersWidget::SaveSettings()
 {
-  SConfig::GetInstance().m_WiimoteEnableSpeaker = m_wiimote_speaker_data->isChecked();
-  SConfig::GetInstance().connect_wiimotes_for_ciface = m_wiimote_ciface->isChecked();
-  SConfig::GetInstance().m_WiimoteContinuousScanning = m_wiimote_continuous_scanning->isChecked();
+  Config::SetBaseOrCurrent(Config::MAIN_WIIMOTE_ENABLE_SPEAKER,
+                           m_wiimote_speaker_data->isChecked());
+  Config::SetBaseOrCurrent(Config::MAIN_CONNECT_WIIMOTES_FOR_CONTROLLER_INTERFACE,
+                           m_wiimote_ciface->isChecked());
+  Config::SetBaseOrCurrent(Config::MAIN_WIIMOTE_CONTINUOUS_SCANNING,
+                           m_wiimote_continuous_scanning->isChecked());
   Config::SetBaseOrCurrent(Config::MAIN_BLUETOOTH_PASSTHROUGH_ENABLED,
                            m_wiimote_passthrough->isChecked());
 
diff --git a/Source/Core/DolphinQt/HotkeyScheduler.cpp b/Source/Core/DolphinQt/HotkeyScheduler.cpp
index 4fa3031e63..c3d2aadcb7 100644
--- a/Source/Core/DolphinQt/HotkeyScheduler.cpp
+++ b/Source/Core/DolphinQt/HotkeyScheduler.cpp
@@ -459,26 +459,26 @@ void HotkeyScheduler::Run()
       Core::SetIsThrottlerTempDisabled(IsHotkey(HK_TOGGLE_THROTTLE, true));
 
       auto ShowEmulationSpeed = []() {
+        const float emulation_speed = Config::Get(Config::MAIN_EMULATION_SPEED);
         OSD::AddMessage(
-            SConfig::GetInstance().m_EmulationSpeed <= 0 ?
+            emulation_speed <= 0 ?
                 "Speed Limit: Unlimited" :
-                StringFromFormat("Speed Limit: %li%%",
-                                 std::lround(SConfig::GetInstance().m_EmulationSpeed * 100.f)));
+                StringFromFormat("Speed Limit: %li%%", std::lround(emulation_speed * 100.f)));
       };
 
       if (IsHotkey(HK_DECREASE_EMULATION_SPEED))
       {
-        auto speed = SConfig::GetInstance().m_EmulationSpeed - 0.1;
+        auto speed = Config::Get(Config::MAIN_EMULATION_SPEED) - 0.1;
         speed = (speed <= 0 || (speed >= 0.95 && speed <= 1.05)) ? 1.0 : speed;
-        SConfig::GetInstance().m_EmulationSpeed = speed;
+        Config::SetCurrent(Config::MAIN_EMULATION_SPEED, speed);
         ShowEmulationSpeed();
       }
 
       if (IsHotkey(HK_INCREASE_EMULATION_SPEED))
       {
-        auto speed = SConfig::GetInstance().m_EmulationSpeed + 0.1;
+        auto speed = Config::Get(Config::MAIN_EMULATION_SPEED) + 0.1;
         speed = (speed >= 0.95 && speed <= 1.05) ? 1.0 : speed;
-        SConfig::GetInstance().m_EmulationSpeed = speed;
+        Config::SetCurrent(Config::MAIN_EMULATION_SPEED, speed);
         ShowEmulationSpeed();
       }
 
diff --git a/Source/Core/DolphinQt/MenuBar.cpp b/Source/Core/DolphinQt/MenuBar.cpp
index c2d64f52f0..0c08dd3390 100644
--- a/Source/Core/DolphinQt/MenuBar.cpp
+++ b/Source/Core/DolphinQt/MenuBar.cpp
@@ -829,9 +829,9 @@ void MenuBar::AddJITMenu()
 
   m_jit_disable_fastmem = m_jit->addAction(tr("Disable Fastmem"));
   m_jit_disable_fastmem->setCheckable(true);
-  m_jit_disable_fastmem->setChecked(!SConfig::GetInstance().bFastmem);
+  m_jit_disable_fastmem->setChecked(!Config::Get(Config::MAIN_FASTMEM));
   connect(m_jit_disable_fastmem, &QAction::toggled, [this](bool enabled) {
-    SConfig::GetInstance().bFastmem = !enabled;
+    Config::SetBaseOrCurrent(Config::MAIN_FASTMEM, !enabled);
     ClearCache();
   });
 
diff --git a/Source/Core/DolphinQt/Settings.cpp b/Source/Core/DolphinQt/Settings.cpp
index 44bcd581b1..d22dcc6e25 100644
--- a/Source/Core/DolphinQt/Settings.cpp
+++ b/Source/Core/DolphinQt/Settings.cpp
@@ -696,14 +696,14 @@ void Settings::SetBatchModeEnabled(bool batch)
 
 bool Settings::IsSDCardInserted() const
 {
-  return SConfig::GetInstance().m_WiiSDCard;
+  return Config::Get(Config::MAIN_WII_SD_CARD);
 }
 
 void Settings::SetSDCardInserted(bool inserted)
 {
   if (IsSDCardInserted() != inserted)
   {
-    SConfig::GetInstance().m_WiiSDCard = inserted;
+    Config::SetBaseOrCurrent(Config::MAIN_WII_SD_CARD, inserted);
     emit SDCardInsertionChanged(inserted);
 
     auto* ios = IOS::HLE::GetIOS();
@@ -714,14 +714,14 @@ void Settings::SetSDCardInserted(bool inserted)
 
 bool Settings::IsUSBKeyboardConnected() const
 {
-  return SConfig::GetInstance().m_WiiKeyboard;
+  return Config::Get(Config::MAIN_WII_KEYBOARD);
 }
 
 void Settings::SetUSBKeyboardConnected(bool connected)
 {
   if (IsUSBKeyboardConnected() != connected)
   {
-    SConfig::GetInstance().m_WiiKeyboard = connected;
+    Config::SetBaseOrCurrent(Config::MAIN_WII_KEYBOARD, connected);
     emit USBKeyboardConnectionChanged(connected);
   }
 }
diff --git a/Source/Core/DolphinQt/Settings/GeneralPane.cpp b/Source/Core/DolphinQt/Settings/GeneralPane.cpp
index d25efbf0ae..05ea785484 100644
--- a/Source/Core/DolphinQt/Settings/GeneralPane.cpp
+++ b/Source/Core/DolphinQt/Settings/GeneralPane.cpp
@@ -260,7 +260,7 @@ void GeneralPane::LoadConfig()
 #ifdef USE_DISCORD_PRESENCE
   m_checkbox_discord_presence->setChecked(Config::Get(Config::MAIN_USE_DISCORD_PRESENCE));
 #endif
-  int selection = qRound(SConfig::GetInstance().m_EmulationSpeed * 10);
+  int selection = qRound(Config::Get(Config::MAIN_EMULATION_SPEED) * 10);
   if (selection < m_combobox_speedlimit->count())
     m_combobox_speedlimit->setCurrentIndex(selection);
   m_checkbox_dualcore->setChecked(SConfig::GetInstance().bCPUThread);
@@ -353,7 +353,8 @@ void GeneralPane::OnSaveConfig()
                            m_checkbox_override_region_settings->isChecked());
   Config::SetBase(Config::MAIN_AUTO_DISC_CHANGE, m_checkbox_auto_disc_change->isChecked());
   Config::SetBaseOrCurrent(Config::MAIN_ENABLE_CHEATS, m_checkbox_cheats->isChecked());
-  settings.m_EmulationSpeed = m_combobox_speedlimit->currentIndex() * 0.1f;
+  Config::SetBaseOrCurrent(Config::MAIN_EMULATION_SPEED,
+                           m_combobox_speedlimit->currentIndex() * 0.1f);
   Settings::Instance().SetFallbackRegion(
       UpdateFallbackRegionFromIndex(m_combobox_fallback_region->currentIndex()));
 
diff --git a/Source/Core/VideoCommon/Fifo.cpp b/Source/Core/VideoCommon/Fifo.cpp
index f96c71b550..33dd94817d 100644
--- a/Source/Core/VideoCommon/Fifo.cpp
+++ b/Source/Core/VideoCommon/Fifo.cpp
@@ -14,6 +14,7 @@
 #include "Common/MemoryUtil.h"
 #include "Common/MsgHandler.h"
 
+#include "Core/Config/MainSettings.h"
 #include "Core/ConfigManager.h"
 #include "Core/CoreTiming.h"
 #include "Core/HW/Memmap.h"
@@ -509,15 +510,15 @@ void UpdateWantDeterminism(bool want)
   // it should be safe to change this.
   const SConfig& param = SConfig::GetInstance();
   bool gpu_thread = false;
-  switch (param.m_GPUDeterminismMode)
+  switch (Config::GetGPUDeterminismMode())
   {
-  case GPUDeterminismMode::Auto:
+  case Config::GPUDeterminismMode::Auto:
     gpu_thread = want;
     break;
-  case GPUDeterminismMode::Disabled:
+  case Config::GPUDeterminismMode::Disabled:
     gpu_thread = false;
     break;
-  case GPUDeterminismMode::FakeCompletion:
+  case Config::GPUDeterminismMode::FakeCompletion:
     gpu_thread = true;
     break;
   }
diff --git a/Source/Core/VideoCommon/VideoConfig.cpp b/Source/Core/VideoCommon/VideoConfig.cpp
index a835625691..c8f79b0e66 100644
--- a/Source/Core/VideoCommon/VideoConfig.cpp
+++ b/Source/Core/VideoCommon/VideoConfig.cpp
@@ -9,7 +9,7 @@
 #include "Common/CommonTypes.h"
 #include "Common/StringUtil.h"
 #include "Core/Config/GraphicsSettings.h"
-#include "Core/ConfigManager.h"
+#include "Core/Config/MainSettings.h"
 #include "Core/Core.h"
 #include "Core/Movie.h"
 #include "VideoCommon/DriverDetails.h"
@@ -24,7 +24,7 @@ static bool IsVSyncActive(bool enabled)
 {
   // Vsync is disabled when the throttler is disabled by the tab key.
   return enabled && !Core::GetIsThrottlerTempDisabled() &&
-         SConfig::GetInstance().m_EmulationSpeed == 1.0;
+         Config::Get(Config::MAIN_EMULATION_SPEED) == 1.0;
 }
 
 void UpdateActiveConfig()