diff --git a/Makefile b/Makefile
index 046e11a9..ed7d3cb4 100755
--- a/Makefile
+++ b/Makefile
@@ -34,6 +34,12 @@ else
 MKDIR := mkdir
 endif
 
+ifeq ($(CONF),native_release)
+override CONF := release
+LDFLAGS += -march=native -mtune=native
+CFLAGS += -march=native -mtune=native
+endif
+
 # Set compilation and linkage flags based on target, platform and configuration
 
 CFLAGS += -Werror -Wall -std=gnu11 -ICore -D_GNU_SOURCE -DVERSION="$(VERSION)" -I. -D_USE_MATH_DEFINES
@@ -70,7 +76,7 @@ LDFLAGS += -flto
 CFLAGS += -flto
 endif
 else
-$(error Invalid value for CONF: $(CONF). Use "debug" or "release")
+$(error Invalid value for CONF: $(CONF). Use "debug", "release" or "native_release")
 endif
 
 # Define our targets
diff --git a/README.md b/README.md
index 88ff2434..0eb4599c 100644
--- a/README.md
+++ b/README.md
@@ -46,6 +46,6 @@ On Windows, SameBoy also requires:
  * [GnuWin](http://gnuwin32.sourceforge.net/)
  * Running vcvars32 before running make. Make sure all required tools and libraries are in %PATH% and %lib%, repsectively.
 
-To compile, simply run `make`. The targets are cocoa (Default for OS X), sdl (Default for everything else), bootroms and tester. You may also specify CONF=debug (default) or CONF=release to control optimization and symbols, and specify BOOTROMS_DIR=... to a directory containing precompiled dmg_boot.bin and cgb_boot.bin files, otherwise the build system will compile and use SameBoy's own boot ROMs.
+To compile, simply run `make`. The targets are cocoa (Default for OS X), sdl (Default for everything else), bootroms and tester. You may also specify CONF=debug (default), CONF=release or CONF=native_release to control optimization and symbols. native_release is faster than release, but is optimized to the host's CPU and therefore is not portable. You may set BOOTROMS_DIR=... to a directory containing precompiled dmg_boot.bin and cgb_boot.bin files, otherwise the build system will compile and use SameBoy's own boot ROMs.
 
-SameBoy was compiled and tested on OS X, Ubuntu and Windows 7 32-bit.
+SameBoy was compiled and tested on macOS, Ubuntu and 32-bit Windows 7.